Metabolic Therapy and Pain

2016 ◽  
Author(s):  
David N. Ruskin
Keyword(s):  
Chronic Pain ◽  
Pain Syndrome ◽  
Poor Quality ◽  
Fatty Acid Supplementation ◽  
Pain Syndromes ◽  
Drug Treatments ◽  
Dietary Treatments ◽  
Dietary Modifications ◽  
Chronic Pain Syndromes

Chronic pain is associated strongly with poor quality of life. Drug treatments for pain can be problematic; with the understanding that chronic pain syndromes often involve derangement of homeostasis, there is an increased interest in applying nonpharmacological metabolic therapies. This chapter surveys clinical and animal research into the effects of fasting, calorie restriction, ketogenic diet, and polyunsaturated fatty acid supplementation on pain. These dietary treatments can significantly ameliorate pain in inflammatory and neuropathic disorders. The choice among these treatments might depend on the specific pain syndrome and the tolerance of the patient for particular dietary modifications. Several possible mechanisms are discussed, some of which might be in common among these treatments, and some treatments might engage multiple mechanisms. Multiple mechanisms acting together could be ideal for restoring the disordered metabolism underlying some pain syndromes.

Chronic pain syndromes

2018 ◽  
pp. 623-642
Author(s):  
Gavin Clunie ◽  
Nick Wilkinson ◽  
Elena Nikiphorou ◽  
Deepak R. Jadon
Keyword(s):  
Chronic Pain ◽  
General Practitioner ◽  
Children And Adolescents ◽  
Complex Regional Pain Syndrome ◽  
Musculoskeletal Pain ◽  
Pain Syndrome ◽  
Pain Syndromes ◽  
Pain Medications ◽  
Cross Reference ◽  
Chronic Pain Syndromes

The Oxford Handbook of Rheumatology 4th edition, has been extensively updated to thoroughly review aspects of musculoskeletal pain. Pain pathophysiology is reviewed. Chronic pain and fibromyalgia in adults and in children and adolescents is dealt with in detail. The reader is advised to cross reference from this chapter to Chapters 1–3 in the Handbook, where regional musculoskeletal pain conditions are listed and reviewed. In localized pain syndromes, the chapter has an overview of complex regional pain syndrome (CRPS), which is not infrequently encountered in rheumatology and musculoskeletal clinics. Included in detail for this edition, is the assessment and management of pain in children, which is a highly specialized clinical area of medicine and will be of use to the adult rheumatologist and general practitioner as well as paediatric specialists. Readers should cross reference to Chapter 23 on medications, for ‘pain medications’ in the Handbook

Multiple Sclerosis and Pain: A Medical Focus

2000 ◽  
Vol 2 (3) ◽  
pp. 40-47 ◽  
Author(s):  
Marilyn Kassirer
Keyword(s):  
Multiple Sclerosis ◽  
Chronic Pain ◽  
Joint Pain ◽  
Pain Syndrome ◽  
Surgical Interventions ◽  
Alternative Interventions ◽  
Pain Syndromes ◽  
Drug Treatments ◽  
Patients Experience ◽  
Iatrogenic Pain

Abstract About 65% of multiple sclerosis (MS) patients experience a broad range of both acute and subacute painful syndromes. Acute conditions (eg, trigeminal neuralgia and Lhermitte's syndrome) cause intense, unrelenting pain that may worsen with age and disease progression. Chronic pain (eg, joint pain) is also a component of MS. Pain syndromes, including optic neuritis, complex regional pain syndrome (CRPS), and other less well-known syndromes, may respond to a variety of pharmacologic, surgical, or alternative interventions. MS patients may also experience iatrogenic pain. Some successful drug treatments for pain that are used in combination or alone include anticonvulsants, tricyclics, methylprednisolone, and narcotics. Surgical interventions, percutaneous compression-balloons, and radiofrequency ablation are other viable options for some pain syndromes.

