Organohalogen Residues in Human Adipose Autopsy Samples from Six Ontario Municipalities

1988 ◽  
Vol 71 (2) ◽  
pp. 410-414 ◽  
Author(s):  
David T Williams ◽  
Guy L Lebel ◽  
Elizabeth Junkins
Keyword(s):  
Adipose Tissue ◽  
Great Lakes ◽  
Pesticide Residues ◽  
Human Adipose Tissue ◽  
Frequency Of Occurrence ◽  
Tissue Samples ◽  
Male And Female

Abstract Human adipose tissue samples obtained during autopsies in 6 Canadian Great Lakes municipalities were analyzed for chlorobenzenes, polychlorobiphenyls, and organohalogen pesticide residues. The frequency of occurrence and the range and mean for 2JJ organohalogen residues are reported for male and female donors in each municipality. Overall mean residue values in females were significantly higher than those in males for hexachlorobenzen;, β-HCH, p,p'- DDE,»,/» -DDD + o,p'-DDT, and p,p'-DDT. The means and ranges of residue values were similar to those reported in previous Canadian surveys.

Polychlorinated dibenzodioxins and dibenzofurans in human adipose tissue samples from five Ontario municipalities

Chemosphere ◽  
1990 ◽  
Vol 21 (12) ◽  
pp. 1465-1475 ◽  
Author(s):  
Guy L. LeBel ◽  
David T. Williams ◽  
Frank M. Benoit ◽  
Michael Goddard
Keyword(s):  
Adipose Tissue ◽  
Human Adipose Tissue ◽  
Tissue Samples ◽  
Polychlorinated Dibenzodioxins

Investigation of pesticide residues in human adipose tissue in the northeast Louisiana area

1980 ◽  
Vol 28 (1) ◽  
pp. 76-78 ◽  
Author(s):  
Earl S. Greer ◽  
Donald J. Miller ◽  
Frank N. Bruscato ◽  
Robert L. Holt
Keyword(s):  
Adipose Tissue ◽  
Pesticide Residues ◽  
Human Adipose Tissue

Accumulation levels and characteristics of some pesticides in human adipose tissue samples from Southeast China

Chemosphere ◽  
2011 ◽  
Vol 84 (7) ◽  
pp. 964-971 ◽  
Author(s):  
Na Wang ◽  
Lili Shi ◽  
Deyang Kong ◽  
Daoji Cai ◽  
Yanzhong Cao ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Human Adipose Tissue ◽  
Tissue Samples ◽  
Southeast China

scholarly journals Retinoic acid and vitamin D(3) powerfully inhibit in vitro leptin secretion by human adipose tissue

2001 ◽  
Vol 170 (2) ◽  
pp. 425-431 ◽  
Author(s):  
C Menendez ◽  
M Lage ◽  
R Peino ◽  
R Baldelli ◽  
P Concheiro ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Retinoic Acid ◽  
Energy Homeostasis ◽  
Human Adipose Tissue ◽  
Tissue Samples ◽  
Omental Adipose Tissue ◽  
Vitamin D 3 ◽  
Gender Based

Leptin, the product of the ob gene, is secreted into the circulation by white adipose tissue; its major role being to participate in the regulation of energy homeostasis. Plasma leptin levels are mainly determined by the relative adiposity of the subject; however, the great dispersion of values for any given body mass index and the noteworthy gender-based differences indicate that other factors are operating. Steroid hormones actively participate in the regulation of leptin secretion; however, non-steroid nuclear hormones have either not been studied or have provided contradictory results. In order to understand the role of hormones of the non-steroid superfamily such as 3,5,3'-tri-iodothyronine (T(3)), vitamin D(3) and retinoic acid (RA) in the control of leptin secretion, in the present work doses of 10(-9), 10(-8) and 10(-7) M of these compounds have been studied on in vitro leptin secretion. The organ culture was performed with omental adipose tissue samples from healthy donors (n=28). T(3) was devoid of effect at any dose studied, while an inhibition of leptin secretion was observed with 9-cis-RA (slight) and all-trans-RA (potent). Interestingly, vitamin D(3) exerted a powerfully inhibitory role at the doses studied, and its action was synergistic with all-trans-RA. In conclusion, in vitro leptin secretion by human adipose tissue is negatively controlled by either RA or vitamin D(3). The clinical significance of leptin regulation by this superfamily of nuclear receptors remains to be ascertained.

