Colorimetric Determination of Terbutaline Sulfate and Orciprenaline Sulfate via Nitrosation and Difference Spectrophotometry

1987 ◽  
Vol 70 (3) ◽  
pp. 568-571 ◽  
Author(s):  
Mohamed E El-Sadek ◽  
Hisham E Abdel Latef ◽  
Afaf A Aboul Khier
Keyword(s):  
Hydrochloric Acid ◽  
Sodium Nitrite ◽  
Colorimetric Method ◽  
Dosage Forms ◽  
Alkaline Media ◽  
Colorimetric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Terbutaline Sulfate ◽  
The Difference

Abstract A colorimetric method is proposed for determination of terbutaline sulfate, orciprenaline sulfate, and their dosage forms. The suggested method depends on nitrosation of the 2 drugs by using sodium nitrite and hydrochloric acid. Addition of sodium hydroxide increases the intensity of the color developed. The difference between absorption values measured in acid and alkaline media is taken as a measure of concentration. Variables were carefully studied and optimized. Results for both compounds adhered to Beer's law over the range 2- 28 μg/mL. The method has proved to be accurate and precise for analysis of pharmaceutical dosage forms.

Colorimetric Determination of Acetylenic Hypnotics by Formation of Silver Acetylides

1980 ◽  
Vol 63 (1) ◽  
pp. 88-90
Author(s):  
Mohamed S Rizk ◽  
Mohamed I Walash ◽  
Amina El-Brashy
Keyword(s):  
Methyl Ketone ◽  
Good Accuracy ◽  
Colorimetric Method ◽  
Silver Ions ◽  
Dosage Forms ◽  
Colorimetric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Hypnotic Drugs ◽  
Silver Acetylide

Abstract A colorimetric method is described for the determination of certain mono-substituted acetylenic hypnotic drugs—ethinamate, methyl pentynol carbamate, and ethchlorvynol. Silver acetylide is formed and extracted into isobutyl methyl ketone. After acidification, an equivalent amount of silver ions is liberated which is assayed colorimetrically as silver dithizonate (λ max. 472 nm). About 10–50 μg compound could be assayed with good accuracy. The procedure is reproducible and precise (standard deviation 1.5–2.19%). The procedure was successfully applied to different pharmaceutical dosage forms.

COLORIMETRIC DETERMINATION OF CRUDE POWDERED MYRRH, PURIFIED MYRRH EXTRACT, OILY FRACTION, AND ITS DIFFERENT PHARMACEUTICAL DOSAGE FORMS

2002 ◽  
Vol 35 (2) ◽  
pp. 183-197 ◽  
Author(s):  
Mohamed H. Abdel-Hay ◽  
Amal Saleh ◽  
E. S. H. El Ashry ◽  
N. Rashed ◽  
Osama Salama
Keyword(s):  
Dosage Forms ◽  
Colorimetric Determination ◽  
Pharmaceutical Dosage Forms

Colorimetric Determination of Certain Phenothiazine Drugs by Using Morpholine and Iodine-Potassium Iodide Reagents

1986 ◽  
Vol 69 (3) ◽  
pp. 513-518 ◽  
Author(s):  
Adel F Youssef ◽  
Salwa R El-Shabouri ◽  
Fardous A Mohamed ◽  
Abdel Maboud I Rageh
Keyword(s):  
Potassium Iodide ◽  
Quantitative Estimation ◽  
Colorimetric Method ◽  
Molar Absorptivity ◽  
Dosage Forms ◽  
Colorimetric Determination ◽  
Reaction Products ◽  
Phenothiazine Drugs ◽  
Lower Molar

Abstract A colorimetric method was developed for the quantitative estimation of 11 phenothiazine drugs. The method is based on the interaction of unsulfoxidized drug with morpholine and iodine-potassium iodide reagents. The interaction for all studied phenothiazine drugs yields a blue product with 2 absorption maxima: one in the range of 620-640 nm with lower molar absorptivity and the other in the range of 662-690 nm with higher molar absorptivity. The color was stable for at least 10 h. The reproducibility and recovery of the method were excellent. The method was applied successfully to the analysis of various commercially available phenothiazines in different dosage forms. The results were comparable to those obtained by official procedures. The suitability of the method for detection and estimation of promethazine excreted in urine has been suggested by preliminary experiments. Reaction products have been isolated and identified.

scholarly journals Spectrophotometric quantification of dolutegravir based on redox reaction with Fe3+/1,10-phenanthroline

