BIOM-09. MYO-INOSITOL LEVELS ON MR SPECTROSCOPY CAN PREDICT FAILURE OF ANTI-ANGIOGENIC TREATMENT IN RECURRENT GLIOBLASTOMA

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi11-vi12
Author(s):  
Mohamed El-Abtah ◽  
Michael Wenke ◽  
Pratik Talati ◽  
Melanie Fu ◽  
Daniel Kim ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Recurrent Glioblastoma ◽  
Term Survival ◽  
Prospective Longitudinal Study ◽  
Normal Appearing White Matter ◽  
Echo Time ◽  
Short Echo Time ◽  
Prospective Longitudinal ◽  
The Brain ◽  
Glial Marker

Abstract BACKGROUND Recurrent glioblastoma (rGBM) patients are often treated with anti-angiogenic agents such as bevacizumab (BEV). Despite therapeutic promise, conventional MR methods fail to determine which patients may not benefit. PURPOSE: The purpose of this study was to utilize magnetic resonance spectroscopic imaging (MRSI) with intermediate and short echo time to generate corrected Myo-inositol normalized by contralateral creatine (mI/c-Cr) in patients with rGBM treated with BEV and investigate whether it can predict survivorship prior to BEV initiation (baseline) and at 1-day, 4-weeks, and 8-weeks thereafter. METHODS We conducted a prospective, longitudinal study and evaluated spectroscopic data of myo-inositol (mI), a glial marker and osmoregulator within the brain, normalized to contralateral-creatine (mI/c-Cr) in the intratumoral, contralateral normal appearing white matter, and peritumoral volumes of rGBM patients. Area under the ROC curve (AUC) was calculated for all volumes at baseline, 1-day, 4-weeks, and 8-weeks after treatment to determine mI/c-Cr’s ability to predict survivorship. RESULTS 21 participants (62 ± 12 years, 15 men) were evaluated. Lower mI/c-Cr in the tumor prior to and during BEV treatment predicted poor survivorship, with ROC analyses illustrating an AUC of 0.75 at baseline, 0.87 at 1-day, and 1 at 8 weeks. Lower levels of mI/c-Cr were also observed in the contralateral and the peritumoral volumes for shorter-term survivors. In the contralateral volume, lower mI/Cr was predictive of shorter-term survival at baseline and all other timepoints. Within the peritumoral volume, lower mI/c-Cr was predictive of shorter-term survival at baseline (AUC=0.80), 1-day (AUC=0.93), and 4-weeks (AUC=0.68). CONCLUSIONS Lower levels of mI/c-Cr within intratumoral, contralateral, and peritumoral volumes were predictive of poor survivorship and anti-angiogenic treatment failure as early as one month before BEV treatment. Acquiring MRSI alongside conventional MR imaging modalities can convey critical information regarding tumor microenvironment that informs management of patients with rGBM.

scholarly journals Airway Telomere Length in Lung Transplant Recipients

2021 ◽  
Vol 12 ◽  
Author(s):  
John A. Mackintosh ◽  
Stephanie T. Yerkovich ◽  
Maxine E. Tan ◽  
Luke Samson ◽  
Peter MA Hopkins ◽  
...  
Keyword(s):  
Telomere Length ◽  
Lung Transplant ◽  
Smoking History ◽  
Donor Age ◽  
Term Survival ◽  
Prospective Longitudinal Study ◽  
All Cause Mortality ◽  
Lung Transplant Recipients ◽  
Prospective Longitudinal ◽  
Airway Cells

