scholarly journals Center for Disease Control Diagnostic Immunology Proficiency Testing Program results for 1978.

1979 ◽  
Vol 10 (6) ◽  
pp. 805-814 ◽  
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
V A Przybyszewski ◽  
V Pope
Keyword(s):  
Disease Control ◽  
Proficiency Testing ◽  
Testing Program

Results of the Center for Disease Control Proficiency Testing Program for the detection of hepatitis B surface antigen

1976 ◽  
Vol 4 (1) ◽  
pp. 32-39
Author(s):  
R N Taylor ◽  
K M Fulford
Keyword(s):  
Hepatitis B ◽  
Disease Control ◽  
Proficiency Testing ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Latex Agglutination ◽  
Lower Sensitivity ◽  
Passive Hemagglutination ◽  
Testing Program ◽  
Efficiency And Effectiveness

The changes in the types and numbers of tests used by participants in the Center for Disease Control Proficiency Testing Program for the detection of hepatitis B surface antigen from the beginning of the program in 1971 until October 1975 are analyzed; the implications of these changes are discussed. Changes in the use of agar gel diffusion, rheophoresis, counterelectrophoresis, complement fixation, reverse passive latex agglutination, radioimmunoassay, and reverse passive hemagglutination tests are reviewed. The performance of the participants for 1975 is reported, and factors related to performance (type or combinations of tests used, procedures used to confirm specificity, etc.) are discussed. The increase in the use of third-generation tests in place of tests with lower sensitivity and the decrease in the use of multiple tests undoubtedly represent increased efficiency and effectiveness.

Center for disease control diagnostic immunology proficiency testing program results for 1976

1977 ◽  
Vol 6 (3) ◽  
pp. 224-232
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
A Przybyszewski ◽  
V Pope
Keyword(s):  
Disease Control ◽  
Proficiency Testing ◽  
Hepatitis B Surface Antigen ◽  
Testing Program ◽  
Proficiency Levels ◽  
Clinical Laboratories ◽  
Individual Laboratory ◽  
Specific Proteins ◽  
Overall Performance ◽  
Testing Protocols

Over 900 laboratories participated in the Diagnostic Immunology portion of the 1976 Proficiency Testing Program, which was provided by the Center of Disease Control under the authority of the Clinical Laboratories Improvement Act of 1967. One hundred specimens prepared by the Center for Disease Control for analysis were distributed on a quarterly schedule or in special surveys. Feedback from participating laboratories included over 37,500 qualitative and 33,000 quantitative responses, which were analyzed to determine individual laboratory proficiency levels. In addition, information supplied by participants in each survey helped to delineate trends in testing protocols. The specimens chosen for analysis called for a broad range of tests commonly performed in diagnostic immunology laboratories, including those for rubella antibodies, hepatitis B surface antigen, bacterial antibodies, rheumatoid factor, immunoglobulins and other serum-specific proteins, and carcinoembryonic antigen. A summary of the data analysis is provided so that the laboratories can improve their overall performance levels.

scholarly journals Reduction of variation in results of rheumatoid factor tests by use of a serum reference preparation

1977 ◽  
Vol 5 (1) ◽  
pp. 42-45
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
W L Jones
Keyword(s):  
Disease Control ◽  
Rheumatoid Factor ◽  
Proficiency Testing ◽  
Test Results ◽  
Testing Program ◽  
Product Standardization ◽  
Reference Preparation ◽  
Reference Serum

Standaridizing test results for rheumatoid factor by comparing results obtained for an unknown with results obtained for a serum reference preparation decreased variance between laboratories, as measured in the Center for Disease Control proficiency testing program, by 77%. The amount of improvement was also estimated by the type of test and by the manufacturer's product. Standardization resulted in an increase in the number of reported results that were within a twofold dilution of the median value. The percentage increased from 50.3 to 93.7% for the slide tests and from 78.1 to 91.2% fro the tube tests. Decrease in variance by manufacturer's product ranged from 94 to 27%. The study demonstrated that adopting a reference serum standard could substantially improve the comparability of rheumatoid factor test results and that proficiency testing programs can be used to estimate improvement which could be expected as a result of standardization.

Center for Disease Control Diagnostic Immunology Proficiency Testing Program results for 1977

1978 ◽  
Vol 8 (4) ◽  
pp. 388-395
Author(s):  
R N Taylor ◽  
K M Fulford ◽  
V A Przybyszewski ◽  
V Pope
Keyword(s):  
Hepatitis B ◽  
Disease Control ◽  
Rheumatoid Factor ◽  
Proficiency Testing ◽  
Hepatitis B Surface Antigen ◽  
Testing Program ◽  
Specific Proteins ◽  
Syphilis Serology ◽  
Testing Protocols ◽  
Yearly Data

A summary of the yearly data accumulated and analyzed in the diagnostic immunology portion of the Center for Disease Control 1977 Proficiency Testing Program provides information on the trends in testing protocols from over 900 participating laboratories. One hundred and fourteen specimens prepared by the Center for the Disease Control were distributed quarterly or in special surveys. The specimens chosen provided feedback from a broad range of tests commonly performed in diagnostic immunology laboratories and included those for rubella antibodies, hepatitis B surface antigen, bacterial antibodies, rheumatoid factor, immunoglobulins and other serum-specific proteins, syphilis serology, and carcinoembryonic antigen. This summary provides an overview of the trends observed since last year's report.

Variability in Testing for Antineutrophil Cytoplasmic Antibodies: A Survey of Participants in the College of American Pathologists Proficiency Testing Program

2016 ◽  
Vol 140 (6) ◽  
pp. 524-528
Author(s):  
William J. Karlon ◽  
Stanley J. Naides ◽  
John T. Crosson ◽  
Mohammad Qasim Ansari
Keyword(s):  
Proficiency Testing ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Testing Program ◽  
Acceptable Alternative ◽  
Disease States ◽  
Comprehensive Information ◽  
Testing Algorithms ◽  
Testing Practices ◽  
Current Guidelines ◽  
Multiplex Bead

Context.—Variability in testing for antineutrophil cytoplasmic antibodies (ANCAs) contributes to confusion and controversy related to testing for vasculitis and other ANCA-associated diseases. Objectives.—To survey laboratory testing practices regarding ANCA testing and to investigate differences in testing algorithms. Design.—Supplemental questions were sent to the 333 laboratories participating in the College of American Pathologists proficiency testing program for ANCA as part of the Special Immunology S2 Survey. Results.—A total of 315 laboratories submitted responses to the supplemental questions. Only 88 of 315 participants (28%) reported using a combination of indirect immunofluorescence (IFA) and enzyme immunoassay (EIA) techniques as recommended by current guidelines, with a few additional labs using IFA and multiplex bead assay as an acceptable alternative to EIA. Other labs reported using only IFA, EIA, or multiplex bead assays. Conclusions.—A wide variety of testing algorithms are in use for ANCA testing despite evidence to suggest that a combination of IFA and EIA testing provides the most comprehensive information. Laboratories should inform clinicians clearly about testing practices and utility of testing in specific disease states.

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