scholarly journals Possible periodic activity in the repeating FRB 121102

2020 ◽  
Vol 495 (4) ◽  
pp. 3551-3558 ◽  
Author(s):  
K M Rajwade ◽  
M B Mickaliger ◽  
B W Stappers ◽  
V Morello ◽  
D Agarwal ◽  
...  
Keyword(s):  
Large Range ◽  
Radio Bursts ◽  
Periodic Activity ◽  
Radio Monitoring ◽  
Periodic Behaviour ◽  
Long Term Monitoring ◽  
Term Monitoring ◽  
High Cadence

ABSTRACT The discovery that at least some Fast Radio Bursts (FRBs) repeat has ruled out cataclysmic events as the progenitors of these particular bursts. FRB 121102 is the most well-studied repeating FRB but despite extensive monitoring of the source, no underlying pattern in the repetition has previously been identified. Here, we present the results from a radio monitoring campaign of FRB 121102 using the 76 m Lovell telescope. Using the pulses detected in the Lovell data along with pulses from the literature, we report a detection of periodic behaviour of the source over the span of 5 yr of data. We predict that the source is currently ‘off’ and that it should turn ‘on’ for the approximate MJD range 59002−59089 (2020 June 2 to 2020 August 28). This result, along with the recent detection of periodicity from another repeating FRB, highlights the need for long-term monitoring of repeating FRBs at a high cadence. Using simulations, we show that one needs at least 100 h of telescope time to follow-up repeating FRBs at a cadence of 0.5–3 d to detect periodicities in the range of 10–150 d. If the period is real, it shows that repeating FRBs can have a large range in their activity periods that might be difficult to reconcile with neutron star precession models.

scholarly journals Outcome in surgically treated Rathke's cleft cysts: long-term monitoring needed

2011 ◽  
Vol 165 (1) ◽  
pp. 33-37 ◽  
Author(s):  
R Trifanescu ◽  
V Stavrinides ◽  
P Plaha ◽  
S Cudlip ◽  
J V Byrne ◽  
...  
Keyword(s):  
Visual Field ◽  
Visual Field Defects ◽  
Rathke's Cleft Cysts ◽  
Long Term Monitoring ◽  
Rathke's Cleft ◽  
Term Monitoring ◽  
Field Defects ◽  
Tsh Deficiency

ObjectiveTo clarify the outcome of all cases of Rathke's cleft cysts (RCC) treated surgically and followed up in Oxford during a long-term period.Subjects and methodsThe records of all patients with RCC seen in the Department of Endocrinology between January 1978 and June 2009 were reviewed.ResultsA total of 33 patients (20 females, median age 43 years) were identified. At presentation, major visual field defects were detected in 58% of patients and gonadotrophin, ACTH and TSH deficiency in 60, 36 and 36% of patients respectively. Desmopressin treatment was required in 18% of patients. Treatment consisted of cyst evacuation combined with or without biopsy/removal of the wall. Post-operatively, visual fields improved in 83% of patients with impairment, whereas there was no reversal of ACTH or TSH deficiency or of diabetes insipidus. All but one subject had imaging follow-up during a mean period of 48 months (range 2–267). Cyst relapse was detected in 22% of patients at a mean interval of 29 months (range 3–48 months); in 57% of them, the recurrence was symptomatic. Relapse-free rates were 88% at 24-months and 52% at 48-months follow-up. At last assessment, at least quadrantanopia was reported in 19% of patients, gonadotrophin, ACTH and TSH deficiency in 50, 42 and 47% of patients respectively. Desmopressin treatment was required in 39% of patients.ConclusionsIn this study of patients with RCC and long-term follow-up, we showed a considerable relapse rate necessitating long-term monitoring. Surgical intervention is of major importance for the restoration of visual field defects, but it does not improve endocrine morbidity, which in the long-term affects a substantial number of patients.

Long-Term Monitoring of Tricyclic Antidepressant Plasma Concentrations

1980 ◽  
Vol 137 (5) ◽  
pp. 444-451 ◽  
Author(s):  
Agrégé Henry Loo ◽  
Kader Benyacoub ◽  
Vincenzo Rovei ◽  
Carlo A. Altamura ◽  
Marthe Vadrot ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Side Effects ◽  
Plasma Concentrations ◽  
Antidepressant Drugs ◽  
Tricyclic Antidepressant ◽  
Self Medication ◽  
Long Term Monitoring ◽  
Term Monitoring

