scholarly journals Noncoder: a web interface for exon array-based detection of long non-coding RNAs

2012 ◽  
Vol 41 (1) ◽  
pp. e20-e20 ◽  
Author(s):  
Pascal Gellert ◽  
Yuliya Ponomareva ◽  
Thomas Braun ◽  
Shizuka Uchida
Keyword(s):  
Exon Array ◽  
Web Interface ◽  
Non Coding Rnas

scholarly journals Exon Array Analyzer: a web interface for Affymetrix exon array analysis

2009 ◽  
Vol 25 (24) ◽  
pp. 3323-3324 ◽  
Author(s):  
Pascal Gellert ◽  
Shizuka Uchida ◽  
Thomas Braun
Keyword(s):  
Exon Array ◽  
Web Interface ◽  
Array Analysis ◽  
Affymetrix Exon Array

LncR2metasta: a manually curated database for experimentally supported lncRNAs during various cancer metastatic events

2020 ◽  
Author(s):  
Shihua Zhang ◽  
Xiaolong He ◽  
Rui Zhang ◽  
Wensheng Deng
Keyword(s):  
Target Gene ◽  
Detection Method ◽  
Human Cancer ◽  
Pattern Detection ◽  
Web Interface ◽  
Tumor Spread ◽  
Cancer Subtypes ◽  
Genomic Location ◽  
Non Coding Rnas ◽  
Optimized Treatment

Abstract Mounting evidence has shown the involvement of long non-coding RNAs (lncRNAs) during various cancer metastatic events (abbreviated as CMEs, e.g. cancer cell invasion, intravasation, extravasation, proliferation, etc.) that may cooperatively facilitate malignant tumor spread and cause massive patient deaths. The study of lncRNA-CME associations might help understand lncRNA functions in metastasis and present reliable biomarkers for early dissemination detection and optimized treatment. Therefore, we developed a database named ‘lncR2metasta’ by manually compiling experimentally supported lncRNAs during various CMEs from existing studies. LncR2metasta documents 1238 associations between 304 lncRNAs and 39 CMEs across 54 human cancer subtypes. Each entry of lncR2metasta contains detailed information on a lncRNA-CME association, including lncRNA symbol, a specific CME, brief description of the association, lncRNA category, lncRNA Entrez or Ensembl ID, lncRNA genomic location and strand, lncRNA experiment, lncRNA expression pattern, detection method, target gene (or pathway) of lncRNA, lncRNA regulatory role on a CME, cancer name and the literature reference. An easy-to-use web interface was deployed in lncR2metasta for its users to easily browse, search and download as well as to submit novel lncRNA-CME associations. LncR2metasta will be a useful resource in cancer research community. It is freely available at http://lncR2metasta.wchoda.com.

scholarly journals IRNdb: The database of immunologically relevant non-coding RNAs.

2016 ◽  
Author(s):  
Elena Denisenko ◽  
Daniel Ho ◽  
Ousman Tamgue ◽  
Mumin Ozturk ◽  
Harukazu Suzuki ◽  
...  
Keyword(s):  
Immune System ◽  
Target Genes ◽  
Data Repository ◽  
Web Interface ◽  
Control Of Gene Expression ◽  
Gene Annotations ◽  
Non Coding Rnas ◽  
User Friendly ◽  
Immune Target

MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified as a critical regulatory mechanism in the immune system. Despite the great efforts made to discover and characterize ncRNAs, the functional role for most remains unknown. To facilitate discoveries in ncRNA regulation of immune system-related processes we developed the database of immunologically relevant ncRNAs and target genes (IRNdb). We integrated mouse data on predicted and experimentally supported ncRNA-target interactions, ncRNA and gene annotations, biological pathways and processes, and experimental data in a uniform format with a user-friendly web interface. The current version of IRNdb documents 12,930 experimentally supported miRNA-target interactions between 724 miRNAs and 2,427 immune-related murine targets. In addition, we recorded 22,453 lncRNA-immune target and 377 PIWI-interacting RNA-immune target interactions. IRNdb is a comprehensive searchable data repository which will be of help in studying the role of ncRNAs in the immune system. Database URL: http://irndb.org

Long Non-Coding RNAs Are Commonly Deregulated in Hodgkin Lymphoma

2014 ◽  
Vol 226 (02) ◽  
Author(s):  
A van den Berg ◽  
M Tayari ◽  
G Kortman ◽  
J Sietzema ◽  
D de Jong ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Non Coding Rnas

MicroRNAs and their role in hematological malignant diseases

2012 ◽  
Vol 153 (52) ◽  
pp. 2051-2059 ◽  
Author(s):  
Zsuzsanna Gaál ◽  
Éva Oláh
Keyword(s):  
Target Genes ◽  
Lymphoblastic Leukemia ◽  
Cancer Tissue ◽  
Altered Expression ◽  
Diagnosis And Prognosis ◽  
Oncologic Patients ◽  
Different Types ◽  
Non Coding Rnas ◽  
Success Of Treatment ◽  
Posttranscriptional Level

MicroRNAs are a class of small non-coding RNAs regulating gene expression at posttranscriptional level. Their target genes include numerous regulators of cell cycle, cell proliferation as well as apoptosis. Therefore, they are implicated in the initiation and progression of cancer, tissue invasion and metastasis formation as well. MicroRNA profiles supply much information about both the origin and the differentiation state of tumours. MicroRNAs also have a key role during haemopoiesis. An altered expression level of those have often been observed in different types of leukemia. There are successful attempts to apply microRNAs in the diagnosis and prognosis of acute lymphoblastic leukemia and acute myeloid leukemia. Measurement of the expression levels may help to predict the success of treatment with different kinds of chemotherapeutic drugs. MicroRNAs are also regarded as promising therapeutic targets, and can contribute to a more personalized therapeutic approach in haemato-oncologic patients. Orv. Hetil., 2012, 153, 2051–2059.

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