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Swathi Naraparaju ◽  
Durai Ananda Kumar Thirumoorthy ◽  
Sunitha Gurrala ◽  
Asra Jabeen ◽  
Pani Kumar D. Anumolu
Keyword(s):  
Redox Reaction ◽  
Quantitative Measurement ◽  
Colorimetric Method ◽  
Dosage Forms ◽  
Control Analysis ◽  
Colored Complex ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Quality Control Analysis

Abstract Background A simple and sensitive spectrophotometric method was developed for the quantitative measurement of dolutegravir in pure form and pharmaceutical formulation. The present method was based on redox reaction between dolutegravir and ferric chloride, which upon complexation with 1,10-phenanthroline formed an orange-colored complex that showed absorption maximum at 520.0 nm. Results The developed method obeyed linearity in the concentration range of 40.00–140.00 μg/mL. The method was also validated as per International Council for Harmonization guidelines and the results were within acceptance values. The validated method was employed for the determination of dolutegravir in pharmaceutical dosage form and the percentage assay value was found to be 102.5, which is in agreement with its label claimed. Conclusion The developed redox-based colorimetric method could be used in the routine quality control analysis of dolutegravir present in various pharmaceutical dosage forms.

Determination of Favipiravir from Pharmaceutical Dosage Form by Extractive Ion Pair Complex Colorimetric Method

2021 ◽  
pp. 321-323
Author(s):  
Rajan V. Rele ◽  
Prathamesh P. Tiwatane
Keyword(s):  
Standard Deviation ◽  
High Precision ◽  
Dosage Form ◽  
Colorimetric Method ◽  
Standard Addition ◽  
Dosage Forms ◽  
Ion Pair ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms

Simple sensitive and accurate extractive colorimetric method was developed for the estimation of favipiravir in Pharmaceutical dosage forms. The method was based on the formation of colored ion pair complexes by the drugs with thiocynate ions. These ion pair complexes were quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 618 respectively. The proposed method was validated statistically. A recovery of method was carried out by standard addition methods. The Beer’s law ranges were found to be 1-12μg/ml, respectively. The low values of standard deviation and percentage RSD indicate high precision of method. Hence the method is useful for routine estimation of favipiravir in tablets respectively.

Determination of Bismuth in Pharmaceutical Dosage Forms by Conventional DC Polarography

1972 ◽  
Vol 55 (1) ◽  
pp. 155-160
Author(s):  
William M Plank
Keyword(s):  
Standard Deviation ◽  
Relative Standard Deviation ◽  
Collaborative Study ◽  
Colorimetric Method ◽  
Dosage Forms ◽  
Official Method ◽  
Pharmaceutical Dosage Forms ◽  
Relative Standard ◽  
Dc Polarography

Abstract A method has been investigated for the determination of bismuth in pharmaceutical dosage forms by conventional dc polarography. The method is applicable to tablets, emulsions, suspensions, injectables, and bulk powders. A collaborative study has shown the method to be superior in accuracy and precision to the present official colorimetric method, 36.300- 36.304. The results from 16 determinations performed by 8 collaborators were: 100.0±1.5% recovery on a synthetic powder mix, a relative standard deviation of 1.9% on a commercial tablet sample, and a relative standard deviation of 2.1% on a magma sample. By comparison, the collaborative data reported for the present official method gave relative standard deviations of 3.4 and 3.2% on 2 samples of powder mixtures. It is recommended that the polarographic method be adopted as official first action.

scholarly journals Estimation of Some Antiviral Drugs Using Tpooo as Analytical Reagent

2006 ◽  
Vol 3 (3) ◽  
pp. 154-158 ◽  
Author(s):  
P. Venkata Reddy ◽  
B. Sudha Rani
Keyword(s):  
Hydrochloric Acid ◽  
Spectrophotometric Method ◽  
Dosage Forms ◽  
Antiviral Drugs ◽  
Organic Layer ◽  
Pharmaceutical Dosage Forms ◽  
Analytical Reagent

A simple and reproducible spectrophotometric method has been developed for the determination of two recent antiviral drugs namely Valacyclovir (drug A) and Famciclovir (drug B) in bulk and pharmaceutical dosage forms. The method is based on the extraction of the drugs into organic layer of the dye TPooo in presence of 0.1 N hydrochloric acid and the absorbances were measured at 490 nm. The method was optimized using eight parameters.

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