Proficiency Testing in Clinical Toxicology: Program Sponsored by the Center for Disease Control

1977 ◽  
Vol 1 (3) ◽  
pp. 147-150 ◽  
Author(s):  
D. Joe Boone ◽  
G. O. Guerrant ◽  
R. W. Knouse
Keyword(s):  
Disease Control ◽  
Proficiency Testing ◽  
Clinical Toxicology

Results of the Center for Disease Control Proficiency Testing Program for the detection of hepatitis B surface antigen

1976 ◽  
Vol 4 (1) ◽  
pp. 32-39
Author(s):  
R N Taylor ◽  
K M Fulford
Keyword(s):  
Hepatitis B ◽  
Disease Control ◽  
Proficiency Testing ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Latex Agglutination ◽  
Lower Sensitivity ◽  
Passive Hemagglutination ◽  
Testing Program ◽  
Efficiency And Effectiveness

The changes in the types and numbers of tests used by participants in the Center for Disease Control Proficiency Testing Program for the detection of hepatitis B surface antigen from the beginning of the program in 1971 until October 1975 are analyzed; the implications of these changes are discussed. Changes in the use of agar gel diffusion, rheophoresis, counterelectrophoresis, complement fixation, reverse passive latex agglutination, radioimmunoassay, and reverse passive hemagglutination tests are reviewed. The performance of the participants for 1975 is reported, and factors related to performance (type or combinations of tests used, procedures used to confirm specificity, etc.) are discussed. The increase in the use of third-generation tests in place of tests with lower sensitivity and the decrease in the use of multiple tests undoubtedly represent increased efficiency and effectiveness.

Center for disease control diagnostic immunology proficiency testing program results for 1976

1977 ◽  
Vol 6 (3) ◽  
pp. 224-232
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
A Przybyszewski ◽  
V Pope
Keyword(s):  
Disease Control ◽  
Proficiency Testing ◽  
Hepatitis B Surface Antigen ◽  
Testing Program ◽  
Proficiency Levels ◽  
Clinical Laboratories ◽  
Individual Laboratory ◽  
Specific Proteins ◽  
Overall Performance ◽  
Testing Protocols

Over 900 laboratories participated in the Diagnostic Immunology portion of the 1976 Proficiency Testing Program, which was provided by the Center of Disease Control under the authority of the Clinical Laboratories Improvement Act of 1967. One hundred specimens prepared by the Center for Disease Control for analysis were distributed on a quarterly schedule or in special surveys. Feedback from participating laboratories included over 37,500 qualitative and 33,000 quantitative responses, which were analyzed to determine individual laboratory proficiency levels. In addition, information supplied by participants in each survey helped to delineate trends in testing protocols. The specimens chosen for analysis called for a broad range of tests commonly performed in diagnostic immunology laboratories, including those for rubella antibodies, hepatitis B surface antigen, bacterial antibodies, rheumatoid factor, immunoglobulins and other serum-specific proteins, and carcinoembryonic antigen. A summary of the data analysis is provided so that the laboratories can improve their overall performance levels.

1990 Medicare/CLIA final rules for proficiency testing: minimum intralaboratory performance characteristics (CV and bias) needed to pass

1990 ◽  
Vol 36 (10) ◽  
pp. 1736-1740 ◽  
Author(s):  
S S Ehrmeyer ◽  
R H Laessig ◽  
J E Leinweber ◽  
J J Oryall
Keyword(s):  
Health Care ◽  
Disease Control ◽  
Computer Modeling ◽  
Proficiency Testing ◽  
Health Care Financing ◽  
Performance Characteristics ◽  
Performance Criteria ◽  
Modeling Technique ◽  
Health Care Financing Administration ◽  
Minimum Performance

Abstract On March 14, 1990, the Centers for Disease Control and the Health Care Financing Administration published criteria for defining minimum performance in proficiency testing (PT). Using our previously described computer modeling technique, we determined the likelihood of passing PT under the new rules. The model relates combinations of intralaboratory CV and bias to PT performance criteria. For example, a laboratory with a bias of zero and an internal CV of 5% will pass a 10% fixed-limit PT criterion (i.e., the criterion for glucose analyses) 98% of the time when five samples are used. The model provides similar analyses for all PT criteria and all relevant combinations of CV and bias. The probability of passing PT decreases as the number of analytes tested increases, i.e., from 98% to 37% as the number of analytes increases from 1 to 20. A laboratory's internal CV has a greater effect on the outcome of PT than do the corresponding bias values. We conclude that a laboratory that operates with methods that have internal CVs less than or equal to 33% and biases less than or equal to 20% of the PT criteria will have a greater than 99% chance of passing PT.

scholarly journals A brief history of AAHL

2020 ◽  
Vol 41 (4) ◽  
pp. 210
Author(s):  
Paul Selleck
Keyword(s):  
Disease Control ◽  
Proficiency Testing ◽  
One Health ◽  
Animal Health ◽  
Reference Laboratory ◽  
International Reference ◽  
Animal Diseases ◽  
Diagnostic Facility ◽  
History Of ◽  
Exotic Animal

The CSIRO Australian Animal Health Laboratory (AAHL) was officially opened on 1 April 1985. After that day the laboratory switched to secure mode and has operated as such ever since. AAHL was constructed to be the primary national diagnostic facility for exotic animal diseases but has expanded its role to become a national and international reference laboratory for many diseases. AAHL has supported disease control within the region by providing training, reagents and proficiency testing, both within Australia and internationally. AAHL’s role has evolved even further to include a focus on one-health which resulted in AAHL being renamed the Australian Centre for Disease Preparedness (ACDP) in March 2020.

scholarly journals Center for Disease Control Diagnostic Immunology Proficiency Testing Program results for 1978.

1979 ◽  
Vol 10 (6) ◽  
pp. 805-814 ◽  
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
V A Przybyszewski ◽  
V Pope
Keyword(s):  
Disease Control ◽  
Proficiency Testing ◽  
Testing Program

scholarly journals Reduction of variation in results of rheumatoid factor tests by use of a serum reference preparation

1977 ◽  
Vol 5 (1) ◽  
pp. 42-45
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
W L Jones
Keyword(s):  
Disease Control ◽  
Rheumatoid Factor ◽  
Proficiency Testing ◽  
Test Results ◽  
Testing Program ◽  
Product Standardization ◽  
Reference Preparation ◽  
Reference Serum

Standaridizing test results for rheumatoid factor by comparing results obtained for an unknown with results obtained for a serum reference preparation decreased variance between laboratories, as measured in the Center for Disease Control proficiency testing program, by 77%. The amount of improvement was also estimated by the type of test and by the manufacturer's product. Standardization resulted in an increase in the number of reported results that were within a twofold dilution of the median value. The percentage increased from 50.3 to 93.7% for the slide tests and from 78.1 to 91.2% fro the tube tests. Decrease in variance by manufacturer's product ranged from 94 to 27%. The study demonstrated that adopting a reference serum standard could substantially improve the comparability of rheumatoid factor test results and that proficiency testing programs can be used to estimate improvement which could be expected as a result of standardization.

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