Adult Hippocampal Neurogenesis, Pattern Separation, and Generalization

2016 ◽  
Author(s):  
Kristen C. Klemenhagen ◽  
Franklin R. Schneier ◽  
Abby J. Fyer ◽  
H. Blair Simpson ◽  
René Hen
Keyword(s):  
Anxiety Disorder ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Pattern Separation ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Evidence Based Treatments ◽  
Post Traumatic ◽  
Pathological Anxiety

Almost one-third of adult Americans will have an anxiety disorder in their lifetime, with enormous personal, societal, and financial costs. Among the most disabling of these disorders are post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), social anxiety disorder, generalized anxiety disorder, and panic disorder. Although there are evidence-based treatments for these disorders, as many as 50% of patients do not respond, and there is a considerable need for new therapies. This chapter proposes that the excessive generalization seen in patients with pathological anxiety is due to impaired hippocampal functioning, specifically a deficit in the neural process of pattern separation, which relies upon the dentate gyrus and is sensitive to neurogenesis. Preclinical findings indicate that stimulating DG neurogenesis improves pattern separation and reduces anxiety behaviors in mice. As a result the authors hypothesize that pharmacological or environmental manipulations aimed at stimulating neurogenesis will be beneficial for the treatment of anxiety disorders.

TMS in the study and treatment of anxiety disorders

2012 ◽  
Author(s):  
Benjamin Greenberg ◽  
Sarah H. Lisanby
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Therapeutic Effects ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Systematic Testing ◽  
Compulsive Disorder ◽  
Current State ◽  
Post Traumatic ◽  
Disorder Treatment

A few studies of transcranial magnetic stimulation (TMS) as an anxiety disorder treatment have been reported. In treatment studies, the focal application of TMS in the treatment of anxiety disorders has been guided by the present understanding of the neurocircuitry underlying these disorders. This article reviews the current state of the literature on the uses of TMS in the study and treatment of anxiety disorders, and discusses the implications for understanding their patho-etiology. Investigation of the possible therapeutic effects of repetitive TMS in obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), or any anxiety disorder remains at a preliminary stage. There have been promising initial observations in OCD, which require systematic testing in controlled studies. As far as PTSD is concerned, the available data suggest that additional TMS work is required. The observations need to be replicated in controlled settings to determine whether this approach will have value in treating anxiety disorders.

Ketamine’s dose-related effects on anxiety symptoms in patients with treatment refractory anxiety disorders

2017 ◽  
Vol 31 (10) ◽  
pp. 1302-1305 ◽  
Author(s):  
Paul Glue ◽  
Natalie J Medlicott ◽  
Sarah Harland ◽  
Shona Neehoff ◽  
Bridie Anderson-Fahey ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Post Traumatic Stress ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Post Traumatic ◽  
Resistant Depression

The N-methyl-D-aspartate receptor antagonist ketamine has rapid onset activity in treatment-resistant depression, post-traumatic stress disorder and obsessive compulsive disorder. Due to similarities in brain network activity in depression and anxiety disorders, we hypothesized that ketamine might also be active in other refractory anxiety disorders. We evaluated the efficacy and safety of ketamine in 12 patients with refractory generalized anxiety disorder and/or social anxiety disorder who were not currently depressed, using an ascending single dose study design (0.25, 0.5, 1 mg/kg administered subcutaneously) at weekly intervals. Within 1 h of dosing, patients reported reduced anxiety, which persisted for up to seven days. A dose-response profile was noted for anxiolytic effects, dissociative side effects, and changes in blood pressure and heart rate, with minor changes at 0.25 mg/kg, and progressively greater and more durable changes at the higher doses. Ten of 12 patients were treatment responders at 0.5–1 mg/kg. Ketamine was safe and well tolerated in this population. Ketamine may be a potential therapeutic alternative for patients with refractory generalized anxiety disorder/social anxiety disorder. Along with its demonstrated effectiveness in patients with treatment-resistant depression, obsessive compulsive disorder and post-traumatic stress disorder, these data raise the intriguing possibility that ketamine may have broad efficacy in disorders characterized by negative emotional states, and that these disorders may share a common precipitating neurobiology.

Anxiety and Related Disorders in People with Intellectual Disability

2020 ◽  
pp. 129-140
Author(s):  
Sherva Cooray ◽  
Avinash Hiremath
Keyword(s):  
Anxiety Disorder ◽  
Separation Anxiety ◽  
Separation Anxiety Disorder ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Cognitive Limitations ◽  
Treatment Models ◽  
Post Traumatic ◽  
People With Intellectual Disabilities

This chapter provides an overview of anxiety and related disorders including, generalized anxiety disorder, panic disorder, agoraphobia, specific phobia, social anxiety disorder, separation anxiety disorder, hypochondriasis, obsessive compulsive disorder (OCD) and post traumatic stress disorder (PTSD). It covers the diagnosis, clinical features, epidemiology, aetiology, pathophysiology, risk factors, treatment, and prognosis. Due to the cognitive limitations and needs profile of people with intellectual disabilities (ID), the diagnosis of these conditions is particularly challenging, due to which they are under-recognized and poorly treated. The approaches to management are largely modelled on treatment models used in the mainstream populations without ID, although these models have to be adapted appropriately to the needs of the individual’s psychological, biological, and social circumstances.

