Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas

1990 ◽  
Vol 82 (16) ◽  
pp. 1333-1339 ◽  
Author(s):  
T. L. McLemore ◽  
S. Adelberg ◽  
M. C. Liu ◽  
N. A. McMahon ◽  
S. J. Yu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Gene Regulation ◽  
Cigarette Smoke ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Cyp1a1 Gene ◽  
Altered Gene

AbnormalFHIT transcripts found in both lung cancer and normal lung tissue

1999 ◽  
Vol 24 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Yoshio Tokuchi ◽  
Yasuhito Kobayashi ◽  
Shin-ichi Hayashi ◽  
Moriaki Hayashi ◽  
Keiji Tanimoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung

Micro-RNA signature differences in lung adenocarcinoma with specific driver alterations.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 11066-11066
Author(s):  
Lorenza Landi ◽  
Pierluigi Gasparini ◽  
Stefania Carasi ◽  
Carmelo Tibaldi ◽  
Luciano Cascione ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Lung Tissue ◽  
Kras Mutation ◽  
Triple Negative ◽  
Egfr Mutation ◽  
Differential Expression Analysis ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Expression Levels

11066 Background: Oncogenic driving alterations define types of lung adenocarcinoma with different prognosis and sensitivity to targeted agents. MicroRNAs (miRNAs) are a new class of non-coding RNAs involved in gene expression regulation. How miRNAs are dysregulated in lung cancer with ALK translocation, EGFR or KRAS mutation is unknown. In this study we aimed to identify miRNA signatures according to the presence of specific driver and to correlate miRNAs deregulation with patient outcome. Methods: The study was conducted in a cohort of 70 lung cancer patients (pts) including 18 ALK+ tumors, 11 ALK-/EGFR mutation+, 15 ALK-/KRAS mutation+, 26 ALK-/EGFR and KRAS wild-type and defined as triple negative. Matched normal lung tissue from 18 cases representative of the entire cohort were also included onto the analysis. RNA was isolated from formalin-fixed paraffin-embedded tissue (FFPE), using the Recover ALL kit (Ambion). NanoString nCounter system platform was used to generate the miRNA profile. We used Limma to test for differential expression analysis of data. The miR-515 family expression between tissues was validated by RT-qPCRs, analyzed using the parametric t-test (unpaired, 2-tailed for validation). Results: miRNA expression profile clusters distinctly ALK+ pts from ALK- and normal lung tissue. Within the ALK- group we found specific miRNAs subsets able to sub-stratify KRAS versus EGFR careers clustering sharply triple negative versus EGFR mutation+ and triple negative versus KRAS mutation+. miRNAs belonging to the miR-515 family seems to be the most deregulated in the ALK+ versus ALK-. Although their expression is stably high in normal tissues and ALK+ class, they are highly downregulated in KRAS mutated versus EGFR mutated and versus triple negative (p-value <0.001 for all comparisons). Conclusions: miRNAs profile significantly differs in pts with ALK translocation, EGFR mutations and KRAS mutations. Analysis of miR-515 family members is ongoing in order to correlate their expression levels with pts’ outcome. In vitro modulation of miR-515 family expression levels, together with drugs treatment are ongoing in order to find possible chemo-resistance/chemo-sensitivity miRNA dependent, in ALK+ and ALK- model.

scholarly journals Prediction of the gene expression in normal lung tissue by the gene expression in blood

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Justin W. Halloran ◽  
Dakai Zhu ◽  
David C. Qian ◽  
Jinyoung Byun ◽  
Olga Y. Gorlova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung

Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma

Lung Cancer ◽  
2008 ◽  
Vol 62 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Eugene P. Kopantzev ◽  
Galina S. Monastyrskaya ◽  
Tatyana V. Vinogradova ◽  
Marina V. Zinovyeva ◽  
Marya B. Kostina ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Carcinoma ◽  
Lung Tissue ◽  
Lung Development ◽  
Human Lung ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Expression Levels ◽  
Gene Expression Levels

scholarly journals OC-0375 Improving lung cancer outcome by reducing normal lung tissue toxicity

2019 ◽  
Vol 133 ◽  
pp. S186-S187
Author(s):  
L. Giuranno ◽  
E. Roig Moreno ◽  
R. Iannone ◽  
M. Vooijs
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Cancer Outcome

scholarly journals P1.02-009 Accumulation of Mutations in Background Normal Lung Tissue Constitutes a Major Lung Cancer Risk

2017 ◽  
Vol 12 (11) ◽  
pp. S1927-S1928
Author(s):  
E. Kubo ◽  
H. Takeshima ◽  
S. Yamashita ◽  
N. Motoi ◽  
T. Ushijima
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Lung Tissue ◽  
Lung Cancer Risk ◽  
Normal Lung Tissue ◽  
Normal Lung

Expression of BCRP gene in the normal lung tissue and lung cancer

2001 ◽  
Vol 13 (1) ◽  
pp. 22-26
Author(s):  
You-sheng Mao ◽  
Austin Doyle ◽  
Weidong Yang ◽  
Yuetong Wei ◽  
Mark J. Krasna ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Normal Lung Tissue ◽  
Normal Lung

scholarly journals Immunofluorescent analyses of tumor marker beta-III tubuilin expression in tumor and ajacent normal lung tissue derived from patients with non-small cell lung cancer

2016 ◽  
Vol 15 (2) ◽  
pp. 16-18 ◽  
Author(s):  
I. A. Mamichev ◽  
T. A. Bogush ◽  
E. A. Dudko ◽  
O. M. Ryabinina ◽  
A. N. Grishanina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Lung Tissue ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Normal Lung Tissue ◽  
Normal Lung ◽  
Small Cell Lung ◽  
Biopsy Specimens ◽  
Tissue Specimens

Background. Class III beta-tubulin (TUBB3) is one of the eight beta tubulin isotypes identified in human. It is constitutively expressed in brain and testis but not in lung tissue. TUBB3 is also known to appear in solid tumors, in particular in non-small cell lung cancer (NSCLC), and it is often associated with poor prognosis and resistance to taxanes and Vinka alkaloids. Objective: We have suggested that TUBB3 expression may cover not only the primary tumor but also a wide adjacent area of morphologically normal lung tissue. To check the hypothesis we have measured TUBB3 expression both in the non-small cell lung carcinoma (NSCLC) and remote lung tissue derived from the same lung. 60surgical biopsy specimens of NSCLC and morphologically normal lung tissue of 30patients were investigated. Materials and methods. Biopsy specimens were converted to suspension, fixed in 4 % formaldehyde and analyzed by flow cytometry using monoclonal antibodies to TUBB3. The method was developed in the laboratory of medicinal chemistry research Institute of experimental diagnostics and therapy of tumors (N.N. Blokhin Russian Cancer Research Center) and patented. Results. Fraction of TUBB3-positive cells in the group of adjacent lung tissue specimens was lower compared to NSCLC group but still positive in the majority of adjacent lung tissue specimens (25 of 30) and achieved up to 39 % of cells. Conclusion. We suggest that TUBB3 expression in adjacent morphologically normal lung tissue indicates presence of transformed and potentially malignant cells far from the primary site.

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