scholarly journals PSXIV-12 Impact of prebiotic and probiotic feed additive blends on bovine respiratory disease, E. coli O157:H7 shedding, and performance of receiving steers.

2018 ◽  
Vol 96 (suppl_3) ◽  
pp. 440-440
Author(s):  
D Paulus Compart ◽  
U Anele ◽  
C Engel ◽  
D Vyas ◽  
D Kim ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Feed Additive ◽  
E Coli ◽  
And Performance

86 Effect of Post-metaphylactic Interval on Health and Performance of Steers Administered Tildipirosin for the Control of Bovine Respiratory Disease

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 5-5
Author(s):  
Marshall N Streeter ◽  
Josh Szasz ◽  
Tony C Bryant
Keyword(s):  
Body Weight ◽  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Beef Steers ◽  
Linear Quadratic ◽  
Moderate Risk ◽  
Final Body Weight ◽  
Treatment Data ◽  
Carcass Performance ◽  
And Performance

Abstract Crossbred beef steers (n = 8160; 294 + 10.4 kg) were used in a randomized complete block designed study to determine the effects of post-metaphylactic interval (PMI) on health, live and carcass performance. Steers were administered tildipirosin for the control of bovine respiratory disease (BRD) before being randomly allocated to PMI treatments (4-, 7-, 10-, or 13-day PMI). Treatments were replicated in forty - 204 head pens with each treatment represented within 10 arrival blocks. Blocks ranged from 4 to 15 unique sources of cattle representing five states (AR, FL, GA, LA, TX). Steers were observed daily (217 + 14 d) by trained pen riders with steers suffering from BRD receiving a common antibiotic therapy across PMI treatment. Data were evaluated using linear, quadratic and cubic contrasts. First pull BRD morbidity decreased linearly (P < 0.01) and tended to decrease quadratically (P = 0.08) as PMI increased with the greatest BRD morbidity at 7 days (12.9%) and the least at 13 days (9.5%). First pull BRD relapses tended to decrease linearly (P = 0.10) with increasing PMI. Total first pull morbidity, for all causes, decreased quadratically (P = 0.02) as PMI increased with the greatest morbidly occurring with a 7-day PMI (15.8%) and the least with a 13-day PMI (11.5%). Mortality caused by BRD (0.73%; P > 0.70) and all causes (1.41%; P > 0.20) or chronicity (1.60%; P > 0.15), resulting from failure to respond to therapy, were not affected by PMI. Final body weight, ADG, DMI, Gain:Feed, and HCW were not affected (P > 0.20) by PMI. Total and BRD morbidity can be reduced by increasing PMI up to 13 days in cattle at moderate risk of developing BRD (15% morbidity, 1% mortality, 1% chronicity) without adversely affecting mortality, chronicity or live and carcass performance.

scholarly journals Net return distributions when metaphylaxis is used to control bovine respiratory disease in high health-risk cattle

2020 ◽  
Vol 4 (2) ◽  
pp. 1091-1102
Author(s):  
Elliott J Dennis ◽  
Ted C Schroeder ◽  
David G Renter
Keyword(s):  
Health Risk ◽  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Performance Outcomes ◽  
Feedlot Cattle ◽  
Net Return ◽  
Lower Tier ◽  
Net Returns ◽  
Return Distributions ◽  
And Performance