scholarly journals Classification of Chronic Pain at a Multidisciplinary Pain Rehabilitation Clinic

1998 ◽  
Vol 3 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Jan Lidbeck ◽  
Gertie IM Hautkamp ◽  
Ritva A Ceder ◽  
Urban LO Näslund
Keyword(s):  
Chronic Pain ◽  
Musculoskeletal Pain ◽  
Myofascial Pain ◽  
Pain Syndrome ◽  
Pain Clinic ◽  
Psychological Pain ◽  
Pain Syndromes ◽  
Epidemiological Surveys ◽  
Clinical Diagnoses ◽  
Chronic Pain Syndromes

OBJECTIVE: To make a detailed diagnostic analysis of patients with chronic pain syndromes, including classification according to the International Association for the Study of Pain (IASP).DESIGN: Descriptive study of consecutive referrals during a two-year period.SETTING: A multidisciplinary out-patient pain clinic focused on occupational rehabilitation.SUBJECTS: A total of 309 chronic pain patients.METHODS: After a standardized multimodal physical and psychological examination, the chronic pain syndrome of each patient was assigned one or more clinical diagnoses; assigned to an etiological pain category (nociceptive pain, non-nociceptive including idiopathic pain, and psychological pain); and coded diagnostically according to IASP taxonomy.RESULTS: In all, 397 clinical diagnoses were made (ie, a mean of 1.3 diagnoses per patient). A large majority (87%) received a diagnosis of myalgia. Myofascial pain (trigger point syndrome) was diagnosed in two-thirds of the patients and was the most frequent clinical pain syndrome. A total of 51.8% of the pain syndromes were categorized as nociceptive, 43.0% as idiopathic and less than 1% as pain of psychological origin. Classification using the IASP system yielded a very high proportion of nociceptive, musculoskeletal pain syndromes of high intensity, with widespread pain and/or pain located in the neck/shoulder/arm region, and of dysfunctional etiology.CONCLUSIONS: Musculoskeletal pain was very common in this series, and myofascial pain syndromes were the most frequent specific pain disorders. However, myofascial pain had generally gone unrecognized by the referring physician. In contrast to findings of other studies, the incidence of low back pain and of primary psychological pain was low. Comparison of the results with those of Swedish epidemiological surveys showed the frequencies of the diagnoses in this series to be representative of chronic pain syndromes in the Swedish general population.

Quality of Life following Treatment: A Preliminary Study of In- and Outpatients with Chronic Pain

1989 ◽  
Vol 18 (3) ◽  
pp. 271-282 ◽  
Author(s):  
Raymond C. Tait ◽  
Paul N. Duckro ◽  
Ronald B. Margolis ◽  
Richard Wiener
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Pain Syndromes ◽  
Before And After ◽  
Patient Groups ◽  
Methodological Problems ◽  
Preliminary Study ◽  
Different Levels ◽  
Chronic Pain Syndromes

Using a combination of standardized and Likert-type measures of health, disability, and psychological adjustment, this study compared the quality of life reported by thirty-seven inpatients and thirty-six outpatients approximately eight months after completing treatment. While both patient groups reported treatment-related changes, inpatients were significantly more dysfunctional than outpatients both before and after treatment. The pattern of perceived improvement among inpatients reflected particular changes in narcotic use and in “up” time. For outpatients, the pattern of change pointed to increased periods of activity. The data are interpreted to reflect the need for treatments that are tailored to meet the differing levels of dysfunction of patients who present with chronic pain syndromes. Methodological problems of this and other clinical studies that compare treatment effects on patients demonstrating different levels of dysfunction are discussed.

