scholarly journals P1730KIDNEY PAIRED DONATION IN SLOVAKIA - TOWARDS TO THE NATIONALLY COORDINATED PROGRAMME

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Tatiana Baltesova ◽  
Luboslav Bena ◽  
Eva Lacková ◽  
Ivana Dedinska ◽  
Magdalena Krátka ◽  
...  
Keyword(s):  
Married Couples ◽  
National Registry ◽  
Living Kidney Donation ◽  
Cold Ischemia ◽  
Donor Kidney ◽  
Compatible Pair ◽  
Kidney Exchange ◽  
Kidney Transplantations ◽  
Eu Project ◽  
Exchange Programmes

Abstract Background and Aims AB0 and HLA incompatibility between donor and recipient is one of the possible reasons of the low rate of living kidney donation in Slovakia. Method We present a retrospective analysis of living donor kidney transplantations (LDKT) in Slovakia including kidney paired donations. Results During the period from 2015 to 2019 there were 823 kidney transplantations, 81 (9,8%) were from living donors. Kidney paired donations are performed since 2005. Altogether 8 two-way paired exchanges were done in 3 transplant centers. The first exchange between two centers was carried out in 2015. A majority of the involved pairs (81%) were married couples, one exchange was initiated by compatible pair. Surgical procedures were simultaneous, cold ischemia times were comparable to other LDKT (median 162 vs 182 minutes). Two recipients had early acute rejection, 3-year graft survival is 100%. There were no serious complications in donors. The participation in EU project ENCKEP (European Network for Collaboration on Kidney Exchange Programmes) has led to the creation of national registry of incompatible pairs in 2018 and the standardization of medical and legal processes of paired exchanges. Conclusion Above reported experience is adequate prerequisite for the launch of nationally coordinated programme and international cooperation.

scholarly journals Kidney Exchange and the Ethics of Giving

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Philippe Van Basshuysen
Keyword(s):  
End Stage Renal Disease ◽  
Moral Obligation ◽  
Donor Kidney ◽  
Ethical Concerns ◽  
Kidney Exchange ◽  
Live Donor Kidney ◽  
Stage Renal Disease ◽  
End Stage ◽  
Exchange Programmes

The best treatment for end-stage renal disease is the transplantation of a live donor kidney, but many people cannot donate to their loved ones because they are incompatible. Kidney exchange promises relief. Kidney exchange programmes use centralised procedures to match donors with recipients in a way that maximises the quantity and quality of transplants. However, the transplant laws in many countries render kidney exchange programmes impossible because of ethical concerns against these programmes or against kinds of kidney donations on which these programmes rely. I give two novel arguments for the implementation of kidney exchange programmes. The first is that they are instrumental in meeting a moral obligation, namely to donate effectively. The second is that they may increase the motivation for altruistic donations, because the donation of one kidney may trigger >1 life savings. Moreover, ethical concerns are considered that are embodied in transplant laws preventing the implementation of kidney exchange, and it is argued that they can be overcome.

scholarly journals Logistical Factors Influencing Cold Ischemia Times in Deceased Donor Kidney Transplants

2016 ◽  
Vol 100 (2) ◽  
pp. 422-428 ◽  
Author(s):  
Sussie Shrestha ◽  
Lisa Bradbury ◽  
Matthew Boal ◽  
James P. Blackmur ◽  
Christopher J. E. Watson ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Kidney Transplants ◽  
Cold Ischemia ◽  
Donor Kidney ◽  
Factors Influencing ◽  
Deceased Donor Kidney

Temporal trends in living kidney donation in France between 2007 and 2017

2019 ◽  
Author(s):  
François Gaillard ◽  
Lola Jacquemont ◽  
Veena Roberts ◽  
Laetitia Albano ◽  
Julien Allard ◽  
...  
Keyword(s):  
Temporal Trends ◽  
National Registry ◽  
The Body ◽  
Kidney Donation ◽  
Risk Indicator ◽  
Living Kidney Donation ◽  
No Donor ◽  
Living Kidney Donors ◽  
Increased Risk

Abstract Background Long-term studies have demonstrated a slight increased risk for end-stage renal disease (ESRD) for living kidney donors (LKD). In France, living kidney donation doubled within the past 10 years. We investigated the change in characteristics of LKD between 2007 and 2017 and the adequacy of follow-up. Methods Data were obtained from the national registry for LKD. We compared characteristics of LKD between two study periods: 2007–11 and 2012–17, and stratified donors by age and relation to recipient. We aggregated four characteristics associated with higher ESRD risk [young age, first-degree relation to recipient, obesity, low glomerular filtration rate (GFR) for age] in a single risk indicator ranging from 0 to 4. Results We included 3483 donors. The proportion of unrelated donors >56 years of age increased significantly. The proportion of related donors <56 years of age decreased significantly. The body mass index and proportion of obese donors did not change significantly. The proportion of donors with low estimated GFR for age decreased significantly from 5% to 2.2% (P < 0.001). The proportion of donors with adequate follow-up after donation increased from 19.6% to 42.5% (P < 0.001). No donor had a risk indicator equal to 4, and the proportion of donors with a risk indicator equal to 0 increased significantly from 19.2% to 24.9% (P < 0.001). Conclusions An increase in living kidney donation in France does not seem to be associated with the selection of donors at higher risk of ESRD and the proportion of donors with adequate annual follow-up significantly increased.

