scholarly journals A Consensus-based Guideline Defining the Clinical Target Volume for Pelvic Lymph Nodes in External Beam Radiotherapy for Uterine Cervical Cancer

2010 ◽  
Vol 40 (5) ◽  
pp. 456-463 ◽  
Author(s):  
T. Toita ◽  
T. Ohno ◽  
Y. Kaneyasu ◽  
T. Uno ◽  
R. Yoshimura ◽  
...  
2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17026-e17026
Author(s):  
Shun Lu

e17026 Background: A range of prognostic factors had been reported to be associated with clinical outcome of cervical cancer patients. However, most of these parameters were measured before the start of treatment but without consideration of tumor response to RT. We believed that it might be possible to provide locally advanced cervical cancer patients an opportunity to modify and guide the treatment strategies in the midway of treatment based on the early response evaluation during RT. To establish effective prognostic nomograms using clinical features including tumor volume and size mesured by MRI before treatment and after the completion of external beam radiotherapy (EBRT), and detailed dosimetry of brachytherapy dose for high-risk clinical target volume (HRCTV)D90 and Low-risk Clinical Target Volume(LR-CTV)D90. Methods: The nomogram for local control (LC) was based on a retrospective study of 316 patients who underwent IMRT at our hospital from 2010 to 2015. The predictive accuracy and discriminative ability of our nomogram models were determined by concordance index and calibration curve, and were compared with the nomogram models combining clinical features with FIGO stage. The results were validated using bootstrap resampling and a cohort study of 141 patients. The same data cohort was used to predict the progress-free survival (PFS) of cervical cancer with 3:1 training cohort (N = 310) and validation cohort (N = 155). Results: The following factors were assembled into our prognostic survival nomogram models: Age, tumor volume and size (TV & TS) before treatment, TV and TS after the completion of external beam radiotherapy (EBRT), brachytherapy dose of high-risk clinical target volume (HRCTV)D90 and Low-risk Clinical Target Volume(LR-CTV)D90. The calibration curves showed good agreement between nomogram-predicted and actual survival. Our nomogram models for LC and PFS, provided better results than the nomogram models combining clinical features with FIGO stage. Results were further confirmed in the validation set. Conclusions: Clinical features including tumor size and volume mesured before treatment and after EBRT, as well as detailed dosimetry of brachytherapy dose are able to improve the performance of prognostic nomograms for patients with cervical cancer.


Author(s):  
Judit A. Adam ◽  
Hester Arkies ◽  
Karel Hinnen ◽  
Lukas J. Stalpers ◽  
Jan H. van Waesberghe ◽  
...  

Author(s):  
Judit A. Adam ◽  
Annika Loft ◽  
Cyrus Chargari ◽  
Roberto C. Delgado Bolton ◽  
Elisabeth Kidd ◽  
...  

Abstract Purpose The aim of this EANM / SNMMI Practice Guideline with ESTRO endorsement is to provide general information and specific considerations about [18F]FDG PET/CT in advanced uterine cervical cancer for external beam radiotherapy planning with emphasis on staging and target definition, mostly in FIGO stages IB3-IVA and IVB, treated with curative intention. Methods Guidelines from related fields, relevant literature and leading experts have been consulted during the development of this guideline. As this field is rapidly evolving, this guideline cannot be seen as definitive, nor is it a summary of all existing protocols. Local variations should be taken into consideration when applying this guideline. Conclusion The background, common clinical indications, qualifications and responsibilities of personnel, procedure / specifications of the examination, documentation / reporting and equipment specifications, quality control and radiation safety in imaging is discussed with an emphasis on the multidisciplinary approach.


2016 ◽  
Vol 6 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Naoya Murakami ◽  
Yoshiki Norihisa ◽  
Fumiaki Isohashi ◽  
Keiko Murofushi ◽  
Takuro Ariga ◽  
...  

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Goro Kasuya ◽  
Takafumi Toita ◽  
Kazuhisa Furutani ◽  
Takeshi Kodaira ◽  
Tatsuya Ohno ◽  
...  

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