Pain Syndromes Other Than Headache

2016 ◽  
Author(s):  
Edgar L. Ross
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Sensory Processing ◽  
Pain Syndrome ◽  
The Body ◽  
Spinal Cord Dorsal Horn ◽  
Opioid Use ◽  
Nerve Injuries ◽  
Pain Syndromes ◽  
Chronic Pain Syndromes

Pain is experienced within a complex biologic, emotional, psychological, and social context that may defy physical examination, diagnostic procedures, and laboratory tests. This chapter aims to empower internists to improve their medical practices in pain management. It provides a scientific background that covers nociception and how sensory processing occurs at multiple levels in the body. Clinical assessment is detailed, as well as diagnostic categories that include mixed or uncertain chronic pain syndromes (back pain, fibromyalgia, postamputation pain, pain from cancer and bone) and neuropathic pain syndromes (polyneuropathy, mononeuropathy multiplex, ganglionopathy, genetic disorders, focal and regional syndromes). Treatment of chronic pain can be surgical or interventional. Pharmacologic treatment for acute and chronic nociceptive pain includes special considerations for geriatric and terminal patients. For treatment of neuropathic pain, medications are the major component. One tables lists iatrogenic nerve injuries that can cause posttraumatic neuralgia and complex regional pain syndrome. Other tables detail stepwise pharmacologic management of neuropathic pain and cite recommendations on opioid use from the Centers for Disease Control and Prevention. One figure illustrates how pain transducers monitor and influence tissue conditions. Other figures show sensory processing in the spinal cord dorsal horn, physical findings in the feet of patients with bilateral foot pain from small-fiber polyneuropathy, illustrate how examination can identify specific nerve injuries causing chronic pain, and provide classification of chronic pain syndromes. This chapter contains 82 references.

scholarly journals P118 Orthopaedic surgical interventions in a cohort of patients with hypermobility related disorders, compared with chronic pain syndrome patients in a tertiary referral centre

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Sarah Wright ◽  
Puja Mehta ◽  
Anisur Rahman ◽  
Hanadi Kazkaz
Keyword(s):  
Chronic Pain ◽  
Surgical Procedures ◽  
Surgical Intervention ◽  
Pain Syndrome ◽  
Referral Centre ◽  
Beighton Score ◽  
Tertiary Referral Centre ◽  
Surgical Interventions ◽  
Pain Syndromes ◽  
Chronic Pain Syndromes

Abstract Background Mechanisms of pain associated with hypermobility are poorly understood and include nociceptive pain due to structural joint changes, neuropathic pain due to disrupted proprioception, muscle weakness and central sensitisation. The influence of anxiety and low mood is also unknown. There is limited published evidence regarding orthopaedic interventions in hypermobile patients particularly following the updated 2017 Ehlers-Danlos syndrome (EDS) classification criteria. We aimed to evaluate the characteristics of a hypermobility patient cohort who had received surgical interventions and compare these with a patient population with chronic pain syndromes. Methods A retrospective analysis of medical records was conducted of patients attending a tertiary referral centre (University College London Hospital) between January 2018 and December 2018. A hypermobility-related disorders cohort was compared with a cohort of patients with chronic pain syndrome, including fibromyalgia (but without any evidence of hypermobility). Results There were 350 patients (300 females, 50 males) in the hypermobility cohort with a mean age of 36 years (range 18-71 years) at time of clinic review. 63% had hypermobility spectrum disorder or hypermobility syndrome and 37% had EDS (hypermobile, classic, vascular and other rare types). 24% of hypermobile patients had undergone orthopaedic interventions. The Beighton score did not correlate with surgical procedures. 134 patients (121 females, 13 males) with chronic pain syndromes were identified, with a mean age of 51 years (range 26-85 years). 16% of chronic pain patients had received orthopaedic surgery. 76% of hypermobile patients who had orthopaedic interventions were under 50 years old, compared to 23% in the chronic pain cohort. The total number of surgical procedures in the hypermobility cohort was 227 (0.6485 interventions per patient) compared with 25 in the chronic pain cohort (0.1865 interventions per patient); relative risk 3.477 (95% CI 2.42-4.99; P < 0.0001, chi-squared test). 33% of hypermobile patients had surgery on two or more joint groups (including 8 patients who had surgery in four or more joint groups), whereas 95% of chronic patients had surgery on only one joint group. In the hypermobile group the knee (23%) and hips (24%) were the most common site of operative intervention; however in the chronic pain cohort the most common sites were the knee (32%), spine (20%) and shoulders (20%), with only 4% requiring hip surgery. Conclusion Patients with hypermobility have a greater number of surgical procedures at multiple joint sites and at a younger age than patients with chronic pain syndromes, suggesting that mechanical pathology (rather than pain alone) and anticipated surgical success may contribute to the need for surgical intervention. The Beighton score does not appear to be a reliable predictor of surgical intervention. Earlier diagnosis and a holistic, non-operative approach, including physiotherapy and pain management, may reduce the need for surgical procedures. Disclosures S. Wright None. P. Mehta None. A. Rahman None. H. Kazkaz None.

