scholarly journals Dietary Supplementation of Genistein Attenuates Inflammatory Responses and Oxidative Stress during Cutaneous Wound Healing in Diabetic Mice

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Hyeyoon Eo ◽  
Ji-Young Ann ◽  
Yunsook Lim
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Inflammatory Responses ◽  
Dietary Supplementation ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Cutaneous Wound ◽  
And Oxidative Stress

scholarly journals Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Na-Young Park ◽  
Giuseppe Valacchi ◽  
Yunsook Lim
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Wound Closure ◽  
Inflammatory Responses ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory

Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.

scholarly journals Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4210
Author(s):  
Yan Zhou ◽  
Chunxiu Zhou ◽  
Xutao Zhang ◽  
Chi Teng Vong ◽  
Yitao Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Vascular Function ◽  
Inflammatory Responses ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Diabetic Mice ◽  
And Oxidative Stress

Coptisine is the major bioactive protoberberine alkaloid found in Rhizoma Coptidis. Coptisine reduces inflammatory responses and improves glucose tolerance; nevertheless, whether coptisine has vasoprotective effect in diabetes is not fully characterized. Conduit arteries including aortas and carotid arteries were obtained from male C57BL/6J mice for ex vivo treatment with risk factors (high glucose or tunicamycin) and coptisine. Some arterial rings were obtained from diabetic mice, which were induced by high-fat diet (45% kcal% fat) feeding for 6 weeks combined with a low-dose intraperitoneal injection of streptozotocin (120 mg/kg). Functional studies showed that coptisine protected endothelium-dependent relaxation in aortas against risk factors and from diabetic mice. Coptisine increased phosphorylations of AMPK and eNOS and downregulated the endoplasmic reticulum (ER) stress markers as determined by Western blotting. Coptisine elevates NO bioavailability and decreases reactive oxygen species level. The results indicate that coptisine improves vascular function in diabetes through suppression of ER stress and oxidative stress, implying the therapeutic potential of coptisine to treat diabetic vasculopathy.

scholarly journals Comparison of EGF with VEGF Non-Viral Gene Therapy for Cutaneous Wound Healing of Streptozotocin Diabetic Mice

2011 ◽  
Vol 35 (3) ◽  
pp. 226 ◽  
Author(s):  
Junghae Ko ◽  
Haejung Jun ◽  
Hyesook Chung ◽  
Changshin Yoon ◽  
Taekyoon Kim ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Wound Healing ◽  
Viral Gene ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Cutaneous Wound ◽  
Viral Gene Therapy

scholarly journals The effects of topical melatonin on oxidative stress, apoptosis signals,and p53 protein expression during cutaneous wound healing

2015 ◽  
Vol 39 ◽  
pp. 888-895 ◽  
Author(s):  
Azize ŞENER ◽  
Özge ÇEVİK ◽  
Özge DOĞAN ◽  
Nazlı Gül ALTINDİŞ ◽  
Halil AKSOY ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Protein Expression ◽  
P53 Protein ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
P53 Protein Expression

scholarly journals Cutaneous Wound Healing in Diabetic Mice Is Improved by Topical Mineralocorticoid Receptor Blockade

2020 ◽  
Vol 140 (1) ◽  
pp. 223-234.e7 ◽  
Author(s):  
Van Tuan Nguyen ◽  
Nicolette Farman ◽  
Roberto Palacios-Ramirez ◽  
Maria Sbeih ◽  
Francine Behar-Cohen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mineralocorticoid Receptor ◽  
Receptor Blockade ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Cutaneous Wound ◽  
Mineralocorticoid Receptor Blockade
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