scholarly journals Protective effects of endothelin antagonists in chronic renal failure

1999 ◽  
Vol 14 (suppl 4) ◽  
pp. 29-30 ◽  
Author(s):  
S. Wolf ◽  
B. Brehm ◽  
F. Gaschler ◽  
S. Brehm ◽  
M. Klaussner ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Protective Effects ◽  
Endothelin Antagonists

Elevation Of Antithrombin III By Sulfinpyrazone Therapy In Chronic Renal Failure

1981 ◽  
Author(s):  
M Bern ◽  
J Green
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Antithrombin Iii ◽  
Chronic Hemodialysis ◽  
Protective Effects ◽  
Platelet Factor ◽  
At Iii ◽  
Before And After ◽  
Artery Disease ◽  
And Function

Sulfinpyrazone can reduce the incidence of thrombosis of A-V shunts in chronic renal failure. The drug is also reported to prevent acute deaths from coronary artery disease. This study was to determine mechanisms for these protective effects.Patients on chronic hemodialysis served as the study models. Six patients on dialysis three times per week for 6 or more months received sulfinpyrazone 200 mgm t.i.d. p.o. for 14 days. Blood samples were obtained before dialysis was begun before and after the 14 days of drug therapy.Results are shown as mean ± standard error of mean.AT III levels rose significantly by functional and immune assays. Functional levels (by von Kaulla technique) rose 24.5 ± 3.1 sec. to 47.3 + 5.5 sec. (P>.005) Plasma protein AT III (by radial immunodiffusion) rose 31.2 ± 2.17 mg/dl to 37.9 ± 2.1 mgm/dl. (P>.01) Platelet factor 4 (by Abbot radioimmunology assay) fell from 46.4 + 13.6 ngm/ml to 9.5 ± 1.1 ngm/ml.(P>.005) The concentration of thrombin-anti-thrombin complex (by R. Rosenberg, Harvard Medical School, Boston) rose from 4.2 ± .09 to 8.4 ± 1.0 (P>.005)Thus it appears that sulfinpyrazone elevates antithrombin concentration and function while simultaneously suppressing platelet release. These two effects may or may not be mutually dependent. The clinical efficacy of sulfinpyrazone may relate in part to the elevation of antithrombin III, probably by inhibiting its consumption, while also inhibiting platelet function.

scholarly journals Protective effects of Pai-Du-Yang-Shen formula on chronic renal failure in rats

2019 ◽  
Vol 17 ◽  
pp. 205873921987141
Author(s):  
Ronghua Pan ◽  
Guohua Rui ◽  
Xiaohui Bai ◽  
Zhiyin Teng ◽  
Gang Chen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Transforming Growth Factor ◽  
Smooth Muscle Actin ◽  
Transforming Growth Factor Β ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Protein Levels ◽  
Yang Shen ◽  
Necrosis Factor

This study aimed to elucidate the therapeutic effects of a traditional Chinese medicine, Pai-Du-Yang-Shen (PDYS) Formula, in 5/6 nephrectomy-induced chronic renal failure (CRF). The CRF model was established via 5/6 nephrectomy (Nx) in rats. Then, PDYS (0.9 and 1.8 g/kg/day), or an equal amount of normal saline, was administrated to the rats in respective groups. Our results showed that PDYS treatment improved degeneration, fibrosis, and histopathological abnormalities of renal tissues in 5/6 Nx rats. Furthermore, the increase in serum creatinine (Scr), blood urea nitrogen (BUN), and total urinary protein (TUP) in 5/6 Nx rats was reduced by PDYS treatment. In addition, the levels of tumor necrosis factor (TNF), fibronectin (FN), and laminin (LN) that were induced in 5/6 Nx rats were also decreased by PDYS treatment. Finally, relative mRNA expression of α-smooth muscle actin (α-SMA), FN, transforming growth factor-β (TGF-β), and TNF as well as protein levels of TGF-β, NF-κB p65, and phosphorylated NF-κB p65 (p-p65) in renal tissues correlated with the concentration of TNF. In conclusion, PDYS shows therapeutic effects against CRF as determined by a reduction in markers for inflammation and fibrosis.

