scholarly journals Longitudinal follow-up of bone mineral density in children with nephrotic syndrome and the role of calcium and vitamin D supplements

2005 ◽  
Vol 20 (8) ◽  
pp. 1598-1603 ◽  
Author(s):  
Sanjeev Gulati ◽  
Raj K. Sharma ◽  
Kiran Gulati ◽  
Uttam Singh ◽  
Arvind Srivastava
2013 ◽  
Vol 24 (10) ◽  
pp. 2571-2579 ◽  
Author(s):  
S. M. H. Alibhai ◽  
H. Z. Mohamedali ◽  
H. Gulamhusein ◽  
A. H. Panju ◽  
H. Breunis ◽  
...  

2019 ◽  
Vol 49 (4) ◽  
pp. 292-298
Author(s):  
Indar K Sharawat ◽  
Lesa Dawman ◽  
Merabhai V Kumkhaniya ◽  
Kusum Devpura ◽  
Amarjeet Mehta

Glucocorticoids are first-line therapy for children with idiopathic nephrotic syndrome (INS). These children are at risk of deranged bone metabolism and low bone mineral density (BMD). We studied 60 children with INS and divided them into two groups. Group 1 included 21 children (initial and infrequent relapsing) and group 2 included 39 children (frequent relapsing, steroid dependent and steroid resistant). Dual-energy X-ray absorptiometry of the lumbar spine was performed to assess BMD. Mean BMD Z-score was compared in both groups; this correlated significantly on univariate analysis with cumulative steroid dose, serum vitamin D levels and calcium supplementation. However, on multivariate analysis, serum vitamin D level was the only factor significantly predictive of low z-score.


Nephrology ◽  
2016 ◽  
Vol 21 (6) ◽  
pp. 483-489 ◽  
Author(s):  
Abhinav Aggarwal ◽  
Ashok K Yadav ◽  
Raja Ramachandran ◽  
Vinod Kumar ◽  
Vivek Kumar ◽  
...  

2017 ◽  
Vol 158 (32) ◽  
pp. 1252-1258 ◽  
Author(s):  
Szilvia Szamosi ◽  
Ágnes Horváth ◽  
Zoltán Szekanecz ◽  
Gabriella Szűcs

Abstract: In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is prevalent in several autoimmune diseases, including systemic sclerosis. Hypovitaminosis has been found to be associated with low bone mineral density and higher prevalence of osteoporosis in this group of patients. Determinants of low bone density in SSc are poorly understood. Studies have shown the importance of both traditional osteoporotic as well as disease-specific factors (extent of skin involvement, presence of internal organ manifestation, malabsorption, systemic sclerosis subtype, serological profile, medication) in the development of low bone mineral density. The relationship between low bone density in systemic sclerosis patients and the above mentioned risk factors may be more complex and the real role of each factor is unclear. Yet very few studies reported clinically relevant low bone mass outcomes such as fracture risk assessment and fracture associated mortality in scleroderma. This review aims to synthesize data about the essential role of vitamin D in immune homeostasis as well as the prevalence of hypovitaminosis, low bone density, changes in bone turnover markers and presence of osteoporosis in scleroderma patients. Orv Hetil. 2017; 158(32): 1252–1258.


2016 ◽  
Vol 26 (5) ◽  
pp. 1141-1145 ◽  
Author(s):  
Mustafa Raoof ◽  
Ingmar Näslund ◽  
Eva Rask ◽  
Eva Szabo

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