Special conditions: revascularization

ESC CardioMed ◽  
2018 ◽  
pp. 935-938
Author(s):  
Miguel Sousa-Uva ◽  
Stuart J. Head
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery ◽  
Medical Therapy ◽  
Artery Bypass ◽  
Management Strategies ◽  
Optimal Medical Therapy ◽  
Cardiac Events ◽  
Lifestyle Modifications ◽  
Patients With Diabetes ◽  
Artery Disease

Patient with diabetes mellitus (DM) are at increased risk for adverse cardiovascular events regardless of symptoms, and coronary artery disease (CAD) is the leading cause of death. Approximately one-third of patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have DM with inferior outcomes of these procedures compared with patients without DM. In patients with stable angina and DM, optimal medical therapy, control of obesity, and lifestyle modifications are key and common to all management strategies. A randomized comparison of prompt revascularization and optimal medical therapy versus optimal medical therapy alone in patients with demonstrated ischaemia and documented CAD showed no benefit in survival or major adverse cardiac events rate with revascularization except in patients with more severe CAD who were deemed best treated with CABG. The decision on whether or not to revascularize a patient with type 2 DM is dependent upon angina class and extent of ischaemia by non-invasive tests and extent of CAD. The Future Revascularization Evaluation in patients with Diabetes Mellitus: Optimal Management of Multivessel disease (FREEDOM) trial, randomized patients with DM to PCI or CABG using first-generation drug-eluting stents and showed better survival and lower combined all-cause death, myocardial infarction, or stroke after 5-year follow-up with CABG. Overall, the benefit of CABG increases with increased disease complexity. As both PCI and CABG are continuously evolving, making trial results rapidly obsolete, decision-making about revascularization strategy for individual patients with DM and CAD require a Heart Team discussion.

Management of the Asymptomatic Diabetic Patient with Evidence of Ischaemia

2010 ◽  
Vol 6 (1) ◽  
pp. 62
Author(s):  
Dimitrios Bliagos ◽  
Ajay J Kirtane ◽  
Jeffrey W Moses ◽  
◽  
◽  
...  
Keyword(s):  
Coronary Artery ◽  
Medical Therapy ◽  
Artery Bypass ◽  
Coronary Intervention ◽  
Diabetic Patients ◽  
Ageing Population ◽  
Patients With Diabetes ◽  
Risk Patients ◽  
Asymptomatic Diabetic Patient ◽  
Artery Disease

In the US, a total of 23.6 million people have diabetes, representing 7.8% of the population, and the prevalence of diabetes is on the rise due to an increasingly sedentary lifestyle, increasing obesity and an ageing population. Coronary artery disease is the leading cause of death in patients with diabetes, despite a reduction in cardiovascular events over the last 50 years, due in part to better medical therapy. Asymptomatic diabetic patients with evidence of ischaemia on stress testing have higher cardiac mortality; increasing amounts of ischaemia are associated with higher mortality rates. Revascularisation of high-risk patients, or those with significant ischaemia, has the potential to improve outcomes in this patient population. The choice of which revascularisation strategy to choose – either percutaneous coronary intervention (PCI) or coronary artery bypass grafting – should be carefully individualised, and must always be implemented against the background of optimal medical therapy.

Long-term prognosis after percutaneous or surgical revascularization in patients with diabetes mellitus and complex coronary artery disease- a systematic review and meta analysis

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
A Abdul Razzack ◽  
S Mandava ◽  
S Pothuru ◽  
S Adeel Hassan ◽  
D Missael Rocha Castellanos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Bypass ◽  
Left Main ◽  
All Cause Mortality ◽  
Patients With Diabetes ◽  
Artery Disease

Abstract Funding Acknowledgements Type of funding sources: None. Background-Whether Coronary artery bypass grafting (CABG) confers a survival benefit in patients with diabetes mellitus(DM) and complex coronary artery disease (CAD), including left main CAD and multivessel coronary disease (MVD) after a follow up period ≥ 5 years remains unknown. Methods- Electronic databases (PubMed, Embase, Scopus, Cochrane) were searched from inception to December 12th 2020. Using a generic invariance weighted random effects model, Hazard ratios (HRs) and their 95% confidence intervals (CIs) from individual studies were converted to Log HRs and corresponding standard errors, which were then pooled. The primary outcome of interest was all-cause mortality and major adverse cardiac and cerebrovascular events (MACCE) which was defined as a composite of death, myocardial reinfarction and stroke at ≥ 5 years. Results-A total of 8 studies with 13336 participants(PCI = 6783, CABG = 6553)were included in our analysis. Mean age was 54.6 and 55.3 in the PCI-DES and CABG groups respectively. The 5-yr follow-up outcomes including all-cause mortality (HR 1.37; 95%CI 1.15-1.65; p = 0.0006, I2 = 0)and MACCE (HR 1.48; 95%CI 1.29-1.69; p < 0.00001, I2 = 0) were significantly higher with PCI as compared to CABG. Furthermore, at >5 year follow-up, all-cause mortality (HR 1.35; 95%CI 1.10-1.66; p = 0.004, I2 = 37) and MACCE (HR 1.98; 95%CI 1.85-2.12; p < 0.00001, I2 = 0) had similar outcomes. Conclusion-Amongst patients with DM and Complex CAD ( left main/MVD), CABG was associated with improved long-term mortality and freedom from MACCEs as opposed to PCI-DES. CABG is the preferred revascularization strategy in patients with complex anatomic disease and concurrent diabetes. Abstract Figure.

