Basic aspects of sleep–wake disorders

Author(s):  
Gregory Stores

A sound working knowledge of the diagnosis, significance, and treatment of sleep disorders is essential in all branches of clinical psychiatry. Unfortunately, however, psychiatrists and psychologists share with other specialties and disciplines an apparently universal neglect of sleep and its disorders in their training. Surveys in the United States and Europe point to the consistently meagre coverage of these topics in their courses at both undergraduate and postgraduate levels. The following account is an introductory overview of normal sleep, the effects of sleep disturbance, sleep disorders and the risk of failure to recognize them in psychiatric practice, assessment of sleep disturbance, and the various forms of treatment that are available. The aim is to provide a background for the other chapters in this section. The close links between the field of sleep disorders and psychiatry which make it essential that psychiatrists are familiar with the field are as follows: ♦ Sleep disturbance is an almost invariable feature and complication of psychiatric disorders from childhood to old age, with the risk of further reducing the individual's capacity to cope with their difficulties (see Table 4.14.1.3 for further details). ♦ Sleep disturbance can presage psychiatric disorder. ♦ Some psychotropic medications produce significant sleep disturbance. ♦ Of importance to liason psychiatry is the fact that many general medical or paediatric disorders disturb sleep sufficiently to contribute to psychological or psychiatric problems. ♦ Because of lack of familiarity with sleep disorders and their various manifestations, such disorders may well be misinterpreted as primary psychiatric disorders (or, indeed, other clinical conditions) with the result that effective treatments for the sleep disorder are unwittingly withheld (see later). Some of these points will be amplified in later sections of this chapter.

SLEEP ◽  
2021 ◽  
Author(s):  
Jeanne F Duffy ◽  
Sabra M Abbott ◽  
Helen J Burgess ◽  
Stephanie J Crowley ◽  
Jonathan S Emens ◽  
...  

Abstract This White Paper presents the results from a workshop cosponsored by the Sleep Research Society (SRS) and the Society for Research on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians and sleep and circadian rhythm researchers to identify existing gaps in diagnosis and treatment and areas of high-priority research in circadian rhythm sleep–wake disorders (CRSWD). CRSWD are a distinct class of sleep disorders caused by alterations of the circadian time-keeping system, its entrainment mechanisms, or a misalignment of the endogenous circadian rhythm and the external environment. In these disorders, the timing of the primary sleep episode is either earlier or later than desired, irregular from day-to-day, and/or sleep occurs at the wrong circadian time. While there are incomplete and insufficient prevalence data, CRSWD likely affect at least 800,000 and perhaps as many as 3 million individuals in the United States, and if Shift Work Disorder and Jet Lag are included, then many millions more are impacted. The SRS Advocacy Taskforce has identified CRSWD as a class of sleep disorders for which additional high-quality research could have a significant impact to improve patient care. Participants were selected for their expertise and were assigned to one of three working groups: Phase Disorders, Entrainment Disorders, and Other. Each working group presented a summary of the current state of the science for their specific CRSWD area, followed by discussion from all participants. The outcome of those presentations and discussions are presented here.


Author(s):  
Rebecca Marshall ◽  
Kyle P. Johnson ◽  
Anna Ivanenko

This chapter reviews pediatric sleep–wake disorders, with a particular focus on evaluation and treatment of sleep disturbances comorbid with primary psychiatric disorders and commonly prevalent primary sleep disorders in the pediatric population. The sleep disturbances due to primary sleep disorders can often result in symptoms and behaviors suggestive of a psychiatric condition such as inattention, poor impulse control, academic impairment, mood changes, fatigue, and excessive daytime sleepiness. It is important that the pediatric clinician assesses the youth presenting with sleep and psychiatric symptomatology for presence of primary sleep disorders. Consultation with a sleep physician for further evaluation and treatment is recommended if a primary sleep disorder is suspected. More evidence-based treatments are needed for primary insomnia and sleep disturbances comorbid with primary psychiatric disorders in pediatric population.


