Chronic leukaemia

2018 ◽  
Author(s):  
Chris Bunch
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Chronic Lymphocytic Leukaemia ◽  
Myeloid Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Cell Types ◽  
Myeloproliferative Disorder ◽  
Haematopoietic Stem Cell ◽  
Low Grade ◽  
Chronic Leukaemia ◽  
Different Cell Types

In the chronic leukaemias, leukaemogenesis occurs in two different cell types (and possibly even two different anatomical sites), leading to two very different forms of the disease: chronic myeloid leukaemia and chronic lymphocytic leukaemia. Chronic myeloid leukaemia is best thought of as a myeloproliferative disorder. It is a clonal disorder of the haematopoietic stem cell, leading to overproduction of the myeloid cells: neutrophils and their precursors, basophils and eosinophils. By contrast, chronic lymphocytic leukaemia can be viewed as a low-grade lymphoma. It is a clonal disorder of mature B-lymphocytes (possibly memory B-cells). This chapter reviews the causes, diagnosis, and management of these two forms of chronic leukaemia.

scholarly journals A Case of Chronic Lymphocytic Leukaemia Occurring During Treatment of Chronic Myeloid Leukaemia

2016 ◽  
Vol 32 (S1) ◽  
pp. 156-158
Author(s):  
Marina Dokic ◽  
Ivana Urosevic ◽  
Ivanka Savic ◽  
Borivoj Sekulic ◽  
Aleksandar Savic ◽  
...  
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Chronic Lymphocytic Leukaemia ◽  
Myeloid Leukaemia ◽  
Lymphocytic Leukaemia

scholarly journals Dasatinib-induced response in a rare case of chronic lymphocytic leukaemia associated with chronic myeloid leukaemia

2009 ◽  
Vol 146 (2) ◽  
pp. 222-223 ◽  
Author(s):  
Cristina Tecchio ◽  
Ilaria Nichele ◽  
Giuseppe Todeschini ◽  
Giovanni Pizzolo ◽  
Achille Ambrosetti
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Chronic Lymphocytic Leukaemia ◽  
Myeloid Leukaemia ◽  
Rare Case ◽  
Lymphocytic Leukaemia ◽  
Induced Response

scholarly journals Blastic plasmacytoid dendritic cell neoplasm in the background of myeloproliferative disorder and chronic lymphocytic leukaemia

2019 ◽  
Vol 12 (7) ◽  
pp. e230332 ◽  
Author(s):  
Abdul Moiz Khan ◽  
Ayesha Munir ◽  
Mihir Raval ◽  
Syed Mehdi
Keyword(s):  
Dendritic Cell ◽  
Chronic Lymphocytic Leukaemia ◽  
Lymphocytic Leukaemia ◽  
Treatment Guidelines ◽  
Plasmacytoid Dendritic Cell ◽  
Disease Patient ◽  
Myeloproliferative Disorder ◽  
Treatment Modalities ◽  
Intrathecal Methotrexate ◽  
Cell Neoplasm

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare haematological malignancy defined by concurrent expression of CD4, CD56, BCL-2 and CD123. The disease has a very poor prognosis and there are no well-established treatment guidelines. We describe a case of BPDCN in a 65-year-old female patient with myeloproliferative disorder (essential thrombocythemia) and chronic lymphocytic leukaemia. She presented with rapidly progressive facial and scalp lesions. Skin biopsy confirmed BPDCN and the imaging revealed widespread disease. Patient was started on hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone) and intrathecal methotrexate. Due to progression on initial treatment, she was treated with decitabine and venetoclax (BCL-2 inhibitor). However, patient continued to deteriorate and died after 4 months from initial diagnosis. We emphasise on the clinical features, emerging treatment modalities and prognosis of BPDCN.

scholarly journals FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology

2008 ◽  
Vol 3 ◽  
pp. BMI.S592 ◽  
Author(s):  
Michael J. Walsh ◽  
Maneesh N. Singh ◽  
Helen F. Stringfellow ◽  
Hubert M. Pollock ◽  
Azzedine Hammiche ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Principal Component ◽  
Cell Types ◽  
Cervical Cytology ◽  
Low Grade ◽  
High Grade ◽  
Linear Discriminant ◽  
Ftir Microspectroscopy ◽  
Category Variance ◽  
Different Cell Types

Infrared (IR) absorbance of cellular biomolecules generates a vibrational spectrum, which can be exploited as a “biochemical fingerprint” of a particular cell type. Biomolecules absorb in the mid-IR (2–20 μm) and Fourier-transform infrared (FTIR) microspectroscopy applied to discriminate different cell types (exfoliative cervical cytology collected into buffered fixative solution) was evaluated. This consisted of cervical cytology free of atypia (i.e. normal; n = 60), specimens categorised as containing low-grade changes (i.e. CIN1 or LSIL; n = 60) and a further cohort designated as high-grade (CIN2/3 or HSIL; n = 60). IR spectral analysis was coupled with principal component analysis (PCA), with or without subsequent linear discriminant analysis (LDA), to determine if normal versus low-grade versus high-grade exfoliative cytology could be segregated. With increasing severity of atypia, decreases in absorbance intensity were observable throughout the 1,500 cm–1 to 1,100 cm–1 spectral region; this included proteins (1,460 cm–1), glycoproteins (1,380 cm–1), amide III (1,260 cm–1), asymmetric (νas) PO2– (1,225 cm–1) and carbohydrates (1,155 cm–1). In contrast, symmetric (νs) PO2–(1,080 cm–1) appeared to have an elevated intensity in high-grade cytology. Inter-category variance was associated with protein and DNA conformational changes whereas glycogen status strongly influenced intra-category. Multivariate data reduction of IR spectra using PCA with LDA maximises inter-category variance whilst reducing the influence of intra-class variation towards an objective approach to class cervical cytology based on a biochemical profile.

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