scholarly journals Influence of dispersion medium on nanomaterial-induced pulmonary inflammation and DNA strand breaks: investigation of carbon black, carbon nanotubes and three titanium dioxide nanoparticles

Mutagenesis ◽  
2017 ◽  
Vol 32 (6) ◽  
pp. 581-597 ◽  
Author(s):  
Niels Hadrup ◽  
Stefan Bengtson ◽  
Nicklas R Jacobsen ◽  
Petra Jackson ◽  
Marek Nocun ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Titanium Dioxide ◽  
Carbon Black ◽  
Black Carbon ◽  
Dispersion Medium ◽  
Titanium Dioxide Nanoparticles ◽  
Pulmonary Inflammation ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
Dna Strand

Assessment of evidence for nanosized titanium dioxide-generated DNA strand breaks and oxidatively damaged DNA in cells and animal models

2017 ◽  
Vol 11 (9-10) ◽  
pp. 1237-1256 ◽  
Author(s):  
Peter Møller ◽  
Ditte Marie Jensen ◽  
Regitze Sølling Wils ◽  
Maria Helena Guerra Andersen ◽  
Pernille Høgh Danielsen ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Animal Models ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
Nanosized Titanium Dioxide ◽  
Dna Strand ◽  
Assessment Of Evidence ◽  
In Cells ◽  
Damaged Dna

scholarly journals Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

2011 ◽  
Vol 6 (5) ◽  
pp. 486-500 ◽  
Author(s):  
Petra Jackson ◽  
Karin Sørig Hougaard ◽  
Anne Mette Z. Boisen ◽  
Nicklas Raun Jacobsen ◽  
Keld Alstrup Jensen ◽  
...  
Keyword(s):  
Carbon Black ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
Pulmonary Exposure ◽  
Pregnant Mice ◽  
Dna Strand

scholarly journals Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks.

1983 ◽  
Vol 258 (24) ◽  
pp. 15198-15205 ◽  
Author(s):  
W D Henner ◽  
S M Grunberg ◽  
W A Haseltine
Keyword(s):  
Ionizing Radiation ◽  
Dna Strand Breaks ◽  
Strand Breaks ◽  
Enzyme Action ◽  
Radiation Induced ◽  
Dna Strand

scholarly journals Repair of DNA Strand Breaks by the Overlapping Functions of Lesion-Specific and Non-Lesion-Specific DNA 3′ Phosphatases

2001 ◽  
Vol 21 (21) ◽  
pp. 7191-7198 ◽  
Author(s):  
John R. Vance ◽  
Thomas E. Wilson
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Synthetic Lethality ◽  
Dna Strand Breaks ◽  
Triple Mutant ◽  
Phosphatase Domain ◽  
Strand Breaks ◽  
Alternative Pathways ◽  
Processing Enzymes ◽  
Dna Strand

ABSTRACT In Saccharomyces cerevisiae, the apurinic/apyrimidinic (AP) endonucleases Apn1 and Apn2 act as alternative pathways for the removal of various 3′-terminal blocking lesions from DNA strand breaks and in the repair of abasic sites, which both result from oxidative DNA damage. Here we demonstrate that Tpp1, a homologue of the 3′ phosphatase domain of polynucleotide kinase, is a third member of this group of redundant 3′ processing enzymes. Unlike Apn1 and Apn2, Tpp1 is specific for the removal of 3′ phosphates at strand breaks and does not possess more general 3′ phosphodiesterase, exonuclease, or AP endonuclease activities. Deletion ofTPP1 in an apn1 apn2 mutant background dramatically increased the sensitivity of the double mutant to DNA damage caused by H2O2 and bleomycin but not to damage caused by methyl methanesulfonate. The triple mutant was also deficient in the repair of 3′ phosphate lesions left by Tdp1-mediated cleavage of camptothecin-stabilized Top1-DNA covalent complexes. Finally, the tpp1 apn1 apn2 triple mutation displayed synthetic lethality in combination with rad52, possibly implicating postreplication repair in the removal of unrepaired 3′-terminal lesions resulting from endogenous damage. Taken together, these results demonstrate a clear role for the lesion-specific enzyme, Tpp1, in the repair of a subset of DNA strand breaks.

Presence of DNA Strand Breaks and Increased Sensitivity of DNA in Situ to Denaturation in Abnormal Human Sperm Cells: Analogy to Apoptosis of Somatic Cells

1993 ◽  
Vol 207 (1) ◽  
pp. 202-205 ◽  
Author(s):  
Wojciech Gorczyca ◽  
Frank Traganos ◽  
Hanna Jesionowska ◽  
Zbigniew Darzynkiewicz
Keyword(s):  
Somatic Cells ◽  
Human Sperm ◽  
Dna Strand Breaks ◽  
Sperm Cells ◽  
Strand Breaks ◽  
Increased Sensitivity ◽  
Dna Strand

scholarly journals DNA strand breaks in grass shrimp embryos exposed to highway runoff sediments and sediments with coal fly ash

2008 ◽  
Vol 66 (1) ◽  
pp. 164-165 ◽  
Author(s):  
Richard F. Lee ◽  
Luis Felipe H. Niencheski ◽  
Karrie Brinkley
Keyword(s):  
Fly Ash ◽  
Coal Fly Ash ◽  
Grass Shrimp ◽  
Dna Strand Breaks ◽  
Highway Runoff ◽  
Strand Breaks ◽  
Dna Strand
Sign in / Sign up

Export Citation Format

Share Document