scholarly journals Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury

2017 ◽  
Vol 159 (2) ◽  
pp. 327-338 ◽  
Author(s):  
Hong Mei ◽  
Pengle Yao ◽  
Shanshan Wang ◽  
Na Li ◽  
Tengfei Zhu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Low Dose ◽  
Inflammatory Responses ◽  
Cadmium Exposure ◽  
Cutaneous Wound Healing ◽  
Skin Injury ◽  
Cutaneous Wound

scholarly journals Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Na-Young Park ◽  
Giuseppe Valacchi ◽  
Yunsook Lim
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Wound Closure ◽  
Inflammatory Responses ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory

Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.

Low-Dose Propranolol Improves Cutaneous Wound Healing of Burn-Injured Rats

2008 ◽  
Vol 122 (6) ◽  
pp. 1690-1699 ◽  
Author(s):  
Bruna Romana-Souza ◽  
Adriana P. Nascimento ◽  
Andréa Monte-Alto-Costa
Keyword(s):  
Wound Healing ◽  
Low Dose ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Xiao-wen Jiang ◽  
Lu Qiao ◽  
Lin Liu ◽  
Bin-qing Zhang ◽  
Xue-wei Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Inflammatory Responses ◽  
Tissue Growth ◽  
Control Treatment ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Dragon’S Blood ◽  
Biochemical Analyses ◽  
Dracorhodin Perchlorate

Dracorhodin perchlorate (DP) is extracted from Dragon’s blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-α and IL-β and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing.

scholarly journals Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats

2011 ◽  
Vol 10 (1) ◽  
pp. 235 ◽  
Author(s):  
Hossam Ebaid ◽  
Amir Salem ◽  
Abdalla Sayed ◽  
Ali Metwalli
Keyword(s):  
Wound Healing ◽  
Whey Protein ◽  
Inflammatory Responses ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

IGF-1C domain-modified chitosan hydrogel accelerates cutaneous wound healing by promoting angiogenesis

2020 ◽  
Author(s):  
Qiong Li ◽  
Jian Cui ◽  
Haoyan Huang ◽  
Zhiwei Yue ◽  
Yuqiao Chang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Remodeling ◽  
Cutaneous Wound Healing ◽  
Skin Injury ◽  
Chitosan Hydrogel ◽  
Cutaneous Wound ◽  
Modified Chitosan ◽  
Complete Regeneration ◽  
Mimicking Peptides

Background: Complete regeneration after skin injury remains a critical clinical challenge. Hydrogels, modified with growth factors or mimicking peptides, have been applied for functional tissue regeneration by increasing the bioactivity of engineered matrices. Methodology & results: We synthesized an injectable biological hydrogel, C domain of IGF-1 (IGF-1C)-modified chitosan (CS–IGF-1C) hydrogel. Mouse model of cutaneous wound healing was established to investigate whether this hydrogel could promote wound healing. Our results demonstrated that CS–IGF-1C hydrogel exhibited superior proangiogenic effects, resulting in accelerated wound closure and improved extracellular matrix remodeling. Bioluminescence imaging and histology analysis confirmed the proangiogenic role of CS–IGF-1C hydrogel. Conclusion: CS–IGF-1C hydrogel could accelerate cutaneous wound healing by stimulating angiogenesis.

scholarly journals Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

2017 ◽  
Vol 32 (9) ◽  
pp. 726-735 ◽  
Author(s):  
Lígia Reis Moura Estevão ◽  
Ricardo Santos Simões ◽  
Puebla Cassini-Vieira ◽  
Maria Cecilia Campos Canesso ◽  
Lucíola da Silva Barcelos ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Responses ◽  
Cutaneous Wound Healing ◽  
Schinus Terebinthifolius ◽  
Cutaneous Wound
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