Mesocephaly to Brachycephaly Shift as Seen in Punjabi Children

Anthropometric Parameters are useful tools in evaluating growth and development. Cephalic Index helps in estimation of intracranial volume in vivo & thus the brain growth. This prospective longitudinal study was initiated to compare the ethnic variations in cephalic index in specific defined ethnic groups of Punjab Jat Sikh and Bania infants.It was observed that Jatsikh infants had a brachycephalic type of skull throughout the study whereas Bania infants displayed mesocephalic type of skull till 7th month of their lives and later on even they became brachycephalic in their skull shapes. It is apparent that the trend in replacing mesocephaly by brachycephaly in northern Indian children, wherein possibly Jatsikh children are ahead of Bania children in this process.

Download Full-text

Comparison of anthropometric indices for predicting the risk of metabolic syndrome and its components in Chinese adults: a prospective, longitudinal study

BMJ Open ◽

10.1136/bmjopen-2017-016062 ◽

2017 ◽

Vol 7 (9) ◽

pp. e016062 ◽

Cited By ~ 37

Author(s):

Haoyu Wang ◽

Aihua Liu ◽

Tong Zhao ◽

Xun Gong ◽

Tianxiao Pang ◽

...

Keyword(s):

Metabolic Syndrome ◽

Roc Curve ◽

Volume Index ◽

Anthropometric Parameters ◽

Anthropometric Indices ◽

Prospective Longitudinal Study ◽

Adiposity Index ◽

Significant Difference ◽

Prospective Longitudinal

ObjectivesOur study aimed to distinguish the ability of anthropometric indices to assess the risk of metabolic syndrome (MetS).DesignProspective cohort study.SettingShenyang, China.ParticipantsA total of 379 residents aged between 40 and 65 were enrolled. 253 of them were free of MetS and had been followed up for 4.5 years.MethodsAt baseline, all the participants underwent a thorough medical examination. A variety of anthropometric parameters were measured and calculated, including waist circumference (WC), body mass index (BMI), a body shape index (ABSI), abdominal volume index (AVI), body adiposity index, body roundness index, conicity index, waist-to-hip ratio and visceral adiposity index (VAI). After 4.5 year follow-up, we re-examined whether participants were suffering from MetS. A receiver operating characteristic (ROC) curve was applied to examine the potential of the above indices to identify the status and risk of MetS.OutcomesOccurrence of MetS.ResultsAt baseline, 33.2% participants suffered from MetS. All of the anthropometric indices showed clinical significance, and VAI was superior to the other indices as it was found to have the largest area under the ROC curve. After a 4.5 year follow-up, 37.8% of men and 23.9% of women developed MetS. ROC curve analysis suggested that baseline BMI was the strongest predictor of MetS for men (0.77 (0.68–0.85)), and AVI was the strongest for women (0.72 (0.64–0.79)). However, no significant difference was observed between WC and both indices. In contrast, the baseline ABSI did not predict MetS in both genders.ConclusionsThe present study indicated that these different indices derived from anthropometric parameters have different discriminatory abilities for MetS. Although WC did not have the largest area under the ROC curve for diagnosing and predicting MetS, it may remain a better index of MetS status and risk because of its simplicity and wide use.

Download Full-text

BIOM-09. MYO-INOSITOL LEVELS ON MR SPECTROSCOPY CAN PREDICT FAILURE OF ANTI-ANGIOGENIC TREATMENT IN RECURRENT GLIOBLASTOMA

Neuro-Oncology ◽

10.1093/neuonc/noab196.040 ◽

2021 ◽

Vol 23 (Supplement_6) ◽

pp. vi11-vi12

Author(s):

Mohamed El-Abtah ◽

Michael Wenke ◽

Pratik Talati ◽

Melanie Fu ◽

Daniel Kim ◽

...

