scholarly journals 10 A field study to investigate the effect of Zuprevo administered alone or in combination with banamine transdermal on the health and well-being of transported feedlot calves on arrival at the feedlot

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 6-6
Author(s):  
Miriam S Martin ◽  
Michael Kleinhenz ◽  
Katie Kleinhenz ◽  
Emily Reppert ◽  
Dale Blasi ◽  
...  
Keyword(s):  
Drug Application ◽  
Computer Software ◽  
Well Being ◽  
Morbidity And Mortality ◽  
Accelerometer Data ◽  
Long Distance ◽  
Long Distance Transport ◽  
Increased Risk ◽  
Vas Scores ◽  
Feedlot Calves

Abstract Long distance transportation can be a significant source of stress to cattle and is associated with increased risk of bovine respiratory disease (BRD). The administration of a nonsteroidal anti-inflammatory drug (NSAID) has been shown to reduce stress following long distance transport. The objective of this study was to compare production parameters, morbidity, and mortality between calves receiving either tildipirosin alone or in combination with transdermal flunixin on arrival at the feedlot. 384 head of polled, Continental x English and English crossbred bulls and steers were enrolled into one of two treatments: 1) tildipirosin only (PLBO) 2) tildipirosin in combination with transdermal flunixin (FTD). Tildipirosin was administered in the neck as a single dose of 4 mg/kg alone, or in combination with transdermal flunixin applied to the dorsal midline at the label dose of 3.3 mg/kg. Outcomes measured were performance parameters, dry mater intake and feed efficiency, morbidity and mortality, pen pulls and treatments, a daily visual analog scale (VAS) assessment and accelerometer data. Statistical analysis was performed using computer software (JMP 13, SAS Institute, Cary, NC). There were no significant differences in average lot weights between treatment groups (P = 0.415). There were no treatment effects on the determined dry matter intake (P = 0.51). There were no significant differences observed in morbidity and mortality between groups (P = 0.292). VAS pain assessment showed significant differences for time (P < 0.0001) and time by treatment interaction (P < 0.0001), with FTD calves having lower (VAS) scores. There were no significant differences between treatments for the acceleration data (P = 0.190). Calves administered transdermal flunixin had lower VAS scores indicating less pain the first 36 hours after drug application. Over the 63-d feeding period, no advantages in performance were observed following FTD administration.

scholarly journals Comparison of the effect of tildipirosin administered alone or in combination with transdermal flunixin on the performance, health, activity, and well-being of transported feedlot calves on arrival at the feedlot

2020 ◽  
Vol 4 (1) ◽  
pp. 452-459
Author(s):  
Miriam Martin ◽  
Michael Kleinhenz ◽  
Katie Kleinhenz ◽  
Emily Reppert ◽  
Dale Blasi ◽  
...  
Keyword(s):  
Animal Health ◽  
Average Daily Gain ◽  
Computer Software ◽  
Random Variable ◽  
Well Being ◽  
Experimental Unit ◽  
Long Distance ◽  
Activity Data ◽  
Long Distance Transport ◽  
Increased Risk

Abstract Long distance transportation can be a significant source of stress to cattle and is associated with increased risk of bovine respiratory disease (BRD). The administration of a nonsteroidal anti-inflammatory drug (NSAID) has been shown to reduce stress following long distance transport. The objective of this study was to compare performance, health, accelerometer activity, and well-being between calves receiving either tildipirosin (Zuprevo 18%; Merck Animal Health, Madison, NJ) alone or in combination with transdermal flunixin (BANAMINE Transdermal Pour-on Solution; Merck Animal Health, Madison, NJ) on arrival at the feedlot. Three hundred eighty-four polled, Continental × English, and English crossbred bulls (n = 199) and steers (n = 185) were enrolled into one of two treatments: 1) tildipirosin administered in the neck as a single dose of 4 mg/kg only (PLBO) 2) tildipirosin in combination with transdermal flunixin applied to the dorsal midline at a dose of 3.3 mg/kg (FTD). Outcomes measured were average daily gain (ADG), dry mater intake (DMI), gain to feed, morbidity, mortality, accelerometer activity data, and a daily visual analog scale (VAS) assessment of well-being. Body weight (BW) was determined by weighing individual animals; ADG was calculated as initial BW—final BW / total days on feed; DMI was calculated as daily pen feed allocation—feed remaining at next feeding / number of calves in the pen; and gain to feed was calculated as pen level ADG / pen level DMI. The VAS used was a 100 mm line anchored at each end by descriptors of “no pain” or “severe pain”. Statistical analysis was performed using JMP 13 computer software using pen as the experimental unit, lot number as a random variable, and treatment as a fixed variable. There was no treatment effect on DMI (P = 0.51). During the first 14 d on feed, FTD calves had a lower ADG of 0.90 kg/d compared with 1.33 kg/d in the PLBO group (P = 0.05). There were no differences observed in morbidity and mortality between groups (P = 0.29). There were no treatment differences from activity data (P = 0.19). The VAS assessment showed a significant time × treatment interaction (P &lt; 0.001). During the first 36 h after treatment administration, the FTD-treated calves had lower VAS scores [6.23 (95% CI: 5.27–7.20) compared with 7.28 (95% CI: 6.32–8.24)] than PLBO (P &lt; 0.05). Results suggest that FTD-treated calves showed less signs of pain the first 36 h postdrug application relative to PLBO calves.

