Focal therapy for prostate cancer

Mapping Intimacies ◽

10.1093/med/9780199659579.003.0065 ◽

2017 ◽

Author(s):

Hashim Uddin Ahmed ◽

Louise Dickinson ◽

Mark Emberton

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Cancer Control ◽

Focal Therapy ◽

Solid Organ ◽

Ground Tissue ◽

Perioperative Morbidity ◽

Ablative Therapies ◽

Almost All

Minimally-invasive therapies in localized prostate cancer offer the potential to reduce side effects and the healthcare burden/costs associated with radical modalities such as surgery or radiotherapy. As radical treatments carry significant perioperative morbidity (wound infection, haemorrhage, hospital stay), potentially life-long side effects (such as incontinence, erectile dysfunction, rectal toxicity), and fail to cure many men, ablative therapies that reduce treatment burden while retaining acceptable cancer control have increasingly become areas of evaluation. This chapter reviews the role of these approaches and the therapeutic dilemma that men with localized low volume prostate cancer currently face as in the context of novel therapies which aim to find a middle ground—tissue-preserving focal therapy—that follows the paradigm of almost all other solid organ cancers.

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The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer

High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications ◽

10.5772/intechopen.71996 ◽

2018 ◽

Cited By ~ 1

Author(s):

Sunao Shoji ◽

Akira Miyajima

Keyword(s):

Magnetic Resonance Imaging ◽

Prostate Cancer ◽

Magnetic Resonance ◽

High Intensity ◽

Focused Ultrasound ◽

Focal Therapy ◽

High Intensity Focused Ultrasound ◽

Localized Prostate Cancer ◽

Resonance Imaging

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Multiparametric MRI in Biopsy Guidance for Prostate Cancer: Fusion-Guided

BioMed Research International ◽

10.1155/2014/439171 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 25

Author(s):

Jason T. Rothwax ◽

Arvin K. George ◽

Bradford J. Wood ◽

Peter A. Pinto

Keyword(s):

Prostate Cancer ◽

Specific Antigen ◽

Elevated Serum ◽

Focal Therapy ◽

Multiparametric Mri ◽

Solid Organ ◽

Prostate Biopsies ◽

Innovative Methods ◽

Early Phase Trials ◽

Clinically Significant

Prostate cancer (PCa) is the most common solid-organ malignancy among American men and the second most deadly. Current guidelines recommend a 12-core systematic biopsy following the finding of an elevated serum prostate-specific antigen (PSA). However, this strategy fails to detect an unacceptably high percentage of clinically significant cancers, leading researchers to develop new, innovative methods to improve the effectiveness of prostate biopsies. Multiparametric-MRI (MP-MRI) has emerged as a promising instrument in identifying suspicious regions within the prostate that require special attention on subsequent biopsy. Fusion platforms, which incorporate the MP-MRI into the biopsy itself and provide active targets within real-time imaging, have shown encouraging results in improving the detection rate of significant cancer. Broader applications of this technology, including MRI-guided focal therapy for prostate cancer, are in early phase trials.

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The Role of Targeted Focal Therapy in the Management of Low-Risk Prostate Cancer: Update on Current Challenges

Prostate Cancer ◽

10.1155/2012/587139 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 5

Author(s):

Daniel W. Smith ◽

Diliana Stoimenova ◽

Khadijah Eid ◽

Al Barqawi

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Specific Antigen ◽

Three Dimensional ◽

Focal Therapy ◽

The United States ◽

Psa Testing ◽

Three Dimensional Mapping ◽

Risk Prostate Cancer ◽

Low Risk Prostate Cancer

Prostate cancer is one of the most prevalent cancers among men in the United States, second only to nonmelanomatous skin cancer. Since prostate-specific antigen (PSA) testing came into widespread use in the late 1980s, there has been a sharp increase in annual prostate cancer incidence. Cancer-specific mortality, though, is relatively low. The majority of these cancers will not progress to mortal disease, yet most men who are diagnosed opt for treatment as opposed to observation or active surveillance (AS). These men are thus burdened with the morbidities associated with aggressive treatments, commonly incontinence and erectile dysfunction, without receiving a mortality benefit. It is therefore necessary to both continue investigating outcomes associated with AS and to develop less invasive techniques for those who desire treatment but without the significant potential for quality-of-life side effects seen with aggressive modalities. The goals of this paper are to discuss the problems of overdiagnosis and overtreatment since the advent of PSA screening as well as the potential for targeted focal therapy (TFT) to bridge the gap between AS and definitive therapies. Furthermore, patient selection criteria for TFT, costs, side effects, and brachytherapy template-guided three-dimensional mapping biopsies (3DMB) for tumor localization will also be explored.

