scholarly journals Determination of Phenylephrine Hydrochloride by Flow Injection Analysis with Chemiluminescence Detection

2001 ◽  
Vol 84 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Yolanda Fuster Mestre ◽  
Luis Lahuerta Zamora ◽  
José Martínez Calatayud
Keyword(s):  
Flow Injection ◽  
Flow Injection Analysis ◽  
Pharmaceutical Formulations ◽  
Calibration Graph ◽  
Chemiluminescence Detection ◽  
Phenylephrine Hydrochloride ◽  
Sulfuric Acid Medium ◽  
Sample Throughput ◽  
Relative Standard

Abstract A new method is proposed for the determination of phenylephrine hydrochloride by flow injection analysis with direct chemiluminescence detection. The method is based on the oxidation of the drug by potassium permanganate in sulfuric acid medium at 80°C. The calibration graph is linear over the range 0.03–8 ppm phenylephrine hydrochloride, with a relative standard deviation (n = 51, 0.5 ppm) of 1.1% and sample throughput of 134/h. The influence of 38 different foreign compounds was tested, and the method was applied to the determination of phenylephrine hydrochloride in 8 different pharmaceutical formulations.

Flow-injection analysis with chemiluminescence detection.

1979 ◽  
Vol 25 (9) ◽  
pp. 1635-1638 ◽  
Author(s):  
G Rule ◽  
W R Seitz
Keyword(s):  
Flow Injection ◽  
Flow Injection Analysis ◽  
Detection System ◽  
Sample Volume ◽  
Chemiluminescence Detection ◽  
Cupric Ion ◽  
Peak Overlap ◽  
Sample Throughput ◽  
Relative Standard ◽  
Replicate Measurements

Abstract In "flow-injection analysis," the sample is inserted into a stream of reagent by use of a sample-injection valve. Mixing occurs downstream from the valve in a coil of tubing. With chemiluminescence detection this coil is positioned in front of a photomultiplier. We have evaluated the system for detection of hydrogen peroxide, using the luminol reaction with cupric ion as a catalyst. The effects of flow rate, sample volume, and reaction kinetics on the magnitude, duration, and repeatability of the chemiluminescent response have been evaluated. Precisions of 1 to 2% relative standard deviation on replicate measurements are readily achievable. A sample throughput of six samples per minute is possible with very little peak overlap. This detection system can be coupled to any process in which peroxide is generated.

scholarly journals Spectrophotometric flow injection procedure to indirect determination of paracetamol in pharmaceutical formulations using o-tolidine as reagent

2018 ◽  
Vol 33 (2) ◽  
pp. 47
Author(s):  
Orlando Fatibello-Filho ◽  
Heberth Juliano Vieira
Keyword(s):  
Standard Deviation ◽  
Detection Limit ◽  
Flow Injection ◽  
Pharmaceutical Formulations ◽  
Injection Method ◽  
Indirect Determination ◽  
Analytical Curve ◽  
Relative Standard ◽  
Injection Procedure

A spectrophotometric flow injection method for the determination of paracetamol in pharmaceutical formulations is proposed. The procedure was based on the oxidation of paracetamol by sodium hypochloride and the determination of the excess of this oxidant using o-tolidine dichloride as chromogenic reagent at 430 nm. The analytical curve was linear in the paracetamol concentration range from 8.50 x 10-6 to 2.51 x 10-4 mol L-1 with a detection limit of 5.0 x 10-6 mol L-1. The relative standard deviation was smaller than 1.2% for 1.20 x 10-4 mol L-1 paracetamol solution (n = 10). The results obtained for paracetamol in pharmaceutical formulations using the proposed flow injection method and those obtained using a USP Pharmacopoeia method are in agreement at the 95% confidence level.

Automated multiple flow-injection analysis in clinical chemistry: determination of albumin with bromcresol green.

1980 ◽  
Vol 26 (2) ◽  
pp. 331-334 ◽  
Author(s):  
B W Renoe ◽  
K K Stewart ◽  
G R Beecher ◽  
M R Wills ◽  
J Savory
Keyword(s):  
Standard Deviation ◽  
Relative Standard Deviation ◽  
Flow Injection ◽  
Flow Injection Analysis ◽  
Clinical Chemistry ◽  
Analytical Results ◽  
Relative Standard ◽  
Clinical Chemical ◽  
Bromcresol Green

Abstract We describe an adaptation of automated multiple flow-injection analysis instrumentation to an analysis for albumin in serum. The bromcresol green reaction was used to test the utility of the system. The approach yielded albumin results with excellent sensitivity, no measurable carryover, a relative standard deviation of less than 1%, good correlations with published procedures, and no measurable interferences. The simplicity and flexibility of the instrumentation and its performance integrity, as indicated by the analytical results, make this a viable clinical chemical tool.

Determination of Total Arsenic and Selenium in Soils and Plants by Atomic Absorption Spectrometry with Hydride Generation and Flow Injection Analysis Coupled Techniques

1996 ◽  
Vol 79 (3) ◽  
pp. 764-768 ◽  
Author(s):  
Oroncio Jiménez De Blas ◽  
N Rodriguez Mateos ◽  
A Garcia Sanchez
Keyword(s):  
Atomic Absorption Spectrometry ◽  
Atomic Absorption ◽  
Flow Injection ◽  
Flow Injection Analysis ◽  
Hydride Generation ◽  
Absorption Spectrometry ◽  
Sample Treatment ◽  
Total Arsenic ◽  
Relative Standard

Abstract A procedure has been developed for determination of total arsenic and selenium in soils and plants by atomic absorption spectrometry with hydride generation associated with flow injection analysis (FIA-AAS-HG). Samples were wet-digested by using 2 systems: heating in a metal digestion block with controlled temperature and time and heating in a microwave oven. Total arsenic and selenium were reduced with NaBH4 and concentrated HCI, respectively. In both digestion systems used for the 2 matrix types, detection limits below 1 μg/L were found for both elements for an injection volume of 160 μL, with relative standard deviations of 3–6%. Recoveries by the method ranged from 93 to 105%; with the reference materials FD8 and MRG-1, the values obtained in all cases were consistent with the certified data. The FIA-AAS-HG procedure is highly suitable for determination of total arsenic and selenium in soils and plants, and because of the coupled system used, it is an improvement over other procedures in terms of sample treatment, sample consumption, and automation.

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