scholarly journals Is tacrolimus for childhood steroid-dependent nephrotic syndrome better than ciclosporin A?

2006 ◽  
Vol 21 (7) ◽  
pp. 1761-1763 ◽  
Author(s):  
Jörg Dötsch ◽  
Katalin Dittrich ◽  
Christian Plank ◽  
Wolfgang Rascher
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Dependent ◽  
Ciclosporin A ◽  
Steroid Dependent Nephrotic Syndrome ◽  
Better Than

scholarly journals Cyclophosphamide in frequent-relapsing or steroid-dependent nephrotic syndrome: Review of 38 patients

2016 ◽  
Vol 45 (1) ◽  
pp. 18
Author(s):  
Yulia Iriani ◽  
Taralan Tambunan ◽  
Sudigdo Sastroasmoro
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclophosphamide Therapy ◽  
Steroid Dependent ◽  
Steroid Sensitive Nephrotic Syndrome ◽  
Steroid Sensitive ◽  
The Mean ◽  
One Year ◽  
Steroid Dependent Nephrotic Syndrome ◽  
Better Than

Background Steroid-sensitive nephrotic syndrome (SSNS) in chil-dren is characterized by relapsing courses in a substantial propor-tion of affected individuals. Children with frequent-relapsing neph-rotic syndrome (FRNS) or steroid-dependent nephrotic syndrome(SDNS) are at risk of severe steroid toxicity and need individual-ized treatment. Previous studies have elucidated that cyclophos-phamide (CPA) reduced the risk of relapses and increased thelength of subsequent remissions in children with relapsing SSNS.Methods This retrospective study evaluated 38 patients (26 FRNSand 12 SDNS) after cyclophosphamide therapy to elucidate theefficacy of CPA in FRNS or SDNS in the Department of Child Health,Cipto Mangunkusumo Hospital. All patients were treated with CPA(2 mg/kg per day) for 8 weeks, in combination with prednisone.Results The median (range) duration of follow up was 45 months(24-140 months) for FRNS and 29 months (24-63 months) forSDNS. The mean relapse rate one year prior to CPA therapy inFRNS and SDNS were 3.8 relapses/year (95%CI 3.4; 4.2) and 4.0relapses/year (95%CI 3.3; 4.7), which were reduced to 1.6 relapses/year (95% CI 1.1; 2.1) and 2.3 relapses/year (95%CI 1.5;3.2), re-spectively. The overall rate of cumulative sustained good response(complete remission or infrequent relapses) was 65% after 36months. Frequent relapsing versus steroid-dependent status wassignificantly correlated with rate of sustained good response after36 months (85% versus 15%) with OR=23 (95%CI 3.1;225.2).Conclusion The efficacy of cyclophosphamide therapy in themanagement of FRNS is better than in SDNS

A case of a 7-year-old boy with steroid-dependent nephrotic syndrome who developed severe neutropenia three months after the administration of rituximab

2009 ◽  
Vol 22 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Ryugo Hiramoto ◽  
Shinsuke Matsumoto ◽  
Hironobu Eguchi ◽  
Yoshitaka Miyoshi ◽  
Isao Komori ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Severe Neutropenia ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Short-term efficacy of rituximab versus tacrolimus in steroid-dependent nephrotic syndrome

2011 ◽  
Vol 27 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Aditi Sinha ◽  
Arvind Bagga ◽  
Ashima Gulati ◽  
Pankaj Hari
Keyword(s):  
Nephrotic Syndrome ◽  
Short Term ◽  
Term Efficacy ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Mycophenolate sodium for children with frequently relapsing or steroid dependent nephrotic syndrome

2017 ◽  
Vol 54 (10) ◽  
pp. 885-886
Author(s):  
Kanika Kapoor ◽  
Abhijeet Saha ◽  
Manpreet Kaur ◽  
Nand Kishore Dubey ◽  
Ashish Datt Upadhyay
Keyword(s):  
Nephrotic Syndrome ◽  
Mycophenolate Sodium ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

scholarly journals The Efficacy and Safety of Rituximab for Childhood Steroid-Dependent Nephrotic Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Sidi Liu ◽  
Chuying Gui ◽  
Zhenzhen Lu ◽  
Huijie Li ◽  
Zhike Fu ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Randomized Clinical Trials ◽  
Remission Rate ◽  
Cochrane Library ◽  
Control Group ◽  
Efficacy And Safety ◽  
Steroid Dependent ◽  
Alternative Treatment Option ◽  
Control Study ◽  
Steroid Dependent Nephrotic Syndrome

Objectives: Rituximab (RTX), a possible alternative treatment option, is recognized as a new therapeutic hope for the treatment of steroid-dependent nephrotic syndrome (SDNS) in children. However, the efficacy and safety of RTX in the treatment of childhood SDNS are still controversial. The objective of this study was to evaluate the efficacy and safety of RTX treatment in children with SDNS.Study Design: Six randomized controlled trials (RCTs) and one retrospective comparative control study data from studies, performed before January 2021 were collected, from PubMed, Cochrane Library, Embase, and Web of Science. The studies evaluating the efficacy and safety of RTX in childhood SDNS were included.Results: Six RCTs and one retrospective comparative control study were included in our analysis. Compared with the control group, the RTX treatment group achieved a higher complete remission rate (OR = 5.21; 95% CI, 3.18–8.54; p < 0.00001), and we found significant differences between the two groups on serum albumin level (MD = 0.88; 95% CI, 0.43–1.33; p = 0.0001) and estimated glomerular filtration rate (MD = 6.43; 95% CI, 2.68–10.19; p = 0.0008). However, RTX treatment did not significantly lower serum creatinine levels nor did it significantly reduce the occurrence of proteinuria. In addition, we found no advantages with RTX on treatment safety.Conclusions: RTX has shown satisfactory characteristics in terms of efficacy and may be a promising treatment method for SDNS in children. However, the long-term effects have not been fully evaluated and should be further studied through randomized clinical trials.

scholarly journals A case report on usage of rituximab on complicated steroid-dependent nephrotic syndrome

2020 ◽  
Vol 10 (1) ◽  
pp. 130
Author(s):  
Shravan Jayachandran ◽  
S. Suwitha ◽  
A. Priya ◽  
K. Arun Chander
Keyword(s):  
Nephrotic Syndrome ◽  
Treatment Duration ◽  
Supportive Treatment ◽  
Childhood Disease ◽  
Steroid Dependent ◽  
The Status ◽  
Resistance Patterns ◽  
History Of ◽  
The Common ◽  
Steroid Dependent Nephrotic Syndrome

Nephrotic syndrome (NS) is one of the common yet challenging childhood disease. Treating NS with immunosuppressants like corticosteroids is typically effective. However, there are significant evidences which displayed resistance patterns to the former drugs. Here in this case, a male patient came to the nephrology department with the history of steroid dependant nephrotic syndrome with complaint of its infrequent relapse. The condition was complicated since, the patient was on multiple steroids even after which there were recurrent episodes of syndrome. Considering the status, Mycophenolate mofetil was added as a supportive treatment for the management of the disease along with steroids, still the outcome was unremarkable. Hence, rituximab was ordered (four cycles). The outcome this time was appreciable, rituximab administration produced a positive result. No events were recorded during the treatment duration. 

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