SummaryPlasma levels of antidepressant drugs were measured in 17 depressed patients at roughly monthly intervals over follow-up periods of three to 26 months. Good results in seven were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome. Such fluctuations were probably from poor compliance or drug interaction from self-medication. Severe side effects and cardiotoxicity were associated with high levels.

scholarly journals Best Practices for Long-Term Monitoring and Follow-Up of Alemtuzumab-Treated MS Patients in Real-World Clinical Settings

2019 ◽  
Vol 10 ◽  
Author(s):  
Krista Barclay ◽  
Robert Carruthers ◽  
Anthony Traboulsee ◽  
Ann D. Bass ◽  
Christopher LaGanke ◽  
...  
Keyword(s):  
Best Practices ◽  
Real World ◽  
Clinical Settings ◽  
Long Term Monitoring ◽  
Term Monitoring

scholarly journals Long-term monitoring of sulfonamides and tetracyclines in manure amended soils and leachate samples - A follow-up study

Heliyon ◽  
2020 ◽  
Vol 6 (8) ◽  
pp. e04656
Author(s):  
Astrid Spielmeyer ◽  
Madeleine S. Petri ◽  
Heinrich Höper ◽  
Gerd Hamscher
Keyword(s):  
Amended Soils ◽  
Follow Up Study ◽  
Long Term Monitoring ◽  
Term Monitoring

scholarly journals Undetectable Sensitive Serum Thyroglobulin (<0.1 ng/ml) in 163 Patients with Follicular Cell-Derived Thyroid Cancer: Results of rhTSH Stimulation and Neck Ultrasonography and Long-Term Biochemical and Clinical Follow-Up

2012 ◽  
Vol 97 (8) ◽  
pp. 2714-2723 ◽  
Author(s):  
A. M. Chindris ◽  
N. N. Diehl ◽  
J. E. Crook ◽  
V. Fatourechi ◽  
R. C. Smallridge
Keyword(s):  
Thyroid Cancer ◽  
Radioactive Iodine ◽  
Stage Iv ◽  
Needle Aspiration ◽  
Serum Thyroglobulin ◽  
Iodine Treatment ◽  
Long Term Monitoring ◽  
Term Monitoring

Abstract Context: Surveillance of patients with differentiated thyroid cancer (DTC) is achieved using serum thyroglobulin (Tg), neck ultrasonography (US), and recombinant human TSH (rhTSH)-stimulated Tg (Tg-stim). Objective: Our primary aim was to assess the utility of rhTSH Tg-stim in patients with suppressed Tg (Tg-supp) below 0.1 ng/ml using a sensitive assay. Our secondary aims were to assess the utility of US and to summarize the profile of subsequent Tg-supp measures. Design: This is a retrospective study conducted at two sites of an academic institution. Patients: A total of 163 patients status after thyroidectomy and radioactive iodine treatment who had Tg-supp below 0.1 ng/ml and rhTSH Tg-stim within 60 d of each other were included. Results: After rhTSH stimulation, Tg remained below 0.1 ng/ml in 94 (58%) and increased to 0.1–0.5 in 56 (34%), more than 0.5–2.0 in nine (6%), and above 2.0 ng/ml in four (2%) patients. Serial Tg-supp levels were obtained in 138 patients followed over a median of 3.6 yr. Neck US were performed on 153 patients; suspicious exams had fine-needle aspiration (FNA). All positive FNA were identified around the time of the initial rhTSH test. Six of seven recurrences were detected by US (Tg-stim &gt;2.0 ng/ml in one, 0.8 in one and ≤0.5 in four). One stage IV patient had undetectable Tg-stim. Conclusion: In patients with DTC whose T4-suppressed serum Tg is below 0.1 ng/ml, long-term monitoring with annual Tg-supp and periodic neck US are adequate to detect recurrences. In our experience, rhTSH testing does not change management and is not needed in this group of patients.

scholarly journals Long-term monitoring of arrhythmias in cardiac sarcoidosis

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Bakker ◽  
H Mathijssen ◽  
J Balt ◽  
V.F Van Dijk ◽  
M Veltkamp ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Risk Stratification ◽  
Cardiac Death ◽  
Cardiac Sarcoidosis ◽  
Low Risk ◽  
Risk Patients ◽  
Long Term Monitoring ◽  
Term Monitoring

