Other nuclear cardiological investigations

2017 ◽  
Author(s):  
Nikant Sabharwal ◽  
Parthiban Arumugam ◽  
Andrew Kelion
Keyword(s):  
Cardiac Amyloidosis ◽  
Systolic Heart Failure ◽  
Clinical Aspects ◽  
Pentadecanoic Acid ◽  
Clinical Value ◽  
Imaging Protocol ◽  
Physiological Properties ◽  
Iodine 123 ◽  
Artery Disease ◽  
Meta Iodo Benzyl Guanidine

This chapter explains the imaging protocol physiological properties and clinical value of other nuclear cardiological investigations. It covers iodine-123-labelled radiopharmaceuticals, iodine-123-meta-iodo-benzyl-guanidine (123I-MIBG), β‎-methyl-p-[123I]iodo-phenyl-pentadecanoic acid (123I-BMIPP), and Tc-phosphate scintigraphy for cardiac amyloidosis, exploring both practical and clinical aspects. Specific prognoses and diagnoses are also detailed for the relevant investigation, including systolic heart failure, coronary artery disease, and cardiac amyloidosis.

Detection of coronary artery disease by iodine-123-labeled iodophenyl-9-methyl pentadecanoic acid SPECT: Comparison with thallium-201 and iodine-123 BMIPP SPECT

2000 ◽  
Vol 14 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Kazuki Fukuchi ◽  
Shinji Hasegawa ◽  
Yasushi Ito ◽  
Hitoshi Yamaguchi ◽  
Jun Yoshioka ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Thallium 201 ◽  
Pentadecanoic Acid ◽  
Iodine 123 ◽  
Artery Disease

Noninvasive Assessment of Coronary Artery Disease – Anatomical versus Functional Imaging and the Marginal Role of Exercise Electrocardiograms

Praxis ◽  
2020 ◽  
Vol 109 (14) ◽  
pp. 1141-1149
Author(s):  
Martina Boscolo Berto ◽  
Dominik C. Benz ◽  
Christoph Gräni
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Functional Imaging ◽  
Clinical Aspects ◽  
Industrialized Countries ◽  
Coronary Syndromes ◽  
Pros And Cons ◽  
Noninvasive Assessment ◽  
Artery Disease ◽  
European Society Of Cardiology

Abstract. Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the industrialized countries. Assessment of symptomatic patients with suspected obstructive CAD is a common reason for a clinical visit. Noninvasive anatomical and functional imaging are established tools to rule-in and rule-out CAD, to assess the severity of disease and to determine the potential risk of future cardiovascular events. In this review, we discuss the updated Guidelines from the European Society of Cardiology on Chronic Coronary Syndromes and explore the different imaging modalities used in current clinical practice for the noninvasive assessment of CAD. The pros and cons of each method, especially comparing anatomical and functional testing, are presented. Furthermore we we address the practical clinical aspects in the selection of the optimal noninvasive tests according to clinical need.

scholarly journals Simultaneous dual myocardial imaging with iodine-123-.BETA.-methyl iodophenyl-pentadecanoic acid (BMIPP) and thallium-201 in patients with coronary heart disease.

1994 ◽  
Vol 58 (2) ◽  
pp. 107-115 ◽  
Author(s):  
KEI TAWARAHARA ◽  
CHINORI KURATA ◽  
TAKAHISA TAGUCHI ◽  
SHIGEYUKI AOSHIMA ◽  
KENICHI OKAYAMA ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Thallium 201 ◽  
Myocardial Imaging ◽  
Pentadecanoic Acid ◽  
Iodine 123

Abstract 16124: Implantable Cardioverter Defibrillators in Patients With Hereditary Transthyretin Cardiac Amyloidosis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Sreeram Yalamanchili ◽  
Matthew T Brown ◽  
Evan A Blank ◽  
Melissa A Lyle ◽  
Kunal N Bhatt
Keyword(s):  
Heart Failure ◽  
Ventricular Tachycardia ◽  
Cardiac Amyloidosis ◽  
Clinical Decision Making ◽  
Systolic Heart Failure ◽  
Heart Association ◽  
High Rate ◽  
Implantable Cardioverter Defibrillators ◽  
Antitachycardia Pacing ◽  
Icd Implantation