Hexabromocyclododecanes in human adipose tissue from Japan

2009 ◽  
Vol 6 (4) ◽  
pp. 328 ◽  
Author(s):  
Tomohiko Isobe ◽  
Hiroko Oda ◽  
Nozomi Takayanagi ◽  
Tatsuya Kunisue ◽  
Hiroaki Komori ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Polybrominated Diphenyl Ethers ◽  
Regional Differences ◽  
Flame Retardants ◽  
Human Adipose Tissue ◽  
Tissue Samples ◽  
Diphenyl Ethers ◽  
Age Dependent ◽  
Residue Levels ◽  
Kanto Region

Environmental context. Contamination by hexabromocyclododecanes (HBCDs), a group of brominated flame retardants, is of great concern due to their bioaccumulative nature and toxic implications. HBCD consumption in Japan is the highest among Asian countries and is still growing. In this regard, human exposure to HBCDs is of great concern in Japan. We present here the results of our investigation on Japanese human adipose tissue using LC-MS/MS. HBCDs were detected in all the samples analysed, and were generally higher in men than in women. Abstract. Residue levels of hexabromocyclododecanes (HBCDs) were measured using LC-MS/MS in the Japanese human adipose tissue samples collected during 2003–2004 from Ehime prefecture (n = 26) and Kanto region (n = 9) of Japan. Concentrations of HBCDs (0.85–39 ng g–1 lipid) in the adipose tissue samples were 1–2 orders of magnitude lower than those of organochlorines (OCs). Regional differences between HBCD levels in Ehime prefecture and Kanto region were not significant. No age-dependent accumulation of HBCDs was observed. HBCD levels in men were significantly higher than those in women. Significant positive correlation between polybrominated diphenyl ethers (PBDEs) and HBCDs implies similar routes of exposure to these contaminants for Japanese citizens. α-HBCD was predominant among the three isomers, which is consistent with the other reports on bioaccumulation of α-HBCD in higher trophic animals.

scholarly journals Response of the adipose tissue transcriptome to dihydrotestosterone in mice

2008 ◽  
Vol 35 (3) ◽  
pp. 254-261 ◽  
Author(s):  
Yonghua Zhang ◽  
Ezequiel Calvo ◽  
Céline Martel ◽  
Van Luu-The ◽  
Fernand Labrie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cell Function ◽  
Kinase Inhibitor ◽  
Control Group ◽  
Peak Time ◽  
Fat Cell ◽  
Tissue Samples ◽  
Male And Female ◽  
Female Mice ◽  
Retroperitoneal Adipose Tissue

Androgens have been postulated to be important modulators of adipose tissue metabolism and fat cell function. In the present study, we investigated the response of male and female mice retroperitoneal adipose tissue to the nonaromatizable androgen dihydrotestosterone (DHT). Adipose tissue samples were obtained in gonadectomized animals treated with vehicle (control group), or injected with 0.1 mg DHT 1, 3, 6, 12, 18, and 24 h prior to necropsy. Fourteen animals were pooled at each time point (total 196 animals). Transcripts that were significantly modulated were considered as androgen-responsive genes. Quantitative real-time RT-PCR was used to confirm results from the microarray analysis in a subset of 46 probe sets in male mice and 98 probe sets in female mice. Considering peak time vs. control, we confirmed 74.0 and 63.3% of the modulated genes by PCR in males and females, respectively. Four genes were significantly stimulated in a similar manner by DHT in both sexes, namely metallothionein 1, growth arrest and DNA-damage-inducible 45 gamma, cyclin-dependent kinase inhibitor 1A, and fk506-binding protein 5. All these genes appear to be involved in the regulation of adipocyte differentiation/proliferation and adipogenesis. In conclusion, this study, which evaluated the acute transcriptome response of adipose tissue to DHT in male and female mice, suggests that DHT consistently modulates genes involved in the regulation of adipogenesis in retroperitoneal adipose tissue of both male and female animals.

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