248 The detrimental effect of pregnancy-associated bile acid homeostasis disorder on fetal pig death.

Transplantation of cardiomyocytes into the heart is a potential treatment for replacing damaged cardiac muscle. To investigate the feasibility and efficiency of this technique, either a cardiac-derived cell line (HL-1 cells), or normal fetal or neonatal pig cardiomyocytes were grafted into a porcine model of myocardial infarction. The myocardial infarction was created by the placement of an embolization coil in the distal portion of the left anterior descending artery in Yorkshire pigs (n = 9). Four to 5 wk after creation of an infarct, the three preparations of cardiomyocytes were grafted, at 1 × 106 cells/20 μL into normal and into the middle of the infarcted myocardium. The hearts were harvested and processed for histologic examinations 4 to 5 wk after the cell grafts. Histologic evaluation of the graft sites demonstrated that HL-1 cells and fetal pig cardiomyocytes formed stable grafts within the normal myocardium without any detrimental effect including arrhythmia. In addition, a marked increase in angiogenesis was observed both within the grafts and adjacent host myocardium. Electron microscopy studies demonstrated that fetal pig cardiomyocytes and the host myocardial cells were coupled with adherens-type junctions and gap junctions. Histologic examination of graft sites from infarct tissue failed to show the presence of grafted HL-1 cells, fetal, or neonatal pig cardiomyocytes. Cardiomyocyte transplantation may provide the potential means for cell-mediated gene therapy for introduction of therapeutic molecules into the heart.

Download Full-text

Bile acid stimulation of small bile duct proliferation requires de novo expression of the apical bile acid transporter (ABAT)

Gastroenterology ◽

10.1016/s0016-5085(01)80006-8 ◽

2001 ◽

Vol 120 (5) ◽

pp. A1-A1

Author(s):

G ALPINI ◽

S GLASER ◽

J PHINIZY ◽

N KANNO ◽

H FRANCIS ◽

...

Keyword(s):

Bile Acid ◽

Bile Duct ◽

De Novo ◽

Bile Duct Proliferation ◽

Bile Acid Transporter ◽

Small Bile Duct ◽

Acid Transporter ◽

Stimulation Of

Download Full-text

Cognitive Load Mediates the Effect of Emotion on Analytical Thinking

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000333 ◽

2016 ◽

Vol 63 (6) ◽

pp. 343-350 ◽

Cited By ~ 5

Author(s):

Bastien Trémolière ◽

Marie-Ève Gagnon ◽

Isabelle Blanchette

Keyword(s):

Cognitive Load ◽

Secondary Task ◽

Deleterious Effect ◽

Detrimental Effect ◽

Emotional Problems ◽

Syllogistic Reasoning ◽

Cognitive Resources ◽

Potential Explanation ◽

Cognitive Mechanism ◽

Analytical Thinking

Abstract. Although the detrimental effect of emotion on reasoning has been evidenced many times, the cognitive mechanism underlying this effect remains unclear. In the present paper, we explore the cognitive load hypothesis as a potential explanation. In an experiment, participants solved syllogistic reasoning problems with either neutral or emotional contents. Participants were also presented with a secondary task, for which the difficult version requires the mobilization of cognitive resources to be correctly solved. Participants performed overall worse and took longer on emotional problems than on neutral problems. Performance on the secondary task, in the difficult version, was poorer when participants were reasoning about emotional, compared to neutral contents, consistent with the idea that processing emotion requires more cognitive resources. Taken together, the findings afford evidence that the deleterious effect of emotion on reasoning is mediated by cognitive load.

Download Full-text