Anxiety and stress-related disorders

2019 ◽  
pp. 361-408
Author(s):  
David Semple ◽  
Roger Smyth
Keyword(s):  
Anxiety Disorder ◽  
Panic Disorder ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Hyperventilation Syndrome ◽  
Management Guidelines ◽  
Compulsive Disorder ◽  
Post Traumatic

This chapter covers the anxiety and stress-related disorders. Associated disorders, including panic disorder, generalized anxiety disorder, hyperventilation syndrome, obsessive–compulsive disorder, phobias, and post-traumatic stress disorder (PTSD) are covered. Each has its clinical features described and diagnostic requirements defined. Management guidelines are presented for each case, and any controversies in the field are outlined.

scholarly journals Likely Exacerbation of Psychological Disorders from Covid-19 Response

2021 ◽  
Vol 12 ◽  
pp. 215013272110167
Author(s):  
Tara Rava Zolnikov ◽  
Tanya Clark ◽  
Tessa Zolnikov
Keyword(s):  
Psychological Disorders ◽  
Emotional Reactions ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Current State ◽  
The Face ◽  
Adults And Children ◽  
Post Traumatic ◽  
Anxiety Depression

Anxiety and fear felt by people around the world regarding the coronavirus pandemic is real and can be overwhelming, resulting in strong emotional reactions in adults and children. With depressive and anxiety disorders already highly prevalent in the general population (300 million worldwide), depression and/or anxiety specifically because of the pandemic response is likely. Moreover, the current state of panic in the face of uncertainty is apt to produce significant amounts of stress. While this situation has the potential to cause psychological disorders in previously unaffected populations, perhaps more impactful is the exacerbation of symptoms of many existing disorders including anxiety, depression, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD) and hoarding disorder.

How Microaggressions Are Harmful

2020 ◽  
pp. 43-56
Author(s):  
Monnica T. Williams
Keyword(s):  
Mental Health ◽  
Negative Impact ◽  
Somatic Symptoms ◽  
Mental Health Issue ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Implicit Biases ◽  
Post Traumatic ◽  
Everyday Discrimination

Abstract: This chapter discusses the research regarding microaggressions and negative mental health outcomes. Microaggressions are associated with increased stress, increased physical ailments such as hypertension and impaired immune responses, increased depression and depressive symptoms, lower self-esteem and self-efficacy, increased alcohol abuse and binge drinking, substance use disorders, increased post-traumatic stress disorder symptoms, higher levels of suicidal ideation, increased anxiety, increased somatic symptoms and negative affect, and increased obsessive–compulsive disorder symptoms. Overall, those who experience everyday discrimination have higher odds of any lifetime mental health issue. This is illustrated using a case example of a student who developed depression and anxiety from experiencing microaggressions in school, leading to a negative impact on mental health. The chapter presents an example interaction between a client and a therapist illustrating that microaggressions can be harmful to White people as well in indirect ways. Furthermore, to address mental health disparities and treatment barriers as a result of various pathways including microaggressions, clinicians need to address their own possible implicit biases that can lead to perpetuating these problems.

Which biopsychosocial view of mental illness?

2020 ◽  
pp. 82-96
Author(s):  
Walter Sinnott-Armstrong ◽  
Jesse S. Summers
Keyword(s):  
Mental Illness ◽  
Social Engagement ◽  
Psychological Symptoms ◽  
Mental Illnesses ◽  
Post Traumatic Stress ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Disinhibited Social Engagement Disorder ◽  
Post Traumatic ◽  
Almost All

Biopsychosocial theories of mental illness claim that biological, psychological, and social factors are all central to every mental illness. This general approach cannot be assessed or employed properly without specifying the precise relation between mental illnesses and these three levels of understanding. This chapter distinguishes disjunctive, causal, explanatory, therapeutic (or treatment), and constitutive (or definitional) versions of biopsychosocial theories. However, all of these claims are uncontroversial and not distinctive of the biopsychosocial approach, except the constitutive claim. That constitutive claim is inaccurate, because almost all mental illnesses are and should be defined by their psychological symptoms instead of their biological or social causes. These lessons are applied to case studies of post-traumatic stress disorder, disinhibited social engagement disorder, obsessive–compulsive disorder, and scrupulosity.

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