scholarly journals Kesintasan Lima Tahun Pasien Penyakit Jantung Koroner Tiga Pembuluh Darah dengan Diabetes Melitus yang Menjalani Bedah Pintas Koroner, Intervensi Koroner Perkutan atau Medikamentosa di Rumah Sakit dr. Cipto Mangunkusumo

2017 ◽  
Vol 3 (2) ◽  
pp. 60
Author(s):  
Andreas Arie Setiawan ◽  
Marulam Panggabean ◽  
M Yamin ◽  
Siti Setiati
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Medical Therapy ◽  
Therapy Group ◽  
Artery Bypass ◽  
Syntax Score ◽  
Artery Disease ◽  
Better Than ◽  
Diabetes Melitus

Pendahuluan. Hasil revaskularisasi pada pasien diabetes melitus (DM) dengan penyakit jantung koroner 3 pembuluh darah (PJK 3PD) dengan bedah pintas koroner (BPK) lebih baik dibandingkan intervensi koroner perkutan (IKP) atau medikamentosa. BPK tidak selalu menjadi prosedur yang dikerjakan meskipun sudah direkomendasikan sesuai Skor Syntax. Selain itu, tidak semua pasien bersedia menjalani BPK atau IKP. Perlu diketahui apakah pilihan revaskularisasi tersebut mempengaruhi kesintasan 5 tahun.Metode. Penelitian ini merupakan studi kohort retrospektif dengan pendekatan analisis kesintasan untuk meneliti kesintasan 5 tahun pasien PJK 3PD DM yang menjalani tindakan BPK, IKP atau medikamentosa. Penelitian dilakukan dengan menggunakan data sekunder 126 pasien PJK 3PD DM yang menjalani BPK, IKP, maupun medikamentosa di Rumah Sakit dr. Cipto Mangunkusumo (RSCM) Jakarta pada tahun 2006-2007 dan diikuti sampai dengan tahun 2011-2012 dengan dilihat adakah kejadian meninggal.Hasil. Kesintasan terbaik diketahui yaitu pada kelompok BPK (93,5%). Proporsi kematian terbesar terdapat pada kelompok medikamentosa (36,1%). Selain itu, hasil analisis menunjukkan bahwa kelompok IKP memiliki kesintasan yang lebih baik dibanding medikamentosa (69,5% vs 63,9%). Meskipun tidak bermakna secara statistik, namun pada kelompok IKP proporsi keluhan yang ditemukan setelah tindakan lebih sedikit dibanding kelompok medikamentosa (52% vs 38%). Skor Syntax yang berperan menilai kompleksitas stenosis diketahui turut menentukan kesintasan (p=0,039).Simpulan. Kesintasan 5 tahun pasien PJK 3PD dengan DM yang paling baik didapatkan pada kelompok yang menjalani BPK. Kesintasan 5 tahun pasien PJK 3PD dengan DM yang menjalani IKP lebih baik dibandingkan medikamentosa, namun secara statistik tidak bermakna. Faktor yang berpengaruh pada kesintasan 5 tahun pasien PJK 3PD adalah kompleksitas stenosis yang dilihat dengan menggunakan skor Syntax.Kata kunci: DM, kesintasan 5 tahun, PJK 3PD Five-Year Survival in Patients with 3-Vessels Coronary Artery Disease and Diabetes Mellitus Undergoing Coronary Artery Bypass Graft, Coronary Percutaneus Intervention, or Receiving Pharmacological Therapy in Cipto Mangunkusumo HospitalIntroduction. Revascularization results in patients with diabetes mellitus (DM) and coronary artery disease involving 3 vessels (CAD 3VD) undergo coronary artery bypass surgery (CABG) are better compared with those undergo percutaneous coronary intervention (PCI) or medical therapy. However, CABG is not always done despite being recommended in accordance with Syntax Score because some patients unwilling to undergo CABG or PCI . This trial determined whether the choice of revascularization affect 5-years survival. Methods. This was a retrospective cohort study with survival analysis to examine the 5-years survival rate of CAD 3VD DM patients undergoing CABG, PCI, or medical therapy. The study was conducted using secondary data of 126 CAD 3VD DM patients who underwent CABG, PCI, or medical therapy at Cipto Mangunkusumo Hospital in 2006-2007 and followed up to 2011-2012 if there any incident died. Results. Best survival was seen in the CABG group (93.5%). The largest proportion of death occured in the medical therapy group (36.1%). The CABG survival was significantly better than the IKP (p=0.01) and medical therapy (p=0.001). PCI group had better survival than medical therapy (69.5% vs. 63.9%). Although not statistically significant, but the proportion of complaints after revascularization in PCI group were found less than medical therapy group (52% vs. 38%). Syntax score that assesses the complexity of stenosis had a significant association with survival (p 0.039). Conclusions.5-years survival of CAD 3VD DM patients is best obtained in the group that underwent CABG. 5-year survival of CAD 3VD DM patients who underwent PCI better than medical therapy but was not statistically significant. Factor that affect the 5-years survival is the complexity stenosis viewed by the Syntax score. Keywords: 5-years survival, CAD 3VD,DM