Abstract This study’s objective was to estimate net returns and return risk for antimicrobial metaphylaxis options to manage bovine respiratory disease (BRD) in high health-risk feedlot cattle. The effectiveness of antimicrobials for metaphylaxis varies by cattle population. How differing antimicrobial effectiveness translates to net return profitability for heterogeneous cattle populations is less understood. Net returns and return risk were assessed using a net return simulation model adapted to allow for heterogeneity in high health-risk cattle placement characteristics and antimicrobial choice to control BRD. The net return model incorporated how antimicrobials modify BRD health and performance outcomes. Health and performance outcomes were calibrated from published literature and proprietary feedlot data. Proprietary data came from 10 Midwestern feedlots representing nearly 6 million animals and 50,000 cohorts. Twelve placement-by-metaphylaxis decision combinations were assessed: high health-risk steer placement demographics were 600 or 800 lb steers placed in Winter (Oct–Mar) or Summer (Apr–Sept) managed with one of three different health programs: “no metaphylaxis,” “Upper Tier” antimicrobial, or “Lower Tier” antimicrobial. Net return distributions were compared between “no metaphylaxis” and a specific antimicrobial tier within specific cattle populations. We found the expected incremental net return of administering an “Upper Tier” (“Lower Tier”) antimicrobial for metaphylaxis compared to “no metaphylaxis” for high health-risk steers was $122.55 per head ($65.72) for 600 lb and $148.65 per head ($79.65) for 800 lb winter placements. The incremental expected net return and risk mitigated by metaphylaxis varied by placement weight, season, and antimicrobial choice. The probability net returns would decline by at least $50 per head was significantly reduced (from approximately 4% to 40%) when any antimicrobial was used on high health-risk steers. Both tiers of antimicrobials used for metaphylaxis increased expected net returns and decreased net return variability relative to no metaphylaxis. Thus, feedlots were more certain and realize a greater profit on high health-risk pens of steers when metaphylaxis was used. This occurred because the reduction in cattle health and performance outcomes using any antimicrobial was sufficiently large to cover added initial and subsequent antimicrobial costs. Results aid in assessing metaphylaxis strategies in high health-risk cattle.

scholarly journals Applicability and performance of EUCAST’s rapid antimicrobial susceptibility testing (RAST) on primarily sterile body fluids in blood culture bottles in laboratory routine with total lab automation

2021 ◽  
Author(s):  
Jasmin Kaur Jasuja ◽  
Stefan Zimmermann ◽  
Irene Burckhardt
Keyword(s):  
Blood Culture ◽  
Susceptibility Testing ◽  
Reference Method ◽  
Body Fluids ◽  
E Coli ◽  
Mueller Hinton ◽  
Mueller Hinton Agar ◽  
And Performance ◽  
Sterile Body Fluids ◽  
Better Than

AbstractOptimisation of microbiological diagnostics in primarily sterile body fluids is required. Our objective was to apply EUCAST’s RAST on primarily sterile body fluids in blood culture bottles with total lab automation (TLA) and to compare results to our reference method Vitek2 in order to report susceptibility results earlier. Positive blood culture bottles (BACTEC™ Aerobic/Anaerobic/PEDS) inoculated with primarily sterile body fluids were semi-automatically subcultured onto Columbia 5% SB agar, chocolate agar, MacConkey agar, Schaedler/KV agar and Mueller-Hinton agar. On latter, cefoxitin, ampicillin, vancomycin, piperacillin/tazobactam, meropenem and ciprofloxacin were added. After 6 h, subcultures and RAST were imaged and MALDI-TOF MS was performed. Zone sizes were digitally measured and interpreted following RAST breakpoints for blood cultures. MIC values were determined using Vitek2 panels. During a 1-year period, 197 Staphylococcus aureus, 91 Enterococcus spp., 38 Escherichia coli, 11 Klebsiella pneumoniae and 8 Pseudomonas aeruginosa were found. Categorical agreement between RAST and MIC was 96.5%. Comparison showed no very major errors, 2/7 (28.6%) and 1/7 (14.3%) of major errors for P. aeruginosa and meropenem and ciprofloxacin, 1/9 (11.1%) for K. pneumoniae and ciprofloxacin, 4/69 (7.0%) and 3/43 (5.8%) for Enterococcus spp. and vancomycin and ampicillin, respectively. Minor errors for P. aeruginosa and meropenem (1/8; 12.8%) and for E. coli and ciprofloxacin (2/29; 6.5%) were found. 30/550 RAST measurements were within area of technical uncertainty. RAST is applicable and performs well for primarily sterile body fluids in blood culture bottles, partially better than blood-based RAST. Official EUCAST evaluation is needed.

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