Introduction: Implantable cardioverter defibrillator (ICD) implantation in patients with cardiac amyloidosis is controversial, with no clear guidelines for clinical decision-making.. The role of ICD implantation in hereditary Transthyretin Amyloid Cardiomyopathy (hATTR-CM) is unclear. We sought to establish the burden of ventricular arrhythmias and the outcomes of ICD implantation in a single center cohort of hATTR-CM patients. Methods: A total of 69 patients with a confirmed diagnosis of hATTR-CM from genetic testing, and technetium pyrophosphate (PYP) scanning, or endomyocardial biopsy underwent retrospective chart review for demographic, clinical, and arrhythmia data. Results: Seventy-four percent of the cohort was male, with a mean age at diagnosis of 68 (SD=18 years). Sixty-five patients (94.2%) patients were African-American; all of whom carried the Valine 122 Isoleucine mutation. Most had systolic heart failure (New York Heart Association Staging II [18, 26%] and III [40, 58.8%]); 37 (54%) patients had an LVEF ≤ 35%. Thirty-six (52.2%) patients had documented episodes of non-sustained ventricular tachycardia (NSVT), three (4.3%) with ventricular tachycardia (VT), and one (1.5%) with ventricular fibrillation (VF). A total of 15 (21.7%) patients had ICDs placed for prevention of sudden cardiac death in the setting of low LVEF (EF <35%). All recorded VT/VF episodes occurred in three patients with ICDs. Of these patients, one experienced two episodes of VT each successfully abated by antitachycardia pacing (ATP), another experienced a single episode of VT abated by ATP, while the final experienced VF with successful 36J shock as well as two episodes of VT each successfully treated with 36J shocks. No inappropriate ICD shocks were delivered, however, there were two instances of ATP for inappropriately detected atrial arrhythmias. Conclusions: In a cohort of patients with hATTR-CM, we observed a high incidence of NSVT, yet only 41% of patients with severe systolic heart failure had ICDs implanted. A high rate of successful defibrillation and no inappropriate ICD shocks were noted, suggesting that ICDs should be strongly considered, and may be underutilized, in patients with systolic heart failure and/or arrhythmias in the setting of hATTR-CM.

Abstract 5818: Stress Thallium-201/Rest Tc-99m Sequential Dual Isotope High-Speed Myocardial Perfusion Imaging

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Daniel S Berman ◽  
Sean W Hayes ◽  
Arik Wolak ◽  
Xingping Kang ◽  
Louise E Thomson ◽  
...  
Keyword(s):  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
High Speed ◽  
Invasive Coronary Angiography ◽  
Thallium 201 ◽  
Imaging Protocol ◽  
Dual Isotope ◽  
Artery Disease

Recent advances in gamma camera technology are providing opportunities for novel high-speed myocardial perfusion imaging (HS-MPI) protocols. We aimed to develop and evaluate a stress thallium-201 (Tl-201) and rest Tc-99m sestamibi or tetrofosmin imaging protocol that could reduce imaging time and radiation burden. Methods: We studied 410 consecutive patients undergoing exercise or pharmacologic low-dose stress Tl-201 HS-MPI (4 min/acquisition) in the semi-upright and supine positions (D-SPECT, Spectrum-Dynamics) followed by rest Tc-99m sestamibi (n= 139) or tetrofosmin (n= 271) with immediate post-injection rest imaging. Of 330 patients with no known coronary artery disease (CAD), 29 patients also underwent invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) within a three month period and 36 had a < 5% pre-test likelihood of CAD (LLk). Despite low injected doses [Tl-201 (2.2± 0.3 mCi) and Tc-99m sestamibi or tetrofosmin (8.9± 2.4 mCi), the 3 acquisition MPI protocol (2 stress/1 rest) was accomplished < 20 minutes. The quality of stress and resting image was good to excellent in >96% of cases; importantly, no or minor extracardiac activity was seen on 99% of stress and 93% of rest images. HS-MPI was nondiagnostic or uninterpretable in only 2/410 patients. In the 29 patients with CCTA or ICA, the sensitivity and specificity for the detection of ≥70% stenosis were 73% and 89%, respectively, and in 15 patients with ICA, the sensitivity was 89%. The normalcy rate in the LLk group was 100%. A fast stress Tl-201/rest Tc-99m HS-MPI protocol offers promise as a time-efficient, low radiation dose method, in which the superior qualities of Tl-201 for stress imaging and of Tc-99m agents for rest imaging can be utilized.

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