scholarly journals Time-course morphological and functional disorders of the kidney induced by long-term high-fat diet intake in female rats

2013 ◽  
Vol 28 (10) ◽  
pp. 2464-2476 ◽  
Author(s):  
C. S. Pinhal ◽  
A. Lopes ◽  
D. B. Torres ◽  
S. L. Felisbino ◽  
J. A. Rocha Gontijo ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Time Course ◽  
Female Rats ◽  
Functional Disorders ◽  
High Fat ◽  
Diet Intake

scholarly journals Effect of long-term high-fat diet intake on peripheral insulin sensibility, blood pressure, and renal function in female rats

2016 ◽  
Vol 60 (1) ◽  
pp. 28536 ◽  
Author(s):  
Noemi A. V. Roza ◽  
Luiz F. Possignolo ◽  
Adrianne C. Palanch ◽  
José A. R. Gontijo
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
High Fat Diet ◽  
Female Rats ◽  
High Fat ◽  
Diet Intake

scholarly journals Long-term High-fat-diet Feeding Impairs Mitochondrial Biogenesis in Liver of Male and Female Rats

2010 ◽  
Vol 26 (3) ◽  
pp. 291-302 ◽  
Author(s):  
Antònia Nadal-Casellas ◽  
Emilia Amengual-Cladera ◽  
Ana María Proenza ◽  
Isabel Lladó ◽  
Magdalena Gianotti
Keyword(s):  
Mitochondrial Biogenesis ◽  
High Fat Diet ◽  
Female Rats ◽  
High Fat ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Intermittent High‐Fat Diet Intake Reduces Sensitivity to Intragastric Nutrient Infusion and Exogenous Amylin in Female Rats

Obesity ◽  
2020 ◽  
Vol 28 (5) ◽  
pp. 942-952 ◽  
Author(s):  
Calyn B. Maske ◽  
Isabel I. Coiduras ◽  
Zeleen E. Ondriezek ◽  
Sarah J. Terrill ◽  
Diana L. Williams
Keyword(s):  
High Fat Diet ◽  
Female Rats ◽  
High Fat ◽  
Diet Intake ◽  
Nutrient Infusion

Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner

2021 ◽  
Author(s):  
Sara Pereira Silva ◽  
José Ivo Araújo Beserra-Filho ◽  
Melina Chiemi Kubota ◽  
Gabriela Nascimento Cardoso ◽  
Francisca Rayanne Silva Freitas ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
High Fat Diet ◽  
Female Rats ◽  
Dependent Manner ◽  
High Fat ◽  
Emotional Aspects ◽  
Diet Intake ◽  
Cycle Dependent

scholarly journals Impact of long-term high-fat diet intake gestational protein-restricted offspring on kidney morphology and function

2016 ◽  
Vol 8 (1) ◽  
pp. 89-100 ◽  
Author(s):  
V. H. G. Rizzi ◽  
L. d. B. Sene ◽  
C. D. B. Fernandez ◽  
J. A. R. Gontijo ◽  
P. A. Boer
Keyword(s):  
Blood Pressure ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Urinary Sodium Excretion ◽  
Tubular Dysfunction ◽  
Functional Disorders ◽  
High Fat ◽  
Urine Ph ◽  
Kidney Morphology