IntroductionChronic lung allograft dysfunction (CLAD) represents the major impediment to long term survival following lung transplantation. Donor and recipient telomere length have been shown to associate with lung transplant outcomes, including CLAD. In this study we aimed to measure the telomere lengths of bronchial and bronchiolar airway cells in lung allografts early after transplantation and to investigate associations with CLAD and all-cause mortality.MethodsThis prospective, longitudinal study was performed at The Prince Charles Hospital, Australia. Airway cells were collected via bronchial and bronchiolar airway brushings at post-transplant bronchoscopies. The relative telomere length in airway cells was determined by quantitative PCR based on the T/S ratio. All patients were censored for CLAD and all-cause mortality in August 2020.ResultsIn total 231 bronchoscopies incorporating transbronchial brush and bronchial brush were performed in 120 patients. At the time of censoring, 43% and 35% of patients, respectively, had developed CLAD and had died. Airway bronchiolar and bronchial telomere lengths were strongly correlated (r=0.78, p<0.001), confirming conservation of telomere length with airway branch generation. Both the bronchiolar (r = -0.34, p<0.001) and bronchial (r = -0.31, p<0.001) telomere length decreased with age. Shorter airway telomere length was associated with older donor age and higher donor pack-year smoking history. Neither the bronchiolar nor the bronchial airway telomere length were associated with the development of CLAD (HR 0.39 (0.06-2.3), p=0.30; HR 0.66 (0.2-1.7), p=0.39, respectively) or all-cause mortality (HR 0.92 (0.2-4.5), p=0.92; HR 0.47 (0.1-1.9), p=0.28, respectively).ConclusionsIn this cohort, airway telomere length was associated with donor age and smoking history but was not associated with the future development of CLAD or all-cause mortality.

MRI of the brain with ultra-short echo-time pulse sequences

2003 ◽  
Vol 45 (12) ◽  
pp. 887-892 ◽  
Author(s):  
A. Waldman ◽  
J. H. Rees ◽  
C. S. Brock ◽  
M. D. Robson ◽  
P. D. Gatehouse ◽  
...  
Keyword(s):  
Pulse Sequences ◽  
Echo Time ◽  
Short Echo Time ◽  
The Brain ◽  
Time Pulse

scholarly journals Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 138-139
Author(s):  
Robert Mankowski ◽  
Stephen Anton ◽  
Gabriela Ghita ◽  
Christiaan Leeuwenburgh ◽  
Lyle Moldawer ◽  
...  
Keyword(s):  
Performance Status ◽  
Middle Aged ◽  
Term Survival ◽  
Prospective Longitudinal Study ◽  
Discharge Disposition ◽  
Sepsis Survivors ◽  
Persistent Disability ◽  
Prospective Longitudinal

Abstract As in-hospital sepsis mortality has decreased, more “sepsis survivors” are progressing into poorly characterized long-term outcomes. The purpose of this study was to describe the current epidemiology of sepsis in older adults compared to middle-aged and young adults. Design: Prospective longitudinal study with patients categorized into young (≤ 45 years), middle-aged (46-64 years) and older (≥ 65 years) patient groups. 328 sepsis patients were characterized by a) baseline demographics and predisposition factors, b) septic event, c) hospital outcomes and discharge disposition, d) 12-month mortality and e) Zubrod Performance status, physical function and cognitive function at three, six and 12-month follow-up. Follow-up visits were not completed due to death (in 68) and withdrawal of consent (in 32). Compared to young and middle-aged patients, older patients had: 1) significantly more comorbidities at presentation (example chronic renal disease 6% vs 12 % vs 21%), intra-abdominal infections (14% vs 25% vs 37%), septic shock (12% vs 25% vs 36%) and organ dysfunctions, 2) higher 30 day mortality (6% vs 4% vs 17%) and fewer ICU free days (median 25 vs 23 vs 20), 3) more progression into CCI (22%, vs 34% vs 42%) with higher poor disposition discharge to non-home destinations (19% vs 40% vs 62%), 4) worse 12-month mortality (11% vs 14 % vs 33%) and, 5) poorer Zubrod Performance status and objectively-measured physical and cognitive functions with slight improvement over 12 month follow-up. Conclusion: Compared to younger patients, older sepsis survivors suffer with both a higher persistent disability burden and 12-month mortality.