scholarly journals IP solutions for international kidney exchange programmes

2020 ◽  
Author(s):  
Radu-Stefan Mincu ◽  
Péter Biró ◽  
Márton Gyetvai ◽  
Alexandru Popa ◽  
Utkarsh Verma
Keyword(s):  
Kidney Exchange ◽  
Exchange Programmes

scholarly journals Élődonoros vesecsereprogramok Európában. Hol tart Magyarország? Összefoglaló tanulmány az ENCKEP (European Network for Collaboration on Kidney Exchange Programmes) COST Action eddigi eredményei alapján

2018 ◽  
Vol 159 (46) ◽  
pp. 1905-1912 ◽  
Author(s):  
Péter Biró ◽  
Ádám Remport ◽  
Sándor Mihály ◽  
Lóránt Illésy ◽  
Balázs Nemes
Keyword(s):  
Lessons Learned ◽  
Successful Operation ◽  
Cost Action ◽  
Kidney Exchange ◽  
The United Kingdom ◽  
Ethical And Legal Issues ◽  
Exchange Programme ◽  
Stage Renal Disease ◽  
End Stage ◽  
Exchange Programmes

Abstract: Patients with end-stage renal disease may exchange their willing, but incompatible donors among each other in centrally coordinated kidney exchange programmes. The aim of this writing is to summarise the results of the ENCKEP COST Action, and describe the lessons learned with regard to the plans for the Hungarian kidney exchange programme. The ENCKEP COST Action had several workshops since 2016 September, and its first working group conducted two surveys that they summarised in two handbooks; our description is based on these resources. There are already 10 national kidney exchange programmes in Europe, the oldest is in the Netherlands (operating since 2004) and the largest in the United Kingdom, where already more than 700 patients received a kidney through this programme in the last ten years. There are a number of countries with plans to start a kidney exchange programme, and international collaborations are also getting established in several regions. Kidney exchange programmes can significantly increase the opportunities of the kidney patients for getting living donor transplants, but for the successful operation of a kidney exchange programme the organisers have to resolve several medical, logistic, optimisation, ethical and legal issues. Orv Hetil. 2018; 159(46): 1905–1912.

scholarly journals Beliefs of UK Transplant Recipients about Living Kidney Donation and Transplantation: Findings from a Multicentre Questionnaire-Based Case–Control Study

2019 ◽  
Vol 9 (1) ◽  
pp. 31 ◽  
Author(s):  
Pippa K. Bailey ◽  
Fergus J. Caskey ◽  
Stephanie MacNeill ◽  
Charles Tomson ◽  
Frank J. M. F. Dor ◽  
...  
Keyword(s):  
Case Control Study ◽  
Deceased Donor ◽  
Case Control ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Psychosocial Effects ◽  
Donor Kidney ◽  
The United Kingdom ◽  
Deceased Donor Kidney Transplant ◽  
Control Study

Differing beliefs about the acceptability of living-donor kidney transplants (LDKTs) have been proposed as explaining age, ethnic and socioeconomic disparities in their uptake. We investigated whether certain patient groups hold beliefs incompatible with LDKTs. This questionnaire-based case–control study was based at 14 hospitals in the United Kingdom. Participants were adults transplanted between 1 April 2013 and 31 March 2017. LDKT recipients were compared to deceased-donor kidney transplant (DDKT) recipients. Beliefs were determined by the direction and strength of agreement with ten statements. Multivariable logistic regression was used to investigate the association between beliefs and LDKT versus DDKT. Sex, age, ethnicity, religion, and education were investigated as predictors of beliefs. A total of 1240 questionnaires were returned (40% response). DDKT and LDKT recipients responded in the same direction for 9/10 statements. A greater strength of agreement with statements concerning the ‘positive psychosocial effects’ of living kidney donation predicted having an LDKT over a DDKT. Older age, Black, Asian and Minority Ethnic (BAME) group ethnicity, and having a religion other than Christianity were associated with greater degree of uncertainty regarding a number of statements, but there was no evidence that individuals in these groups hold strong beliefs against living kidney donation and transplantation. Interventions should address uncertainty, to increase LDKT activity in these groups.

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