Endocrine Active Pituitary Tumor

Author(s):  
Amol Raheja ◽  
William T. Couldwell

This chapter presents an illustrative case demonstrating the principles of diagnosis and management in endocrine active pituitary tumor. The index case involves a 30-year-old male patient who presented with phenotypic markers of acromegaly. On radiological and endocrinological evaluation, growth hormone–secreting pituitary macroadenoma was identified. The philosophy of decision-making and management paradigm is discussed to demonstrate the pros and cons of medical, radiation, and surgical options. Technical nuances of the surgical procedure and its complication management are stressed. A brief review of literature is included to elaborate on the current evidence, including outcomes for the various management options for such tumors, with special emphasis on multimodality management.

2018 ◽  
Vol 08 (02) ◽  
pp. e99-e105 ◽  
Author(s):  
Judith Gronbach ◽  
Harald Ehrhardt ◽  
Klaus-Peter Zimmer ◽  
Markus Waitz

AbstractEarly pulmonary interstitial emphysema in extreme preterm neonates is closely linked with respiratory distress syndrome and exposure to mechanical ventilation. In severe cases, maintaining adequate gas exchange aiming to avoid further lung damage and other neonatal morbidities associated with systemic/pulmonary hypoperfusion, prolonged hypoxia, and respiratory acidosis can be challenging and requires in-depth knowledge into the pathophysiology of the disease. Herein, we report on very low birth weight twins who developed early pulmonary interstitial emphysema during noninvasive respiratory support. We further review the current evidence from the literature, specifically addressing on possible preventive measures and the respiratory management options of this acute pulmonary disease in high-risk neonates.


2021 ◽  
pp. 72-76
Author(s):  
Srikanth Kasaraneni ◽  
S. Ravi Raja Kumar ◽  
D. Vamsi Krishna Reddy ◽  
Sowmya Mantha ◽  
Soundarya Mopidevi ◽  
...  

Fungi of the order Mucorales causes an invasive and potentially lethal infection known as mucormycosis. It is a devastating disease in patients with poorly controlled diabetes mellitus and immunocompromised conditions. The infection either begins in the nose and paranasal sinuses due to inhalation of fungal spores or an ulcer or extraction of teeth aids as portal of entry. The infection can also spread to orbital and intracranial structures either through direct invasion or the blood vessels. It is an aggressive infection that needs to be addressed promptly to prevent fatal consequences. We report a case of maxillary necrosis in an uncontrolled diabetic patient due to mucormycois to emphasize importance early diagnosis and treatment of this potentially fatal fungal infection. We briey review the literature of rhinocerebral mucormycosis in terms of its pathogenesis, portal of entry and predisposing factors, incidence and forms, clinical features, diagnosis, differential diagnosis and various management options.


Author(s):  
Andrew Ho ◽  
Tara Bharucha

Although often used as a diagnosis in its own right, double outlet right ventricle is more accurately merely a description of the ventriculo-arterial connection in a congenitally malformed heart, and use of the term must always be allied with further description of the anatomy. In this chapter we describe a term infant born at 3.4 kg following an antenatal diagnosis of double outlet right ventricle (DORV) with noncommitted ventricular septal defect (VSD), side-by-side great arteries and pulmonary stenosis. There was a duct-dependent pulmonary circulation in the neonatal period, and the infant underwent placement of a Blalock-Taussig shunt. Following multi-modality cardiac imaging, he underwent to complete surgical repair at 16 months of age, with VSD enlargement, tunnelled closure of the VSD to commit the left ventricle to the aorta, and augmentation of the pulmonary outflow tract. Through the chapter, we emphasise the importance of a detailed anatomical description and thorough investigation in this family of defects, in order to allow an understanding of the physiology, clinical behaviour and the management options available for individual patients. Learning points in the chapter include discussion regarding the definitions of DORV, detailed descriptions of the major anatomical groups and a synopsis of the more common surgical options.


2018 ◽  
Vol 40 (3) ◽  
pp. 185-190 ◽  
Author(s):  
Giang Huong Nguyen ◽  
Alexander Mohler ◽  
Michelle Leppert ◽  
Cindy Parra ◽  
Yue-Ping Zeng ◽  
...  

Cytopathology ◽  
2019 ◽  
Vol 30 (6) ◽  
pp. 657-661 ◽  
Author(s):  
Aruna Nambirajan ◽  
Varsha Singh ◽  
David Victor Kumar Irugu ◽  
Shipra Agarwal ◽  
Deepali Jain

2012 ◽  
Vol 45 (02) ◽  
pp. 352-363 ◽  
Author(s):  
Atul Parashar ◽  
Ramesh K. Sharma

ABSTRACTManagement of perineal wounds can be very frustrating as these invariably get contaminated from the ano-genital tracts. Moreover, the apparent skin defect may be associated with a significant three dimensional dead space in the pelvic region. Such wounds are likely to become chronic and recalcitrant if appropriate wound management is not instituted in a timely manner. These wounds usually result after tumor excision, following trauma or as a result of infective pathologies like hideradenitis suppurativa or following thermal burns. Many options are available for management of perineal wounds and these have been discussed with illustrative case examples. A review of literature has been done for listing commonly instituted options for management of the wounds in perineum.


HORMONES ◽  
2019 ◽  
Vol 18 (2) ◽  
pp. 197-205 ◽  
Author(s):  
Atousa Najmaldin ◽  
Mojtaba Malek ◽  
Nahid Hashemi Madani ◽  
Mohammad Ghorbani ◽  
Hamideh Akbari ◽  
...  

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