scholarly journals Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Na-Young Park ◽  
Giuseppe Valacchi ◽  
Yunsook Lim
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Wound Closure ◽  
Inflammatory Responses ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory

Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous wound healing as a result of modulating oxidative stress and inflammatory responses.

scholarly journals Stellera chamaejasme and its constituents induce cutaneous wound healing and anti-inflammatory activities

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Myungsuk Kim ◽  
Hee Ju Lee ◽  
Ahmad Randy ◽  
Ji Ho Yun ◽  
Sang-Rok Oh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory ◽  
Stellera Chamaejasme

scholarly journals Gypenoside LXXV Promotes Cutaneous Wound Healing In Vivo by Enhancing Connective Tissue Growth Factor Levels Via the Glucocorticoid Receptor Pathway

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1595 ◽  
Author(s):  
Sungjoo Park ◽  
Eunsu Ko ◽  
Jun Hyoung Lee ◽  
Yoseb Song ◽  
Chang-Hao Cui ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Connective Tissue ◽  
Wound Closure ◽  
Tissue Growth ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
And Migration ◽  
Proliferation And Migration

Cutaneous wound healing is a well-orchestrated event in which many types of cells and growth factors are involved in restoring the barrier function of skin. In order to identify whether ginsenosides, the main active components of Panax ginseng, promote wound healing, the proliferation and migration activities of 15 different ginsenosides were tested by MTT assay and scratched wound closure assay. Among ginsenosides, gypenoside LXXV (G75) showed the most potent wound healing effects. Thus, this study aimed to investigate the effects of G75 on wound healing in vivo and characterize associated molecular changes. G75 significantly increased proliferation and migration of keratinocytes and fibroblasts, and promoted wound closure in an excision wound mouse model compared with madecassoside (MA), which has been used to treat wounds. Additionally, RNA sequencing data revealed G75-mediated significant upregulation of connective tissue growth factor (CTGF), which is known to be produced via the glucocorticoid receptor (GR) pathway. Consistently, the increase in production of CTGF was confirmed by western blot and ELISA. In addition, GR-competitive binding assay and GR translocation assay results demonstrated that G75 can be bound to GR and translocated into the nucleus. These results demonstrated that G75 is a newly identified effective component in wound healing.

Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats

2014 ◽  
Vol 20 (2) ◽  
pp. 322-330 ◽  
Author(s):  
Vinay Kant ◽  
Anu Gopal ◽  
Nitya N. Pathak ◽  
Pawan Kumar ◽  
Surendra K. Tandan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory

scholarly journals Temporal Effects of Topical Morphine Application on Cutaneous Wound Healing

2008 ◽  
Vol 109 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Jerri M. Rook ◽  
Wohaib Hasan ◽  
Kenneth E. McCarson
Keyword(s):  
Wound Healing ◽  
Time Course ◽  
Wound Closure ◽  
Healing Process ◽  
Topical Administration ◽  
Scar Tissue ◽  
Skin Thickness ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Opioid Administration

Background Studies have shown that topical administration of exogenous opioid drugs impairs wound healing by inhibiting the peripheral release of neuropeptides, thereby inhibiting neurogenic inflammation. This delay is immediate and peaks during the first days of wound closure. This study examined the effects of topical morphine treatment in a cutaneous wound healing model in the rat. Methods Full-thickness 4-mm-diameter wounds were placed on the periscapular region of rats that subsequently received twice-daily topical applications of IntraSite Gel (Smith+Nephew, Hull, United Kingdom) alone or gel infused with 5 mm morphine sulfate on days 0-3 or 4-10 postwounding or throughout the time course. Wound tissue was taken on days 1, 3, 5, 8, and 18 postwounding and immunostained for myofibroblast and macrophage markers or stained with hematoxylin and eosin. Results Delays in wound closure observed during morphine application on days 0-3 postwounding mimicked those seen in wounds treated with morphine throughout the entire healing process. However, no significant delays in closure were seen in wounds treated with morphine beginning on day 4 postwounding. Treatment of wounds with morphine significantly reduced the number of myofibroblasts and macrophages in the closing wound. In addition, morphine application resulted in decreases in skin thickness and an increase in residual scar tissue in healed skin. Conclusions These findings demonstrate the time-dependent and persistent nature of the detrimental effects of topical morphine on cutaneous wound healing. The data identify specific limitations that could be ameliorated to optimize topical opioid administration as an analgesic therapeutic strategy in the treatment of painful cutaneous wounds.

scholarly journals The effects of topical melatonin on oxidative stress, apoptosis signals,and p53 protein expression during cutaneous wound healing

2015 ◽  
Vol 39 ◽  
pp. 888-895 ◽  
Author(s):  
Azize ŞENER ◽  
Özge ÇEVİK ◽  
Özge DOĞAN ◽  
Nazlı Gül ALTINDİŞ ◽  
Halil AKSOY ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Protein Expression ◽  
P53 Protein ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
P53 Protein Expression

Anti-inflammatory and antioxidant properties of Alternanthera brasiliana improve cutaneous wound healing in rats

2021 ◽  
Vol 29 (5) ◽  
pp. 1443-1458
Author(s):  
Rogério Marchete ◽  
Sarah Oliveira ◽  
Leonardo Bagne ◽  
Jennyffer Ione de Souza Silva ◽  
Ana Paula Valverde ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antioxidant Properties ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Anti Inflammatory

scholarly journals Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Li Hu ◽  
Juan Wang ◽  
Xin Zhou ◽  
Zehuan Xiong ◽  
Jiajia Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Early Stage ◽  
Mouse Skin ◽  
Scar Formation ◽  
Collagen I ◽  
Dependent Manner ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Abstract Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we investigated the roles of ASCs-derived exosomes (ASCs-Exos) in cutaneous wound healing. We found that ASCs-Exos could be taken up and internalized by fibroblasts to stimulate cell migration, proliferation and collagen synthesis in a dose-dependent manner, with increased genes expression of N-cadherin, cyclin-1, PCNA and collagen I, III. In vivo tracing experiments demonstrated that ASCs-Exos can be recruited to soft tissue wound area in a mouse skin incision model and significantly accelerated cutaneous wound healing. Histological analysis showed increased collagen I and III production by systemic administration of exosomes in the early stage of wound healing, while in the late stage, exosomes might inhibit collagen expression to reduce scar formation. Collectively, our findings indicate that ASCs-Exos can facilitate cutaneous wound healing via optimizing the characteristics of fibroblasts. Our results provide a new perspective and therapeutic strategy for the use of ASCs-Exos in soft tissue repair.

Laser phototherapy improves early stage of cutaneous wound healing of rats under hyperlipidic diet

2016 ◽  
Vol 31 (7) ◽  
pp. 1363-1370 ◽  
Author(s):  
Virgínia Dias Uzêda-e-Silva ◽  
Tania Tavares Rodriguez ◽  
Isadora Almeida Rios Rocha ◽  
Flávia Calo Aquino Xavier ◽  
Jean Nunes dos Santos ◽  
...  
Keyword(s):  
Wound Healing ◽  
Early Stage ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Laser Phototherapy ◽  
Hyperlipidic Diet
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