Abstract P087: Association of Psychological Well-Being With Cardiac Repolarization

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amit J Shah ◽  
Robert Carney ◽  
Elsayed Z Soliman ◽  
Viola Vaccarino
Keyword(s):  
Psychological Health ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Well Being ◽  
Left Ventricular ◽  
Morbidity And Mortality ◽  
Psychological Well Being ◽  
Psychological Wellness ◽  
Increased Risk ◽  
The Mean

Background: Abnormal frontal T-axis is an independent predictor of mortality, and may be influenced by increased sympathetic tone and cardiovascular disease risk factors. Factors related to poor psychological health, such as depression, are associated with increased risk of CVD morbidity, although the mechanisms are not clear. We tested the hypothesis that: 1) reduced psychological wellness is associated with abnormal T-axis and 2) this association may help to explain the excess risk of CVD morbidity and mortality related to poor psychological health. Methods: We studied 4485 community-based adults aged 25–65 years without a history of CVD from NHANES I (1971–75) who were monitored for CVD hospitalization and death until 1993. Those with ECG evidence of previous MI, left ventricular hypertrophy, and major ventricular conduction defects (QRS interval ≥ 120 ms) were excluded. Frontal T-axis was obtained through 12-lead ECG, and a deviation of ≥ 30° from normal (45°) was considered abnormal. Psychological well-being was measured with the General Well-Being Scale (GWB). Results: The mean ± SD age was 43.1 ± 11.5 years and 55% were women. The mean ± SD GWB score was 80.5 ± 17.3, the median frontal T-axis was 51°, and 13% had an abnormal T-axis. In cross-sectional analysis adjusting for age, sex, and race, a 1-SD decrease in GWB was associated with an OR of 1.12 for abnormal T-axis (p=0.01). This effect was unchanged after adjusting for systolic blood pressure, smoking, diabetes, total cholesterol, and BMI. Abnormal T-axis was associated with CVD hospitalization/death (adjusted HR 1.29, p=0.01), as was GWB (adjusted HR 1.104 per 1-SD decrease, p=0.01). When both factors were included in the model, the HR of GWB decreased by 8% to 1.096 (p=0.02). Conclusion: Abnormal frontal T-axis is modestly but significantly associated with reduced psychological wellness. Although this association may help understand neurocardiac relationships, it does not substantially explain morbidity and mortality associated with reduced psychological wellness.

Effect of space allowance during transport on the behavioural and physiological responses of sheep

1995 ◽  
Vol 1995 ◽  
pp. 171-171
Author(s):  
M.S. Cockram ◽  
J.E. Kent ◽  
N.K. Waran ◽  
R.E. Jackson ◽  
G.M. Muwanga ◽  
...  
Keyword(s):  
Physiological Responses ◽  
Plasma Concentrations ◽  
Plasma Osmolality ◽  
Live Weight ◽  
Farm Animals ◽  
Long Distance ◽  
Potentially Traumatic Events ◽  
Long Distance Transport ◽  
Increased Risk ◽  
Acceleration Sensors

When farm animals are transported over long distances there is concern about their welfare. This has resulted in consumer pressure and additional legislation to control the transport of animals. However, information on the behavioural and physiological responses of sheep to transport is required to assess which aspects of transport can cause welfare problems. An optimal space allowance for long distance transport of sheep should ideally provide stability; allow normal posture (during standing and lying), and postural adjustments, without causing an increased risk of injury and psychological ‘stress’. Direct behavioural observations of potentially traumatic events related to vehicle movement and behavioural interactions (riding and trampling) were recorded during transport. Postures, orientation, rumination and eating were recorded to determine whether there was sufficient space to lie down during transport and to assess the relative priorities for resting and eating post-transport. Measurements of ‘stress’ (heart rate and plasma concentrations of Cortisol); injury (plasma activities of creatinine kinase and aspartate aminotransferase, and acceleration sensors), and dehydration (packed cell volume, plasma osmolality, plasma concentrations of total protein, vasopressin and sodium, water intake and live-weight change) were also made.