Short echo time proton spectroscopy of the brain in healthy volunteers using an insert gradient head coil

1995 ◽  
Vol 13 (1) ◽  
pp. 105-109 ◽  
Author(s):  
Peter Gideon ◽  
Else Rubæk Danielsen ◽  
Monika Schneider ◽  
Ole Henriksen
Keyword(s):  
Healthy Volunteers ◽  
Proton Spectroscopy ◽  
Echo Time ◽  
Short Echo Time ◽  
The Brain ◽  
Head Coil

scholarly journals Comparison of two programs for quantification of 1H MR spectra of rat brain using a vascular dementia model

2015 ◽  
Vol 8 (1) ◽  
pp. 11-16
Author(s):  
Mária Jozefovičová ◽  
Ivica Just ◽  
Tibor Liptaj ◽  
Svatava Kašparová
Keyword(s):  
Magnetic Resonance ◽  
Vascular Dementia ◽  
Pathological Conditions ◽  
Brain Metabolite ◽  
Metabolite Concentrations ◽  
Echo Time ◽  
Short Echo Time ◽  
The Brain

Abstract The quantification of in vivo 1H magnetic resonance (MR) spectra measured from the rat brains provides important information about the brain metabolite concentrations and can help to understand the role of the metabolites under normal and pathological conditions. The purpose of this study was to compare the most frequently used algorithms for quantification of 1H spectra: LCModel (Linear Combination of Model spectra) and QUEST (QUantitation based on QUantum ESTimation) from jMRUI software (Java based Magnetic Resonance User Interface). The comparison was done on a rat model of vascular dementia (VD). The MR spectra were measured on 4.7T spectrometer with ultra-short echo time by sequence SPECIAL. For these types of spectra the contribution from the macromolecules and lipids is large. Our analysis revealed that all values determined by QUEST, except for one value, were lower in comparison to values obtained by LCModel. The minimal differences were found in N-acetylaspartate/(phospho) creatine (−0.3 %) and maximal in inositol in both control and VD rats. This underestimation of a metabolite concentration in QUEST may be caused by an overestimation of baseline. Although our study found the different values of metabolite concentrations by these two methods, the quantified metabolite changes in pathological brain were comparable in both analyses.

Short echo time proton spectroscopy of the brain in HIV infection/AIDS

1995 ◽  
Vol 13 (6) ◽  
pp. 871-875 ◽  
Author(s):  
M. Paley ◽  
I.D. Wilkinson ◽  
M.A. Hall-Craggs ◽  
W.K. Chong ◽  
R.J.S. Chinn ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Proton Spectroscopy ◽  
Echo Time ◽  
Short Echo Time ◽  
The Brain

scholarly journals Mesocephaly to Brachycephaly Shift as Seen in Punjabi Children

2012 ◽  
Vol 1 (2) ◽  
pp. 1
Author(s):  
H. Kaur ◽  
S. Singh ◽  
V. V. G. Patnaik ◽  
S. Kaushal ◽  
G. Agnihotri
Keyword(s):  
Intracranial Volume ◽  
Brain Growth ◽  
Cephalic Index ◽  
Anthropometric Parameters ◽  
Indian Children ◽  
Prospective Longitudinal Study ◽  
Ethnic Variations ◽  
Prospective Longitudinal ◽  
The Brain

<p>Anthropometric Parameters are useful tools in evaluating growth and development. Cephalic Index helps in estimation of intracranial volume in vivo &amp; thus the brain growth. This prospective longitudinal study was initiated to compare the ethnic variations in cephalic index in specific defined ethnic groups of Punjab Jat Sikh and Bania infants.</p><p>It was observed that Jatsikh infants had a brachycephalic type of skull throughout the study whereas Bania infants displayed mesocephalic type of skull till 7<sup>th</sup> month of their lives and later on even they became brachycephalic in their skull shapes. It is apparent that the trend in replacing mesocephaly by brachycephaly in northern Indian children, wherein possibly Jatsikh children are ahead of Bania children in this process.</p>

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