scholarly journals Long-term FRII jet evolution in dense environments

Author(s):  
Manel Perucho ◽  
José-María Martí ◽  
Vicent Quilis

Abstract We present long-term numerical three-dimensional simulations of a relativistic outflow propagating through a galactic ambient medium and environment, up to distances ∼100 kpc. Our aim is to study the role of dense media in the global dynamics of the radio source. We use a relativistic gas equation of state, and a basic description of thermal cooling terms. In previous work, we showed that a linear perturbation could enhance the jet propagation during the early phases of evolution, by introducing obliquity to the jet reverse shock. Here, we show that this effect is reduced in denser media. We find that the dentist-drill effect acts earlier, due to slower jet propagation and an increased growth of the helical instability. The global morphology of the jet is less elongated, with more prominent lobes. The fundamental physical parameters of the jet generated structure derived from our simulations fall within the estimated values derived for FRII jets in the 3C sample. In agreement with previous axisymmetric and three dimensional simulations in lower density media, we conclude that shock heating of the interstellar and intergalactic media is very efficient in the case of powerful, relativistic jets.

Over most of each active region in nematic and chiral nematic twist cells the motion and configuration of the liquid crystal layer does not vary appreciably with position parallel to the surfaces. In such laminar regions the statics, dynamics and optics ot the cell can be accurately simulated at low cost on a computer of moderate size, given the appropriate physical parameters. Methods and recent advances in simulation of laminar regions are reviewed. Bistable twist cells are simulated for illustration. Important problems of stability and edge effects in the presence of electric fields await solution with two- or three-dimensional simulations.


2020 ◽  
Vol 499 (2) ◽  
pp. 2051-2062 ◽  
Author(s):  
R Bandiera ◽  
N Bucciantini ◽  
J Martín ◽  
B Olmi ◽  
D F Torres

ABSTRACT The standard approach to the long-term evolution of pulsar wind nebulae (PWNe) is based on one-zone models treating the nebula as a uniform system. In particular for the late phase of evolved systems, many of the generally used prescriptions are based on educated guesses for which a proper assessment lacks. Using an advanced radiative code, we evaluate the systematic impact of various parameters, like the properties of the supernova ejecta, of the inner pulsar, as well of the ambient medium, upon the extent of the reverberation phase of PWNe. We investigate how different prescriptions shift the starting time of the reverberation phase, how this affects the amount of the compression, and how much of this can be ascribable to the radiation processes. Some critical aspects are the description of the reverse shock evolution, the efficiency by which at later times material from the ejecta accretes on to the swept-up shell around the PWN, and finally the density, velocity, and pressure profiles in the surrounding supernova remnant. We have explicitly treated the cases of the Crab Nebula, and of J1834.9−0846, taken to be representatives of the more and the less energetic pulsars, respectively. Especially for the latter object, the prediction of large compression factors is confirmed, even larger in the presence of radiative losses, also confirming our former prediction of periods of superefficiency during the reverberation phase of some PWNe.


Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 675 ◽  
Author(s):  
Yi Zhao ◽  
Ranjith Kankala ◽  
Shi-Bin Wang ◽  
Ai-Zheng Chen

With advantageous features such as minimizing the cost, time, and sample size requirements, organ-on-a-chip (OOC) systems have garnered enormous interest from researchers for their ability for real-time monitoring of physical parameters by mimicking the in vivo microenvironment and the precise responses of xenobiotics, i.e., drug efficacy and toxicity over conventional two-dimensional (2D) and three-dimensional (3D) cell cultures, as well as animal models. Recent advancements of OOC systems have evidenced the fabrication of ‘multi-organ-on-chip’ (MOC) models, which connect separated organ chambers together to resemble an ideal pharmacokinetic and pharmacodynamic (PK-PD) model for monitoring the complex interactions between multiple organs and the resultant dynamic responses of multiple organs to pharmaceutical compounds. Numerous varieties of MOC systems have been proposed, mainly focusing on the construction of these multi-organ models, while there are only few studies on how to realize continual, automated, and stable testing, which still remains a significant challenge in the development process of MOCs. Herein, this review emphasizes the recent advancements in realizing long-term testing of MOCs to promote their capability for real-time monitoring of multi-organ interactions and chronic cellular reactions more accurately and steadily over the available chip models. Efforts in this field are still ongoing for better performance in the assessment of preclinical attributes for a new chemical entity. Further, we give a brief overview on the various biomedical applications of long-term testing in MOCs, including several proposed applications and their potential utilization in the future. Finally, we summarize with perspectives.


2018 ◽  
Vol 482 (3) ◽  
pp. 3718-3735 ◽  
Author(s):  
Manel Perucho ◽  
José-María Martí ◽  
Vicent Quilis

Author(s):  
C.L. Woodcock

Despite the potential of the technique, electron tomography has yet to be widely used by biologists. This is in part related to the rather daunting list of equipment and expertise that are required. Thanks to continuing advances in theory and instrumentation, tomography is now more feasible for the non-specialist. One barrier that has essentially disappeared is the expense of computational resources. In view of this progress, it is time to give more attention to practical issues that need to be considered when embarking on a tomographic project. The following recommendations and comments are derived from experience gained during two long-term collaborative projects.Tomographic reconstruction results in a three dimensional description of an individual EM specimen, most commonly a section, and is therefore applicable to problems in which ultrastructural details within the thickness of the specimen are obscured in single micrographs. Information that can be recovered using tomography includes the 3D shape of particles, and the arrangement and dispostion of overlapping fibrous and membranous structures.


2020 ◽  
Vol 36 (06) ◽  
pp. 696-702
Author(s):  
Nolan B. Seim ◽  
Enver Ozer ◽  
Sasha Valentin ◽  
Amit Agrawal ◽  
Mead VanPutten ◽  
...  

AbstractResection and reconstruction of midface involve complex ablative and reconstructive tools in head and oncology and maxillofacial prosthodontics. This region is extraordinarily important for long-term aesthetic and functional performance. From a reconstructive standpoint, this region has always been known to present challenges to a reconstructive surgeon due to the complex three-dimensional anatomy, the variable defects created, combination of the medical and dental functionalities, and the distance from reliable donor vessels for free tissue transfer. Another challenge one faces is the unique features of each individual resection defect as well as individual patient factors making each preoperative planning session and reconstruction unique. Understanding the long-term effects on speech, swallowing, and vision, one should routinely utilize a multidisciplinary approach to resection and reconstruction, including head and neck reconstructive surgeons, prosthodontists, speech language pathologists, oculoplastic surgeons, dentists, and/or craniofacial teams as indicated and with each practice pattern. With this in mind, we present our planning and reconstructive algorithm in midface reconstruction, including a dedicated focus on dental rehabilitation via custom presurgical planning.


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