Emerging evidence highlights the far-reaching consequences of high-fat diet (HFD) and obesity on kidney morphological and functional disorders. In the present study, we aim to evaluate the effects of early HFD intake on renal function and morphology in maternal protein-restricted offspring (LP). LP and normal protein-intake offspring (NP) were fed HFD (LPH and NPH, respectively) or standard rodent (LPN and NPN) diet from the 8th to 13th week of age. Blood pressure, kidney function, immunohistochemistry and scanning electron microscopy were analyzed. Increased total cholesterol and low-density lipoprotein serum levels were observed in LPH offspring. The adiposity index was reduced in the (LPN) group and, conversely, increased in the NPH and LPH groups. Blood pressure was higher beyond the 10th week of age in the LPH group compared with the other groups. Decreased urinary sodium excretion was observed in LP offspring, whereas the HFD-treated groups presented a decreased urine pH in a time-dependent fashion. The LPN, NPH and LPH groups showed increased expression of type 1 angiotensin II (AngII) receptor (AT1R), TGF-β1, collagen and fibronectin in the kidneys. Moreover, the adult fetal-programmed offspring showed pronounced effacement of the podocyte foot process associated with the rupture of cell membranes and striking urinary protein excretion, exacerbated by HFD treatment. To the best of our knowledge, this is the first study demonstrating that young fetal-programmed offspring submitted to long-term HFD intake have increased susceptibility to renal structural and functional disorders associated with an accentuated stage of fibrosis and tubular dysfunction.

Time course of insulin resistance associated with feeding dogs a high-fat diet

1997 ◽  
Vol 272 (1) ◽  
pp. E147-E154 ◽  
Author(s):  
A. P. Rocchini ◽  
P. Marker ◽  
T. Cervenka
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Glucose Uptake ◽  
Dose Response ◽  
High Fat Diet ◽  
Time Course ◽  
Rapid Development ◽  
Diet Group ◽  
Whole Body ◽  
High Fat

The current study evaluated both the time course of insulin resistance associated with feeding dogs a high-fat diet and the relationship between the development of insulin resistance and the increase in blood pressure that also occurs. Twelve adult mongrel dogs were chronically instrumented and randomly assigned to either a control diet group (n = 4) or a high-fat diet group (n = 8). Insulin resistance was assessed by a weekly, single-dose (2 mU.kg-1.min-1) euglycemic-hyperinsulinemic clamp on all dogs. Feeding dogs a high-fat diet was associated with a 3.7 +/- 0.5 kg increase in body weight, a 20 +/- 4 mmHg increase in mean blood pressure, a reduction in insulin-mediated glucose uptake [(in mumol-kg-1.min-1) decreasing from 72 +/- 6 before to 49 +/- 7 at 1 wk, 29 +/- 3 at 3 wk, and 30 +/- 2 at 6 wk of the high-fat diet, P < 0.01]. and a reduced insulin-mediated increase in cardiac output. In eight dogs (4 high fat and 4 control), the dose-response relationship of insulin-induced glucose uptake also was studied. The whole body glucose uptake dose-response curve was shifted to the right, and the rate of maximal whole body glucose uptake was significantly decreased (P < 0.001). Finally, we observed a direct relationship between the high-fat diet-induced weekly increase in mean arterial pressure and the degree to which insulin resistance developed. In summary, the current study documents that feeding dogs a high-fat diet causes the rapid development of insulin resistance that is the result of both a reduced sensitivity and a reduced responsiveness to insulin.

The beneficial effects of Lactobacillus fermented black barley on high fat diet-induced fatty liver in rats

2021 ◽  
Author(s):  
Qi Guan ◽  
Xinwen Ding ◽  
Lingyue Zhong ◽  
Chuang Zhu ◽  
Pan Nie ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Beneficial Effects ◽  
Phytochemical Composition

Long term high-fat diet (HF) can cause metabolic disorders, which might induce fatty liver. Fermented whole cereal food exhibit healthy potential due to their unique phytochemical composition and probiotics. In...

scholarly journals A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome–Intestine–Pancreas Axis

2021 ◽  
Vol 22 (4) ◽  
pp. 1647
Author(s):  
Brandi Miller ◽  
Rabina Mainali ◽  
Ravinder Nagpal ◽  
Hariom Yadav
Keyword(s):  
High Fat Diet ◽  
Microbiota Composition ◽  
Preventive Strategies ◽  
Human Origin ◽  
High Fat ◽  
Diabetes In Mice ◽  
Diabetes Progression ◽  
Gut Microbiota Composition