scholarly journals Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review

2021 ◽  
pp. E393-E406
Keyword(s):  
Chronic Pain ◽  
Complex Regional Pain Syndrome ◽  
Case Studies ◽  
Low Dose ◽  
Pain Syndrome ◽  
The United States ◽  
Qualitative Review ◽  
Pain Syndromes ◽  
Low Dose Naltrexone ◽  
Chronic Pain Syndromes

BACKGROUND: Complex regional pain syndrome is a rare, neuropathic disorder that affects fewer than 200,000 individuals in the United States annually. Current treatments often focus on pain management and fall short of relieving symptoms of pain and dystonia in patients. OBJECTIVE: The goal of this systematic qualitative review is to evaluate the evidence for the use of low-dose naltrexone in the treatment of chronic pain syndromes. STUDY DESIGN: This is a systematic review. METHODS: PubMed, Embase, and Web of Science were searched for articles containing the keywords “low-dose naltrexone” AND (“pain” OR “chronic pain” OR “fibromyalgia” OR “complex regional pain syndrome” OR “neuropathic pain” OR “nociceptive pain”) between 1950 and July 17, 2020. A total of 30 publications were systematically reviewed. Exclusion criteria were articles that were unavailable in English, focused on acute pain only, and evaluated only animal models. Case studies were included for the purposes of our qualitative review. RESULTS: Out of 29 articles, we reviewed 11 prospective studies, 10 case studies, 3 systematic reviews, 2 retrospective studies, 2 simulation models, and one combination study. Articles focused on chronic pain syndromes as well as painful rheumatologic disorders and neurological disorders. We found that low-dose naltrexone treatment was positively associated with symptom relief in patients experiencing chronic pain, dystonia, and sleep disturbances. LIMITATIONS: Due to the limited number of available articles focusing on the treatment of complex regional pain syndrome with low-dose naltrexone, the majority of studies analyzed focused on other chronic pain syndromes. CONCLUSIONS: There is a need for additional prospective and interventional studies addressing the use of low-dose naltrexone in the treatment of complex regional pain syndrome symptoms. KEY WORDS: Complex regional pain syndrome, reflex sympathetic dystrophy, low-dose naltrexone, chronic pain, opioid antagonist

scholarly journals Chronic pain syndromes: overlapping phenotypes with common mechanisms

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 255 ◽  
Author(s):  
Geoffrey Owen Littlejohn ◽  
Emma Guymer
Keyword(s):  
Chronic Pain ◽  
Complex Regional Pain Syndrome ◽  
Emotional Distress ◽  
Pain Syndrome ◽  
Physical Factors ◽  
Pain Syndromes ◽  
The Common ◽  
Chronic Pain Syndromes

The common chronic pain syndromes of fibromyalgia, regional pain syndrome, and complex regional pain syndrome have been made to appear separate because they have been historically described by different groups and with different criteria, but they are really phenotypically accented expressions of the same processes triggered by emotional distress and filtered or modified by genetics, psychology, and local physical factors.

