Peripheral Neuropathy

2019 ◽  
pp. 315-353
Author(s):  
Christopher H. Hawkes ◽  
Kapil D. Sethi ◽  
Thomas R. Swift
Keyword(s):  
Peripheral Neuropathy ◽  
Peripheral Nerves ◽  
Nail Changes

This chapter divides peripheral neuropathy into mononeuropathy, radiculopathy, and polyneuropathy. Disorders of major peripheral nerves are highlighted: namely, median, ulnar, radial, sciatic, and femoral nerves, and how their associated dysfunction may be identified speedily. Polyneuropathy is subdivided according to pattern of onset; accompanying pain; axonal or demyelinating; length- or non–length-dependent; inherited or acquired; presence of nerve thickening; occurrence of tremor; skin, hair, or nail changes; deafness; ophthalmoplegia; anosmia; ageusia, or cataract.

Peripheral Neuropathy

2016 ◽  
pp. 297-332
Author(s):  
Christopher H. Hawkes ◽  
Kapil D. Sethi ◽  
Thomas R. Swift
Keyword(s):  
Peripheral Neuropathy ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Peripheral Nerves ◽  
Lower Limbs ◽  
Mononeuritis Multiplex ◽  
Nail Changes ◽  
Tunnel Syndrome ◽  
Hip Flexor

This chapter divides discussion of peripheral neuropathy into sections on mononeuropathy, radiculopathy, and polyneuropathy. Disorders of major peripheral nerves are highlighted— median, ulnar, radial sciatic, and femoral nerves—and how their associated dysfunction may be identified speedily. Carpal tunnel syndrome and unilateral hip flexor weakness are discussed in this section, together with mononeuritis multiplex. Radiculopathy affecting the upper and lower limbs is detailed. Polyneuropathy is subdivided according to pattern of onset; accompanying pain; axonal or demyelinating; length- or non-length dependent; inherited or acquired; presence of nerve thickening; occurrence of tremor; skin, hair, or nail changes; deafness; ophthalmoplegia; anosmia; ageusia; and cataract.

scholarly journals Diabetic peripheral neuropathy: epidemiology, pathogenesis, clinic, diagnostics, treatment

2016 ◽  
Vol 24 (4) ◽  
pp. 139-151 ◽  
Author(s):  
A N Belova ◽  
M N Kudykin ◽  
G E Sheiko
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Peripheral Nerves ◽  
Pain Syndrome ◽  
Common Complication ◽  
Review Of Literature ◽  
Chronic Hyperglycemia ◽  
Progressive Degeneration ◽  
Pathophysiologic Mechanisms

The article contains the review of literature data dedicated to the most common complication associated with diabetes mellitus (DM) - the diabetic peripheral neuropathy (DPN). DPN is regarded as economic burden for any state and significantly influences the quality of patient’s life. DPN is characterized by progressive degeneration of peripheral nerves that leads to pain syndrome, movement disorders and loss of sensation. There is a set of theories of development of DPN, but the major etiological factor is the chronic hyperglycemia. The article describes pathophysiologic mechanisms of DPN development. It is noted that considering high variability of clinical pattern DPN has no unified classification. The article addresses issues related to diagnostics and criteria of establishing the diagnosis. Special attention of the article is dedicated to pathogenic and expected treatment methods.

scholarly journals Management of Peripheral Neuropathy and Cardiovascular Effects in Vitamin B12 Deficiency

2021 ◽  
Vol 10 (5) ◽  
Author(s):  
Nishant Kumar Singh ◽  
Hirni J. Patel ◽  
Mohit Buddhadev ◽  
S P Srinivas Nayak ◽  
Gunosindhu Chakraborthy
Keyword(s):  
Cardiovascular Disease ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Peripheral Nerves ◽  
Vitamin B12 Deficiency ◽  
Cardiovascular Effects ◽  
The Elderly ◽  
Vitamin Deficiencies ◽  
B12 Deficiency ◽  
Artery Disease

Peripheral nerves are susceptible to damage by a wide array of toxins, medications, and vitamin deficiencies. Vitamin B12 (VB12) deficiency neuropathy is a rare debilitating disease that affects mostly the elderly. It is important to consider these etiologies when approaching patients with a variety of neuropathic presentations in this review were have included most relevant and latest information on mechanisms causing Peripheral neuropathy in VB12 deficiency. We also have included cardiovascular disorders and their management. Hyperhomocysteinemia has been implicated in endothelial dysfunction and cardiovascular disease. The association of homocysteine (Hcy) and VB12 with cardiovascular risk factors in patients with coronary artery disease (CAD) has also been studied Keywords: Peripheral Neuropathy, Vitamin B12 Deficiency, Cardiovascular Disease and Homocysteine.