Abstract Introduction Screening for cardiac sarcoidosis (CS) is recommended since it can manifest with ventricular arrhythmias (VA), atrioventricular conduction block (AVB) and sudden cardiac death (SCD). However, risk stratification for SCD is challenging, in particular in patients without overt cardiac symptoms. Purpose This study reports the practice-based risk stratification for SCD and the incidence of arrhythmias and mortality in CS patients by long-term monitoring of arrhythmias. Methods A retrospective, single center cohort study was performed in 537 patients with sarcoidosis screened for cardiac involvement with cardiac MRI and fluorodeoxyglucose PET in an hospital, a Dutch tertiary referral center. CS was diagnosed in 115 of 537 patients (21%), complete follow up was available in 108 patients (94%). After risk assessment for SCD (figure 1) an ICD was implanted in 16 high-risk patients. Within the92 low-risk patients, 80 had an internal loop recorder (ILR) implanted and 12 patients received no device. Chart review was performed to assess the occurrence of VA, AVB, death, ICD therapy and device related complications. Results During a mean follow-up of 31±15 months, 9 out of 80 ILR patients (11.3%) received an ICD of whom 7 (8.8%) based on recorded arrhythmias (VA in 5 and AVB in 2 patients). Five out of the total 25 ICD patients (20%) experienced sustained VA successfully treated with anti-tachycardia pacing in 2 (8%) and terminated spontaneously in all other patients. Two ICD patients experienced a mild pocket infection, treated with antibiotics. Two deaths occurred in the low-risk patients: 1 non-cardiac death and 1 SCD due to asystole. Conclusion The practice-based risk stratification supported an ICD implantation in up to 5% of sarcoidosis patients screened for CS. Sustained VA occurred in 20% of ICD patients.Early detection of important arrhythmias with an ILR can optimize risk assessment for SCD in CS. Practise-based risk stratification Funding Acknowledgement Type of funding source: None

scholarly journals Pemantauan trauma kepala pada anak

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jufitriani Ismy
Keyword(s):  
Early Childhood ◽  
Head Injury ◽  
Head Trauma ◽  
Head Injuries ◽  
Developmental Abnormalities ◽  
Key Words Head Trauma ◽  
Long Term Monitoring ◽  
Term Monitoring

Abstrak. Trauma kepala pada pada anak dapat terjadi akibat pukulan, jatuh,  benturan maupun hentakan mendadak. Trauma kepala ringan salah satu kasus tersering di bagian neurologi anak. Trauma kepala dapat menyebabkan cedera kepala dan penyebab kematian terbanyak pada anak.  Perbedaan dari segi anatomi, fisiologi, serta metabolisme pada anak dan dewasa sehingga pada anak lebih mudah untuk mengalami  cedera kepala dibandingkan dengan orang dewasa.  Pemantauan saat terjadinya trauma dan pemantauan jangka panjang diperlukan untuk mendeteksi secara dini kelainan perkembangan anak.Kata kunci: Trauma kepala anak, cedera kepala, pemantauan  Abstract. Head trauma in children can occur due to blows, falls, collisions or sudden shocks. Mild head trauma is one of the most common cases in pediatric neurology. Head trauma can cause head injuries and is the leading cause of death in children. Differences in terms of anatomy, physiology, and metabolism in children and adults make it easier for children to experience head injuries than adults. Monitoring when trauma occurs and long-term monitoring is needed to detect early childhood developmental abnormalities. Key words: head trauma in children,  head injury, follow up

Long-Term Monitoring of Cancer-Free Subjects Carrying Non-Lymphoma Associated bcl2/IgH Rearrangements (NLABR): Prolonged Persistence of Clonal Populations Potentially Related to Follicular Lymphoma (FL).

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 1373-1373
Author(s):  
Marco Ladetto ◽  
Barbara Mantoan ◽  
Federica De Marco ◽  
Berardino Pollio ◽  
Daniela Drandi ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Real Time ◽  
Median Time ◽  
Real Time Pcr ◽  
Direct Sequencing ◽  
Two Samples ◽  
Long Term Monitoring ◽  
Term Monitoring