Keyword(s):

Spectroscopic Data ◽

Recurrent Glioblastoma ◽

Term Survival ◽

Prospective Longitudinal Study ◽

Normal Appearing White Matter ◽

Echo Time ◽

Short Echo Time ◽

Prospective Longitudinal ◽

The Brain ◽

Glial Marker

Abstract BACKGROUND Recurrent glioblastoma (rGBM) patients are often treated with anti-angiogenic agents such as bevacizumab (BEV). Despite therapeutic promise, conventional MR methods fail to determine which patients may not benefit. PURPOSE: The purpose of this study was to utilize magnetic resonance spectroscopic imaging (MRSI) with intermediate and short echo time to generate corrected Myo-inositol normalized by contralateral creatine (mI/c-Cr) in patients with rGBM treated with BEV and investigate whether it can predict survivorship prior to BEV initiation (baseline) and at 1-day, 4-weeks, and 8-weeks thereafter. METHODS We conducted a prospective, longitudinal study and evaluated spectroscopic data of myo-inositol (mI), a glial marker and osmoregulator within the brain, normalized to contralateral-creatine (mI/c-Cr) in the intratumoral, contralateral normal appearing white matter, and peritumoral volumes of rGBM patients. Area under the ROC curve (AUC) was calculated for all volumes at baseline, 1-day, 4-weeks, and 8-weeks after treatment to determine mI/c-Cr’s ability to predict survivorship. RESULTS 21 participants (62 ± 12 years, 15 men) were evaluated. Lower mI/c-Cr in the tumor prior to and during BEV treatment predicted poor survivorship, with ROC analyses illustrating an AUC of 0.75 at baseline, 0.87 at 1-day, and 1 at 8 weeks. Lower levels of mI/c-Cr were also observed in the contralateral and the peritumoral volumes for shorter-term survivors. In the contralateral volume, lower mI/Cr was predictive of shorter-term survival at baseline and all other timepoints. Within the peritumoral volume, lower mI/c-Cr was predictive of shorter-term survival at baseline (AUC=0.80), 1-day (AUC=0.93), and 4-weeks (AUC=0.68). CONCLUSIONS Lower levels of mI/c-Cr within intratumoral, contralateral, and peritumoral volumes were predictive of poor survivorship and anti-angiogenic treatment failure as early as one month before BEV treatment. Acquiring MRSI alongside conventional MR imaging modalities can convey critical information regarding tumor microenvironment that informs management of patients with rGBM.

Download Full-text

Brain growth retardation due to the expression of human insulin like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain

Developmental Brain Research ◽

10.1016/0165-3806(94)90164-3 ◽

1994 ◽

Vol 82 (1-2) ◽

pp. 213-222 ◽

Cited By ~ 62

Author(s):

A. Joseph D'Ercole ◽

Zonghan Dai ◽

Yuhze Xing ◽

Charlotte Boney ◽

Mary Beth Wilkie ◽

...

Keyword(s):

Growth Factor ◽

Transgenic Mice ◽

Human Insulin ◽

Growth Retardation ◽

In Vivo Model ◽

Insulin Like Growth Factor ◽

Brain Growth ◽

Factor Binding ◽

The Brain

Download Full-text

Effect of HIV-1 Infection and Sex on the Cellular Pharmacology of the Antiretroviral Drugs Zidovudine and Lamivudine

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.06337-11 ◽

2012 ◽

Vol 56 (6) ◽

pp. 3011-3019 ◽

Cited By ~ 10

Author(s):

Joseph E. Rower ◽

Amie Meditz ◽

Edward M. Gardner ◽

Kenneth Lichtenstein ◽

Julie Predhomme ◽

...

Keyword(s):

