Determination of Uncombined Intermediates in FD&C Yellow No. 6 by High-Pressure Liquid Chromatography
Keyword(s):
Abstract A high-pressure liquid chromatographic method is presented for the isolation and determination of uncombined intermediates in FD&C Yellow No. 6 (sunset yellow FCF, CI. No. 15895). Samples of FD&C Yellow No. 6 containing 0.1-0.4% sulfanilic acid, 0.1-0.4% 6-hydroxy-2-naphthalenesulfonic acid, and 0.3— 1.0% 6,6'-oxybis(2-naphthalenesulfonic acid) were prepared and analyzed using this method. Recoveries ranged between 94 and 101%. Twenty-two samples of FD&C Yellow No. 6 were analyzed by the conventional column elution chromatographic method as well as by the high-pressure liquid chromatographic method. Good agreement was obtained between the 2 methods.
1975 ◽
Vol 58
(4)
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pp. 754-756
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1978 ◽
Vol 39
(02)
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pp. 466-473
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1981 ◽
Vol 5
(1)
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pp. 24-28
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1975 ◽
Vol 58
(1)
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pp. 48-49
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1980 ◽
Vol 5
(1)
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pp. 19-24
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