2020 ◽  
Vol 21 (19) ◽  
pp. 7244
Author(s):  
Elke Humer ◽  
Christoph Pieh ◽  
Georg Brandmayr

Sleep-wake disorders are highly prevalent disorders, which can lead to negative effects on cognitive, emotional and interpersonal functioning, and can cause maladaptive metabolic changes. Recent studies support the notion that metabolic processes correlate with sleep. The study of metabolite biomarkers (metabolomics) in a large-scale manner offers unique opportunities to provide insights into the pathology of diseases by revealing alterations in metabolic pathways. This review aims to summarize the status of metabolomic analyses-based knowledge on sleep disorders and to present knowledge in understanding the metabolic role of sleep in psychiatric disorders. Overall, findings suggest that sleep-wake disorders lead to pronounced alterations in specific metabolic pathways, which might contribute to the association of sleep disorders with other psychiatric disorders and medical conditions. These alterations are mainly related to changes in the metabolism of branched-chain amino acids, as well as glucose and lipid metabolism. In insomnia, alterations in branched-chain amino acid and glucose metabolism were shown among studies. In obstructive sleep apnea, biomarkers related to lipid metabolism seem to be of special importance. Future studies are needed to examine severity, subtypes and treatment of sleep-wake disorders in the context of metabolite levels.


‘Management of Sleep Disorders in Psychiatry’ provides an in-depth and evidence-based review of sleep-wake disorders included in Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) that are associated with a range of psychiatric disorders including mood, anxiety, psychotic, neurocognitive, eating, and substance use disorders. It also includes special sections on sleep-wake disorders associated with pediatric and neurological disorders, and reviews forensic issues encountered in the practice of psychiatry as they relate to sleep disorders. The book is unique in its focus on clinical assessment and management of sleep-wake disorders, and provides in-depth insight into the impact of disturbed sleep and wakefulness on clinical course and treatment outcomes of comorbid psychiatric conditions. Treatments reviewed include both evidence-based pharmacological and behavioral strategies to address sleep-wake disorders in patients with psychiatric disorders. Case vignettes are added to assist in the understanding of key clinical concepts of sleep and psychiatric comorbidity and multiple-choice questions are added for self-assessment. This comprehensive text aims to cater to the needs of the clinicians in a wide range of medical specialties including psychiatrists, sleep medicine physicians, psychologists, primary care physicians, and neurologists who strive to improve the sleep and clinical outcomes of their patients with psychiatric disorders.


Author(s):  
David Semple ◽  
Roger Smyth

Covering sleep research, normal sleep, and then sleep–wake disorders, this chapter splits abnormal sleep into insomnia, hypersomnia, circadian rhythm disorders, and parasomnias. Individual cases, such as sleep-related epilepsy, panic attacks, and sleep-related violence, are all defined. The effects of psychiatric medication on sleep (either sedative or alerting) are defined, as well as the effects of recreational drugs. The intersection of other psychiatric disorders on the sleep schedule are described, and potential differential diagnoses listed.


2019 ◽  
Vol 15 (1) ◽  
pp. 33-36
Author(s):  
Animesh Gupta ◽  
Soumya K. Inamadar ◽  
Ashish Goel

Geriatric syndromes consist of common clinical conditions affecting the elderly population. They lead to multiple, interacting medical and social deficits that increase the risk of adverse health outcomes, including dependence, institutionalization and also death. Research over the last few decades, in this area of medicine, has led to evolution of newer syndromes that pose a greater challenge to the physician. The present review aims to provide a synopsis of some of the newer syndromes like frailty, osteosarcopenia, sleep disorders and oropharyngeal dysphagia that have emerged in geriatric literature in recent times.


2021 ◽  
Vol 9 (2) ◽  
pp. 31
Author(s):  
Christine E. Mc Carthy

Sleep complaints can be both common and complex in the older patient. Their consideration is an important aspect of holistic care, and may have an impact on quality of life, mortality, falls and disease risk. Sleep assessment should form part of the comprehensive geriatric assessment. If sleep disturbance is brought to light, consideration of sleep disorders, co-morbidity and medication management should form part of a multifaceted approach. Appreciation of the bi-directional relationship and complex interplay between co-morbidity and sleep in older patients is an important element of patient care. This article provides a brief overview of sleep disturbance and sleep disorders in older patients, in addition to their association with specific co-morbidities including depression, heart failure, respiratory disorders, gastro-oesophageal reflux disease, nocturia, pain, Parkinson’s disease, dementia, polypharmacy and falls. A potential systematic multidomain approach to assessment and management is outlined, with an emphasis on non-pharmacological treatment where possible.


1995 ◽  
Vol 7 (2) ◽  
pp. 181-194
Author(s):  
G. Vernon Pegram ◽  
Ed Lucas
Keyword(s):  

2017 ◽  
Vol 52 (7) ◽  
pp. 837-846
Author(s):  
Leopoldo J. Cabassa ◽  
Roberto Lewis-Fernández ◽  
Shuai Wang ◽  
Carlos Blanco

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