Assessment of Peripheral Nerves With Shear Wave Elastography in Type 1 Diabetic Adolescents Without Diabetic Peripheral Neuropathy

2018 ◽  
Vol 38 (6) ◽  
pp. 1583-1596 ◽  
Author(s):  
Mine Aslan ◽  
Ahmet Aslan ◽  
Hamdi Cihan Emeksiz ◽  
Fatma Candan ◽  
Servet Erdemli ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Shear Wave ◽  
Diabetic Peripheral Neuropathy ◽  
Peripheral Nerves ◽  
Shear Wave Elastography

High resolution ultrasonography of peripheral nerves in diabetic peripheral neuropathy

2019 ◽  
Vol 67 (7) ◽  
pp. 71 ◽  
Author(s):  
Rashmi Dixit ◽  
Youdhwir Singh ◽  
Sapna Singh ◽  
Sandeep Garg ◽  
Neera Chowdhury
Keyword(s):  
Peripheral Neuropathy ◽  
High Resolution ◽  
Diabetic Peripheral Neuropathy ◽  
Peripheral Nerves ◽  
High Resolution Ultrasonography

scholarly journals Peripheral Neuropathy in Oxalosis. A Case Report with Electron Microscopic Observations

1976 ◽  
Vol 3 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Juan M. Bilbao ◽  
Henry Berry ◽  
Joseph Marotta ◽  
Roderick C. Ross
Keyword(s):  
Renal Failure ◽  
Peripheral Neuropathy ◽  
Peripheral Nerves ◽  
Axonal Degeneration ◽  
Primary Hyperoxaluria ◽  
Renal Calculi ◽  
Chronic Hemodialysis ◽  
Cell Cytoplasm ◽  
Electron Microscopic ◽  
Segmental Demyelination

SUMMARY:A 61 year old man had chronic renal failure because of oxaluria and renal calculi. Two years before death, while on hemodialysis, he developed severe progressive peripheral neuropathy. At autopsy calcium oxalate crystals were found in the peripheral nerves and other tissues. Nerve lesions included segmental demyelination, axonal degeneration and crystalline deposits within the myelin sheath. Ultrastructurally there were foci of osmiophilic granular material within myelin lamellae and endoneurium, and pleomorphic lamellar bodies in the perinuclear Schwann cell cytoplasm.It is probable that chronic hemodialysis favors the deposition of oxalate in the Schwann cells and the development of neuropathy in patients with primary hyperoxaluria and renal failure.

scholarly journals Targeted fascicular biopsy in a patient with prostate cancer

2018 ◽  
Vol 44 (videosuppl1) ◽  
pp. V7 ◽  
Author(s):  
Jonathan J. Stone ◽  
Megan C. Kaszuba ◽  
Robert J. Spinner
Keyword(s):  
Prostate Cancer ◽  
Peripheral Neuropathy ◽  
Sciatic Nerve ◽  
Peripheral Nerves ◽  
Neurological Deficits ◽  
Link Type ◽  
History Of ◽  
History Of Cancer ◽  
New Onset

Patients who present with a history of cancer and the new onset of lumbosacral or peripheral neuropathy should be evaluated for the potential of metastasis. Targeted fascicular biopsy can be useful to diagnose atypical lesions within peripheral nerves in patients with major or progressive neurological deficits. In this video, the authors demonstrate the technique of targeted fascicular biopsy of the sciatic nerve in a 63-year-old man with a history of prostate cancer.The video can be found here: https://youtu.be/PTOX9XxNBDU.

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