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1126 Role of Polymorphisms in the ERCC2 Gene in the Development of Severe Side Effects After Radiotherapy of Prostate Cancer Patients

European Journal of Cancer ◽

10.1016/s0959-8049(12)71727-6 ◽

2012 ◽

Vol 48 ◽

pp. S271

Author(s):

E.M. Thurner ◽

S. Krenn-Pilko ◽

W. Renner ◽

J. Szkandera ◽

A. Gerger ◽

...

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Cancer Patients

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Role of Focal Therapy with High-Intensity Focused Ultrasound in the Management of Clinically Localized Prostate Cancer

Oncology Research and Treatment ◽

10.1159/000441600 ◽

2015 ◽

Vol 38 (12) ◽

pp. 634-638 ◽

Cited By ~ 9

Author(s):

Timur H. Kuru ◽

Julius van Essen ◽

David Pfister ◽

Daniel Porres

Keyword(s):

Prostate Cancer ◽

High Intensity ◽

Focused Ultrasound ◽

Focal Therapy ◽

High Intensity Focused Ultrasound ◽

Localized Prostate Cancer

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The prevalence of the Neglected Sexual Side Effects (NSSEs) after early prostate cancer treatment and the role of a questionnaire in its diagnosis: A Scoping Review Protocol

10.21203/rs.3.rs-27667/v1 ◽

2020 ◽

Author(s):

Pierre Roscher ◽

Jacqueline M Van Wyk

Keyword(s):

Prostate Cancer ◽

Side Effects ◽

Research Question ◽

Eligibility Criteria ◽

Treatment Interventions ◽

Early Prostate Cancer ◽

Sexual Side Effects ◽

Review Team ◽

Review Protocol

Abstract Background: Early prostate cancer (PCa) treatment interventions may leave men with debilitating sexual side effects. These side effects may remain permanent, often undiagnosed and undermanaged. The objective of this study is to map the evidence pertaining to the prevalence, and use of questionnaires, related to the neglected sexual side effects (NSSE) after Pca treatment.Methods:This systematic scoping review’s search strategy will involve the following electronic databases: PubMed, Science Direct and Google Scholar. Following title searching, two-independent reviewers will conduct screening of abstracts and full articles. Thescreenings will be guided by the eligibility criteria. Data will be extracted from the included studies and the emerging themes will be analysed. The review team will analyse the implications of the findings in relation to the research question and aim of the study. The Mixed Method Appraisal Tool (MMAT) will be employed for quality appraisal of included studies.Discussion: We anticipate finding a small amount of studies pertaining to the prevalence and questionnaire use for NSSE after early PCa treatment. The study findings will be disseminated through publication in a peer-reviewed journal, peer presentations as well as presentations at relevant conferences

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MP78-10 A COMPARISON OF CANCER CONTROL OUTCOMES AT 5 YEARS OF FOCAL THERAPY (USING HIFU & CRYOTHERAPY) TO RADICAL PROSTATECTOMY FOR CLINICALLY SIGNIFICANT NON-METASTATIC PROSTATE CANCER: PROPENSITY SCORE-MATCHED ANALYSIS

The Journal of Urology ◽

10.1097/01.ju.0000557342.09456.94 ◽

2019 ◽

Vol 201 (Supplement 4) ◽

Author(s):

Taimur T. Shah ◽

Max Peters ◽

Deepika Reddy* ◽

Daniel Ball ◽

Annie Kim ◽

...

Keyword(s):

Prostate Cancer ◽

Radical Prostatectomy ◽

Propensity Score ◽

Metastatic Prostate Cancer ◽

Cancer Control ◽

Focal Therapy ◽

Clinically Significant

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Robotic-Assisted Laparoscopic Radical Prostatectomy: An Objective Assessment and Review of the Literature

The Scientific World JOURNAL ◽

10.1100/tsw.2006.400 ◽

2006 ◽

Vol 6 ◽

pp. 2589-2061 ◽

Cited By ~ 1

Author(s):

Lester S. Borden Jr. ◽

Paul M. Kozlowski

Keyword(s):

Prostate Cancer ◽

Radical Prostatectomy ◽

Objective Assessment ◽

Cancer Control ◽

Laparoscopic Radical Prostatectomy ◽

Robotic Assisted ◽

Open Radical Prostatectomy ◽

Term Data

Robotic-assisted laparoscopic radical prostatectomy (RLRP) has become an accepted treatment option for men with prostate cancer. A search of the available literature through January 2006 was performed to analyze the surgical technique, outcomes data, and other unique issues regarding RLRP. While prospective, randomized trials and long-term data are lacking, short-term data from single institution series have demonstrated outcomes for RLRP that appear to be equivalent to those for open radical prostatectomy (ORP). Although not yet proven, some encouraging data suggest that RLRP may be able to achieve improved cancer control, postoperative urinary control, and erectile function compared to open surgery for prostate cancer. Definite advantages of RLRP over ORP are not yet established. Future studies will determine the role of RLRP in the surgical treatment of men with prostate cancer.

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