P187 Late outcomes of all patients at a single center with diabetes mellitus undergoing SYNTAX scoring after angiographic screening for the FREEDOM trial

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
G Femia ◽  
S Kim ◽  
S Burgess ◽  
M Eftal ◽  
I Ullah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Medical Therapy ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Artery Bypass Grafting ◽  
Vessel Disease ◽  
Patients With Diabetes

Abstract Background The Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multi-Vessel Disease (FREEDOM) trial randomized only a minority of screened patients with diabetes mellitus (DM) and 2-3 vessel disease (MVD), representing an high risk diabetic MVD cohort. Methods Consecutive patients with DM underwent angiographic screening from June 2006  to March 2010 at Liverpool Hospital, Sydney, Australia, for the FREEDOM trial; SYNTAX Scores (SS) were subsequently performed. Patients had late follow-up to determine late rates of death, non-fatal MI and stroke. Results Among 1263 patients with DM 833 (66%) had 0-1 vessel disease and 430 (34%) had MVD of whom 139 had prior coronary artery bypass grafting (CABG), and SS were 0 in 272, 1-9 in 336, 10-22 in 264, 23-32 in 109, and 271 patients had SS ≥33. Revascularisation was performed by coronary artery bypass grafting (CABG) in 139 (11%), 486 (38%) underwent PCI, and 638 (51%) did not undergo a revascularization procedure; respective mean ages were 63.5, 64.2 and 64.7 years; p = 0.39, and presentation rates with an ACS were 52%, 57% and 37%; p < 0.05. Amongst patients with MVD, those undergoing CABG had lower rates of MACE than either PCI or medical therapy (22%, 40%, and 51% respectively; p < 0.001). Kaplan-Meier curves (Figure) with respect to SS and late events are shown for: A) Death; B) Non-fatal MI; C) Death/MI/Stroke; D) Late Revascularization. Multi-variable analyses found independent predictors of late mortality were age >75 (HR 6.2), prior MI (HR 1.1), prior CABG (HR 1.6); and LVEF <40% (all p < 0.05). Predictors of late MI were older age, ACS presentation at screening, LVEF < 40% and insulin use. Conclusions Among diabetic patients who screened for the FREEDOM Trial, among 34% with MVD CABG was associated with lower rates of non-fatal MI and MACE compared to PCI and medical therapy. The poorest outcomes were observed in DM patients with MVD managed with medical therapy alone. Abstract P187 Figure. SYNTAX scores &late events in diabetics

Features of diabetes mellitus in very elderly patients

2019 ◽  
Vol 1 (9) ◽  
pp. 13-19
Author(s):  
S. V. Topolyanskaya ◽  
T. M. Kolontai ◽  
O. N. Vaculenko ◽  
L. I. Dvoretski
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Elderly Patients ◽  
Very Elderly ◽  
Younger Patients ◽  
Patients With Diabetes ◽  
Artery Disease

Modern concepts about features of diabetes mellitus in very elderly patients are described in the article. Special attention to the therapeutic methods of management of very elderly patients with diabetes mellitus has been devoted. The results of diabetes mellitus study in patients with coronary artery disease older than 75 years in comparison with younger patients are presented.

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