The Fine Structure of Phloem Cells

1985 ◽  
Vol 43 ◽  
pp. 632-635
Author(s):  
James Cronshaw
Keyword(s):  
Structural Studies ◽  
High Concentration ◽  
Long Distance ◽  
Phloem Tissue ◽  
Sieve Elements ◽  
Long Distance Transport ◽  
P Protein ◽  
Companion Cells ◽  
Electron Microscopical ◽  
Distance Transport

Long distance transport in plants takes place in phloem tissue which has characteristic cells, the sieve elements. At maturity these cells have sieve areas in their end walls with specialized perforations. They are associated with companion cells, parenchyma cells, and in some species, with transfer cells. The protoplast of the functioning sieve element contains a high concentration of sugar, and consequently a high hydrostatic pressure, which makes it extremely difficult to fix mature sieve elements for electron microscopical observation without the formation of surge artifacts. Despite many structural studies which have attempted to prevent surge artifacts, several features of mature sieve elements, such as the distribution of P-protein and the nature of the contents of the sieve area pores, remain controversial.

Adenocarcinoma of the Appendix in Elderly: Diagnostic dilemma

2020 ◽  
Vol 01 ◽  
Author(s):  
Heba Nofal ◽  
Hayder Al-Masari ◽  
Marwan Mohammed Rashed ◽  
Reham Ainawi ◽  
Desh Idnani ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Ct Scan ◽  
Laparoscopic Appendectomy ◽  
Signs And Symptoms ◽  
Morbidity And Mortality ◽  
Diagnostic Dilemma ◽  
Increased Risk

: Acute appendicitis in elderly continue to be a diagnostic dilemma as it raises both the suspicion of malignancy and increased risk of morbidity and mortality. Cancers of the appendix are rare and most of them are found accidentally on appendectomies performed for acute appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Adenocarcinomas of appendix are only 0.08% of all cancers and the treatment remains controversial. This paper presents a case of 75-year-old female presented to emergency (ER) with signs and symptoms mimicking acute appendicitis, laparoscopic appendectomy was planned after a CT scan was done as it was suggesting acute appendicitis. The specimen then was sent foe pathology lab and a diagnosis of adenocarcinoma of the appendix was made.

Prevalence of Asymptomatic Cryptococcal Antigenemia and Association with Follow-up risk of Cryptococcal Meningitis and Mortality among HIV Infected Patients in North West India – A Prospective Cohort Study

2020 ◽  
Vol 18 ◽  
Author(s):  
Rajendra Bhati ◽  
Pramendra Sirohi ◽  
Bharat Sejoo ◽  
Deepak Kumar ◽  
Gopal K Bohra ◽  
...  
Keyword(s):  
Cryptococcal Meningitis ◽  
Morbidity And Mortality ◽  
People Living With Hiv ◽  
Cryptococcal Antigen ◽  
North West ◽  
Cryptococcal Disease ◽  
Increased Risk ◽  
Living With Hiv ◽  
Inflammatory Syndrome

Objective: Cryptococcal meningitis is an important cause of morbidity and mortality in HIV infected individuals. In the era of universal antiretroviral therapy incidence of immune reconstitution inflammatory syndrome (IRIS) related cryptococcal meningitis has increased. Detection of serum cryptococcal antigen in asymptomatic PLHIV (People Living With HIV) and pre-emptive treatment with fluconazole can decrease the burden of cryptococcal disease. We conducted this study to find the prevalence of asymptomatic cryptococcal antigenemia in India and its correlation with mortality in PLHIV. Method and material: This was a prospective observational study. HIV infected ART naïve patients with age of ≥ 18 years who had CD4 counts ≤ 100 /µL were included and serum cryptococcal antigen test was done. These patients were followed for six months to look for the development of Cryptococcal meningitis and mortality. Results: A total of 116 patients were analysed. Asymptomatic cryptococcal antigenemia was detected in 5.17% patients and it correlated with increased risk of cryptococcal meningitis and mortality on follow-up in PLHIV. Conclusion: Serum cryptococcal positivity is correlated with increased risk of Cryptococcal meningitis and mortality in PLHIV. We recommend the screening of asymptomatic PLHIV with CD4 ≤ 100/µL for serum cryptococcal antigen, so that pre-emptive treatment can be initiated to reduce morbidity and mortality.

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