Auriculotherapy: Micro-Current Application on the External Ear—Clinical Analysis of a Pilot Study on 57 Chronic Pain Syndromes

1974 ◽  
Vol 02 (04) ◽  
pp. 399-405 ◽  
Author(s):  
Sae-il Chun ◽  
Arthur J. Heather
Keyword(s):  
Chronic Pain ◽  
Pain Syndrome ◽  
Clinical Analysis ◽  
Current Therapy ◽  
Complete Relief ◽  
External Ear ◽  
Current Application ◽  
Pain Syndromes ◽  
The Mean ◽  
Chronic Pain Syndromes

The French neurophysiologist, Paul Nogier, developed a micro-current therapy called "Auriculotherapy" in which the stimulation of the loci of the external ear by electrical currents of various frequencies is applied in order to alleviate pain syndromes or cure certain diseases. For this paper, 46 cases with 57 chronic pain syndromes of various natures were treated with auriculotherapy and the results were analyzed. 20 males and 26 females were treated. The mean age of the patients was 48.3 years and the mean duration of the pain syndromes was 7.7 years. 18 out of 46 patients had undergone from one to five surgical operations to alleviate the same pain syndrome in the past. The "punctoscope" was used for detection of loci to be treated and the "P-type therapuncteur" with a frequency of 1 Hz was used for treatment. The micro-current was applied for a period of 15 seconds on each point per treatment at weekly intervals. One of the criteria used in assessing the degree of pain relief was the subjective description of pain in regard to severity, frequency of attack of pain and necessity of taking analgesics comparing that of pre-treatment to post-treatment. After an average of 7 treatments on 57 chronic pain syndromes: 9 (15.5% of the cases) showed no improvement, 11 (19.3%) showed slight improvement (25% relief of the original pain), 6 (10.5%) showed moderate improvement (50% relief of the original pain), 13 (22.8%) showed good improvement (75% relief of the original pain), and 18 (31.5%) showed excellent improvement (over 75% relief or complete relief).

scholarly journals Sleep disorders and their correction in patients with chronic back pain

2021 ◽  
pp. 201-207
Author(s):  
O. S. Kochergina ◽  
E. F. Rakhmatullina ◽  
B. E. Gubeev
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Back Pain ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Chronic Back Pain ◽  
Pain Syndrome ◽  
Poor Quality ◽  
Chronic Pain Syndrome

Back pain and insomnia (insomnia) significantly impair the quality of life of patients. Pain contributes to the development of sleep disorders and vice versa, poor quality sleep increases pain. Sleep disorders are widespread in the population, and in chronic pain syndrome, almost 70% of patients suffer from insomnia. The National Sleep Association singles out pain as one of the leading causes of sleep disorders. The article discusses a typical clinical case of the combination and interaction of chronic pain syndrome and insomnia. A patient with acute back pain developed a sleep disorder for which therapy was not carried out. The prescribed standard therapy for back pain, which included a non-steroidal anti-inflammatory drug, muscle relaxant, made it possible to relieve pain in a short time. However, the patient’s insomnia not only persisted, but also progressed, which led to the appearance of symptoms of asthenia in the form of fatigue, irritability, decreased performance, and ultimately significantly reduced the quality of life. In order to normalize sleep, the patient was prescribed a histamine H1 receptor blocker from the ethanolamine group, namely the drug Doxylamine. Follow-up observation for 1 year showed no exacerbation of back pain and sleep disturbances. In the treatment of patients with chronic back pain, it is necessary to pay attention to the presence of sleep disturbances and provide appropriate therapy. Today, three groups of hypnotics are used in clinical practice: melatonin receptor agonists (insufficient effectiveness in acute sleep disorders), benzodiazepines (addictive and addictive), and antihistamines. The modern drug Doxylamin belongs to the group of antihistamine hypnotics, has a good efficacy and safety profile and is included in the domestic recommendations for the treatment of insomnia.

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