Abstract Introduction: NLABRs are frequently observed in cancer free-subjects. We recently observed that NLABR-positive clones can persist up to 60 days (Ladetto et al, J Clin Oncol 2003). However the long-term kinetics and potential pre-neoplastic role of NLABR-carrying cells are unknown. To define the natural history of NLABR-positive clones, long term monitoring of cancer-free subjects carrying these lesions has been performed. Methods: 118 subjects undergoing periodical blood examinations for warfarin therapy were screened for the bcl-2/IgH translocation. PCR-positive subjects underwent subsequent monitoring at least once every three months. NLABR-positive clones were monitored using both nested and real time-PCR according to previously published approaches (Ladetto et al Exp Hematol 2001). Sequence homology of NLABRs has always been confirmed by direct sequencing of nested PCR products. Results: 15 NLABR-positive subjects were identified out of 118 (12.7%) subjects. NLABR-positive subjects were monitored for a median time of 13 months (mos) (range 3–30 mos) for a total number of 60 timepoints. In eight subjects (53%), NLABRs detected at study initiation were not detected again in follow-up samples. These eight subjects have been monitored for median period of 12 mos (range 3–28 mos). Follow-up samples in this group were usually PCR-negative, although transient PCR-positivity due to unrelated NLABRs were noticed in two samples. In seven subjects (47%), the same NLABR observed at study initiation was detected one or more times at follow-up. In four subjects, NLABRs detected at diagnosis were amplified in every available follow-up sample (three to seven samples were available for each subject). In three, NLABRs detected at diagnosis were amplified only in a fraction of follow-up samples while the remaining were PCR-negative. Overall, persistent NLABRs were followed on these subjects for a median time of 15 months (range 3–30). The median burden of persistent NLABRs assessed by real-time PCR was 33 rearrangements (rg)/106 diploid genomes (dg) (range <10–760), while the median burden of short-lived NLABRs was <10rg/106 dg (range <10–330). The number of NLABR-positive cells appeared to be rather stable in subjects with persistent NLABR-positive clones. In none of these subjects we could detect differences greater than 1 log among available follow-up samples. Subjects having mixed PCR-positive and PCR-negative results had a smaller tumor burden compared to those constantly PCR-positive. This is consistent with the presence of a small though persistent clonal population. Studies on selected populations showed that NLABR-positive cells were CD19-positive. Discussion: NLABR-positive clones are long-lived cell populations in approximately 50% of cases. Based on this finding it is reasonable to hypothesize the existence of a follicular lymphoma (FL)-related lymphoproliferation of undetermined significance. Since NLABRs occurs in more than than 10% of healthy subjects, this condition is expected to be highly prevalent in the general population (as observed in MGUS and CLUS) and of potential relevance for the pathogenesis of FL.

scholarly journals Supraventricular Runs in 7-Day Holter Monitoring Are Related to Increased Incidence of Atrial Fibrillation in a 3-Year Follow-Up of Cryptogenic Stroke Patients Free from Arrhythmia in a 24 h-Holter

2021 ◽  
Vol 8 (7) ◽  
pp. 81
Author(s):  
Andrzej Kułach ◽  
Milena Dewerenda ◽  
Michał Majewski ◽  
Anetta Lasek-Bal ◽  
Zbigniew Gąsior
Keyword(s):  
Atrial Fibrillation ◽  
Cryptogenic Stroke ◽  
Holter Monitoring ◽  
Ecg Monitoring ◽  
Stroke Patients ◽  
Long Term Monitoring ◽  
In Cis ◽  
Term Monitoring

Introduction: Silent atrial fibrillation (AF) is a common cause of cryptogenic ischemic stroke (CIS). The 24-h-Holter is insufficient to reveal an occult arrhythmic cause of stroke and the strategy to select the patients for long-term monitoring is missing. Objectives: The aim of the study was to evaluate 7-day-Holter monitoring to identify cases with the arrhythmic cause of stroke in CIS patients in whom 24-h-Holter was free from arrhythmia, and to assess the relation between supraventricular (SV) runs in baseline Holter and the incidence of AF in a 3-year follow-up period. Methods: 78 patients (aged 60 ± 9 years, 45 males) with CIS and no arrhythmic findings in 24-h-Holter were enrolled. All patients had 7-day-Holter monitoring after stroke and were followed up for 36 months, and then 7-day Holter was repeated. We assessed SV runs (≥5 QRS) in the initial 7-day Holter and analyzed the relation of the findings with clinical characteristics of novel AF episodes revealed early after stroke and during a 3-year follow-up. Results: Baseline 7-day-Holter revealed SV runs in 36% of patients and AF in 9% of cases. During a 3-year follow-up, 8 additional cases were confirmed, both in standard care and in repeated Holter (a total of 19% of AF cases). There was no difference with regard to CHADS2VASc score (3.6 ± 1.1 vs. 3.4 ± 1.5; p = NS) and left atrium parameters between patients with SV runs and the non-arrhythmic group. Patients with SV runs had a higher incidence of AF both after stroke and in a 3-year follow-up (46% vs. 4%, RR 11.6, p < 0.001). In 8 cases, patent foramen ovale was detected during follow-up. Conclusions: A strategy of baseline 7-day-Holter monitoring after stroke allows for disclosing SV runs in every third case and AF in 9% of stroke survivors. Patients with SV runs have a higher incidence of AF (RR 11.6, p < 0.001) and should be considered for extended continuous ECG monitoring.

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