African American ◽

African Americans ◽

Antiretroviral Drugs ◽

Lean Body Weight ◽

Prospective Longitudinal Study ◽

Cellular Pharmacology ◽

Prospective Longitudinal ◽

Hiv Seropositive ◽

Hiv 1

ABSTRACTThe cellular pharmacology of zidovudine (ZDV) and lamivudine (3TC)in vivois not completely understood. This prospective longitudinal study investigated the relationship between HIV-1 serostatus, sex, race, and time on therapy with intracellular and plasma ZDV and 3TC concentrations. Of 20 HIV-seronegative and 23 HIV-seropositive volunteers enrolled, 16 (8 women) and 21 (5 women) completed all 12 study days, respectively. Volunteers began ZDV-3TC therapy (plus a third active drug in HIV-seropositive volunteers), and steady-state concentrations (Css) were determined after days 1, 3, 7, and 12. A repeated-measures mixed model was utilized. HIV-seronegative status was associated with 22% (95% confidence interval [CI], 0%, 50%) and 37% (15%, 67%) higherCssestimates compared to those of HIV-seropositive individuals for intracellular ZDV-TP and 3TC-TP levels, respectively. African-Americans had 36% (8%, 72%) higher ZDV-TP estimates than non-African-Americans. Sex was not associated with ZDV-TP or 3TC-TP (P> 0.19). Women had 36% (4%, 78%) higher plasma ZDV, but the effect was lessened when normalized by lean body weight (5% [−19%, 38%];P= 0.68). Plasma 3TC was 19% (0%, 41%) higher in HIV-seropositive volunteers and 22% (0%, 48%) higher in African American volunteers, but these effects were not significant when corrected for creatinine clearance (7% [−9%, 20%] and −5% [−26%, 12%] for HIV serostatus and race, respectively;P> 0.35). These results suggest that HIV-seropositive status decreases and African American race elevates the cellular triphosphates of ZDV and 3TC. This information extends knowledge of ZDV and 3TC cellular pharmacologyin vivoand provides new leads for future cellular pharmacology studies aimed at optimizing HIV prevention/treatment with these agents.

Download Full-text

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

Development ◽

10.1242/dev.128.24.5201 ◽

2001 ◽

Vol 128 (24) ◽

pp. 5201-5212 ◽

Cited By ~ 1

Author(s):

Nadia Dahmane ◽

Pilar Sánchez ◽

Yorick Gitton ◽

Verónica Palma ◽

Tao Sun ◽

...

Keyword(s):

Brain Tumors ◽

Sonic Hedgehog ◽

Brain Structures ◽

Brain Growth ◽

Shh Signaling ◽

In Vivo Assays ◽

Plastic Process ◽

The Brain

The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex and tectum, whereas the Gli genes, which are targets and mediators of SHH signaling, are expressed in proliferative zones. In vitro and in vivo assays show that SHH is a mitogen for neocortical and tectal precursors and that it modulates cell proliferation in the dorsal brain. Together with its role in the cerebellum, our findings indicate that SHH signaling unexpectedly controls the development of the three major dorsal brain structures. We also show that a variety of primary human brain tumors and tumor lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor, inhibits the proliferation of tumor cells. Using the in vivo tadpole assay system, we further show that misexpression of GLI1 induces CNS hyperproliferation that depends on the activation of endogenous Gli1 function. SHH-GLI signaling thus modulates normal dorsal brain growth by controlling precursor proliferation, an evolutionarily important and plastic process that is deregulated in brain tumors.

Download Full-text

Effect of pH and inhibitors on beta-amyloid fibril assembly

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100166221 ◽

1996 ◽

Vol 54 ◽

pp. 752-753

Author(s):

Beverly E. Maleeff ◽

Timothy K. Hart ◽

Stephen J. Wood ◽

Ronald Wetzel

Keyword(s):

Amyloid Fibril ◽

Peptide Fragment ◽

Hydrophobic Peptides ◽

Amyloid Fibril Formation ◽

Effects Of Ph ◽

Severity Of The Disease ◽

Kinetics Of ◽

The Brain

Alzheimer's disease is characterized post-mortem in part by abnormal extracellular neuritic plaques found in brain tissue. There appears to be a correlation between the severity of Alzheimer's dementia in vivo and the number of plaques found in particular areas of the brain. These plaques are known to be the deposition sites of fibrils of the protein β-amyloid. It is thought that if the assembly of these plaques could be inhibited, the severity of the disease would be decreased. The peptide fragment Aβ, a precursor of the p-amyloid protein, has a 40 amino acid sequence, and has been shown to be toxic to neuronal cells in culture after an aging process of several days. This toxicity corresponds to the kinetics of in vitro amyloid fibril formation. In this study, we report the biochemical and ultrastructural effects of pH and the inhibitory agent hexadecyl-N-methylpiperidinium (HMP) bromide, one of a class of ionic micellar detergents known to be capable of solubilizing hydrophobic peptides, on the in vitro assembly of the peptide fragment Aβ.

Download Full-text

Microvascular features that suggest effectors of blood-flow regulation in the brain: Evidence by SEM of corrosion casts of intracerebral vessels

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158923 ◽

1990 ◽

Vol 48 (3) ◽

pp. 274-275

Author(s):

Enrico D.F. Motti ