Dietary Zinc Alters Early Inflammatory Responses during Cutaneous Wound Healing in Weanling CD-1 Mice

Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.

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miR-23b promotes cutaneous wound healing through inhibition of the inflammatory responses by targeting ASK1

Acta Biochimica et Biophysica Sinica ◽

10.1093/abbs/gmy109 ◽

2018 ◽

Cited By ~ 3

Author(s):

Hongzhi Li ◽

Xiao Han ◽

Kuiyang Zuo ◽

Li Li ◽

Jieting Liu ◽

...

Keyword(s):

Wound Healing ◽

Inflammatory Responses ◽

Cutaneous Wound Healing ◽

Cutaneous Wound

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Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury

Toxicological Sciences ◽

10.1093/toxsci/kfx137 ◽

2017 ◽

Vol 159 (2) ◽

pp. 327-338 ◽

Cited By ~ 8

Author(s):

Hong Mei ◽

Pengle Yao ◽

Shanshan Wang ◽

Na Li ◽

Tengfei Zhu ◽

...

Keyword(s):

Wound Healing ◽

Low Dose ◽

Inflammatory Responses ◽

Cadmium Exposure ◽

Cutaneous Wound Healing ◽

Skin Injury ◽

Cutaneous Wound

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Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2017/8950516 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Xiao-wen Jiang ◽

Lu Qiao ◽

Lin Liu ◽

Bin-qing Zhang ◽

Xue-wei Wang ◽

...

Keyword(s):

Wound Healing ◽

Wistar Rats ◽

Inflammatory Responses ◽

Tissue Growth ◽

Control Treatment ◽

Cutaneous Wound Healing ◽

Cutaneous Wound ◽

Dragon’S Blood ◽

Biochemical Analyses ◽

Dracorhodin Perchlorate

Dracorhodin perchlorate (DP) is extracted from Dragon’s blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-α and IL-β and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing.

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