The prevalence of type 2 diabetes mellitus (T2D) is increasing worldwide, and there are no long-term preventive strategies to stop this growth. Emerging research shows that perturbations in the gut microbiome significantly contribute to the development of T2D, while microbiome modulators may be beneficial for T2D prevention. However, microbiome modulators that are effective, safe, affordable, and able to be administered daily are not yet available. Based on our previous pro- and prebiotic studies, we developed a novel synbiotic yogurt comprised of human-origin probiotics and plant-based prebiotics and investigated its impact on diet- and streptozotocin-induced T2D in mice. We compared the effects of our synbiotic yogurt to those of a commercially available yogurt (control yogurt). Interestingly, we found that the feeding of the synbiotic yogurt significantly reduced the development of hyperglycemia (diabetes) in response to high-fat diet feeding and streptozotocin compared to milk-fed controls. Surprisingly, the control yogurt exacerbated diabetes progression. Synbiotic yogurt beneficially modulated the gut microbiota composition compared to milk, while the control yogurt negatively modulated it by significantly increasing the abundance of detrimental bacteria such as Proteobacteria and Enterobacteriaceae. In addition, the synbiotic yogurt protected pancreatic islet morphology compared to the milk control, while the control yogurt demonstrated worse effects on islets. These results suggest that our newly developed synbiotic yogurt protects against diabetes in mice and can be used as a therapeutic to prevent diabetes progression.

Long-term High Fat Diet Consumption Reversibly Alters Feeding Behavior via a Dopamine-Associated Mechanism in Mice

2021 ◽  
pp. 113470
Author(s):  
Everett Altherr ◽  
Aundrea Rainwater ◽  
Darian Kaviani ◽  
Qijun Tang ◽  
Ali D. Güler
Keyword(s):  
Feeding Behavior ◽  
High Fat Diet ◽  
High Fat

High Fat Diet Mediates Amyloid-β Cleaving Enzyme 1 Phosphorylation and SUMOylation, Enhancing Cognitive Impairment in APP/PS1 Mice

2021 ◽  
pp. 1-14
Author(s):  
Jian Bao ◽  
Zheng Liang ◽  
Xiaokang Gong ◽  
Jing Yu ◽  
Yifan Xiao ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
High Fat Diet ◽  
Amyloid Β ◽  
Normal Diet ◽  
Standard Diet ◽  
High Fat ◽  
Augmented Learning ◽  
Biochemical Analyses ◽  
Modifiable Lifestyle Factors

Background: Alzheimer’s disease (AD) is the most common form of dementia in older adults and extracellular accumulation of amyloid-β (Aβ) is one of the two characterized pathologies of AD. Obesity is significantly associated with AD developing factors. Several studies have reported that high fat diet (HFD) influenced Aβ accumulation and cognitive performance during AD pathology. However, the underlying neurobiological mechanisms have not yet been elucidated. Objective: The objective of this study was to explore the underlying neurobiological mechanisms of HFD influenced Aβ accumulation and cognitive performance during AD pathology. Methods: 2.5-month-old male APP/PS1 mice were randomly separated into two groups: 1) the normal diet (ND) group, fed a standard diet (10 kcal%fat); and 2) the HFD group, fed a high fat diet (40 kcal%fat, D12492; Research Diets). After 4 months of HFD or ND feeding, mice in the two groups were subjected for further ethological, morphological, and biochemical analyses. Results: A long-term HFD diet significantly increased perirenal fat and impaired dendritic integrity and aggravated neurodegeneration, and augmented learning and memory deficits in APP/PS1 mice. Furthermore, the HFD increased beta amyloid cleaving enzyme 1 (BACE1) dephosphorylation and SUMOylation, resulting in enhanced enzyme activity and stability, which exacerbated the deposition of amyloid plaques. Conclusion: Our study demonstrates that long-term HFD consumption aggravates amyloid-β accumulation and cognitive impairments, and that modifiable lifestyle factors, such as obesity, can induce BACE1 post-modifications which may contribute to AD pathogenesis.

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