scholarly journals Protective Effects of Bu-Shen-Huo-Xue Formula against 5/6 Nephrectomy-Induced Chronic Renal Failure in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Jian-Rao Lu ◽  
Hai-Yan Han ◽  
Jie Chen ◽  
Chong-Xiang Xiong ◽  
Xin-Hua Wang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Mrna Expression ◽  
Renal Tissue ◽  
Control Group ◽  
Sham Operation ◽  
Protective Effects ◽  
Treatment Groups ◽  
Significant Amelioration ◽  
Serious Disease

Chronic renal failure (CRF) is a serious disease related to increasing incidence and prevalence as well as decline in quality of life. Bu-Shen-Huo-Xue formula (BSHX), one of traditional herbal formulations, has been clinically employed to treat CRF for decades, but the mechanisms involved have not been investigated. In the present study, we investigated the effects of BSHX on some closely related parameters in 5/6 nephrectomy CRF rats. Rats with CRF were divided into five groups, namely, one control group, one enalapril group, and three BSHX treatment groups (0.25, 0.5, and 1 g/kg·d). The rats subjected to sham operation were used as a normal control. After eight weeks of treatment, BSHX significantly decreased the levels of Scr and BUN, downregulated the mRNA expression levels of TGF-β1, CTGF, NF-κB, TNF-α, and OPN, upregulated the mRNA expression of PPARγ, and reducedin situexpression of fibronectin and laminins. Histological findings also showed significant amelioration of the damaged renal tissue. BSHX protects 5/6 nephrectomy rats against chronic renal failure probably via regulating the expression of TNF-α, NF-κB, TGF-β1, CTGF, PPARγ, OPN, fibronectin, and laminins and is useful for therapy of CRF.

Renal protective effects of chronic exercise and antihypertensive therapy in hypertensive rats with chronic renal failure

2001 ◽  
Vol 19 (10) ◽  
pp. 1877-1882 ◽  
Author(s):  
Masahiro Kohzuki ◽  
Masahiro Kamimoto ◽  
Xue-Min Wu ◽  
Hong-Lan Xu ◽  
Takaguki Kawamura ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Antihypertensive Therapy ◽  
Protective Effects ◽  
Chronic Exercise ◽  
Hypertensive Rats

Abstract 1690: Prevention of Contrast-Induced Nephropathy by Carperitide

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Shuji Morikawa ◽  
Takahito Sone ◽  
Hideyuki Tsuboi ◽  
Hiroaki Mukawa ◽  
Itsuro Morishima ◽  
...  
Keyword(s):  
Renal Failure ◽  
Multivariate Analysis ◽  
Chronic Renal Failure ◽  
Coronary Angiography ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Control Group ◽  
Protective Effects ◽  
Common Complication ◽  
Contrast Induced Nephropathy

Introduction: Contrast-induced nephropathy (CIN) remains as a common complication of angiographic procedure. Carperitide, an antagonist of secretion of rennin, aldosterone and vasopressin with natriuretic effects, has renal protective effects. Hypothesis: Carperitide may be effective in preventing CIN. Methods: We prospectively studied 170 consecutive patients with chronic renal failure (serum creatinine(SCr) concentration >1.3mg/dl)who underwent coronary angiography. The patients were randomly assigned to either 1.3ml/kg/hr of lactated Ringer’s infusion plus carperitide 0.042μg/kg/min (Carperitide group N=86) or lactated Ringer’s infusion alone (Control group N=84). The administration was initiated 6 hours prior to the procedure and continued for 48 hours after angiography. The concentration of SCr and cystatin C were measured at baseline, 24 hours, 48 hours, 1 week, and 1 month following the angiography. Results: The SCr concentration increased gradually up to one month in the Control group, whereas remained almost unchanged in the Carperitide group (p=0.001 for the trend, Figure ). The cystatin C concentration also showed the same trend (p=0.013 for the trend, Figure ). When CIN was defined as an increase of ≥0.5 mg/dl or ≥25% in the SCr at 48 hours after angiography, CIN developed in 7 of 84 patients (8%) in the Control group and 1 of 86 patients (1%) in the Carperitide group (P=0.047). Multivariate analysis disclosed that carperitide infusion (OR 0.097, P=0.041) and quantity of contrast media (OR 14.06, P=0.004) were significantly related to the development of CIN. Conclusions: Carperitide is effective in preventing CIN in patients with chronic renal failure.

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