The Stability of Human Blood Lead in Storage

Composite chitosan fibers filled with chitin nanofibrils (CNF) were obtained by the wet spinning method. The paper discusses the mechanical properties of such type fibers and their hemocompatibility, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It was shown that low CNF concentration (about 0.5%) leads to an increase in fiber tensile strength due to the additional orientation of chitosan macromolecules. At the same time, with an increase in the content of CNF, the stability of the mechanical properties of composite fibers in a humid medium increases. All chitosan fibers, except 0.5% CNF, showed good hemocompatibility, even on prolonged contact with human blood. The addition of chitin nanofibers leads to decrease in hemoglobin molecules sorption due to the decline in optical density at wavelengths of 414 nm and 540 nm. Nevertheless, the hemolysis of fibers was comparable or even lesser that carbon hemosorbent, which is actively used in clinical practice.

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Reduced Albumin Binding Promotes the Stability and Activity of Topotecan in Human Blood

Biochemistry ◽

10.1021/bi00042a002 ◽

1995 ◽

Vol 34 (42) ◽

pp. 13722-13728 ◽

Cited By ~ 51

Author(s):

Zihou Mi ◽

Henryk Malak ◽

Thomas G. Burke

Keyword(s):

Human Blood ◽

Albumin Binding ◽

The Stability

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Transferability of blood lead determinations by furnace atomic absorption spectrophotometry and continuum background correction

Clinical Chemistry ◽

10.1093/clinchem/41.10.1451 ◽

1995 ◽

Vol 41 (10) ◽

pp. 1451-1454 ◽

Cited By ~ 7

Author(s):

H Qiao ◽

P J Parsons ◽

W Slavin

Keyword(s):

Detection Limit ◽

Atomic Absorption ◽

Reference Materials ◽

Human Blood ◽

Blood Lead ◽

Atomic Absorption Spectrophotometry ◽

Absorption Spectrophotometry ◽

Blood Specimens ◽

Blood Lead Determination ◽

The Continuum

Abstract We have examined and proved feasible the transfer of a method for blood lead determination, developed and optimized for a Zeeman-corrected instrument, to a continuum-corrected furnace atomic absorption spectrophotometer. Numerous reference materials analyzed with the continuum-corrected instrument gave results within 10 micrograms/L (0.05 mumol/L) at low values and varied by < 6% at values > 200 micrograms/L (0.97 mumol/L). Forty-four routine human blood specimens were analyzed by the same method with both continuum- and Zeeman-corrected instrumentation, and gave results that agreed within about the same limits as found with reference materials. The day-to-day precision was about 1/5 the accuracy results. The detection limit was approximately 5 micrograms/L (0.025 mumol/L).

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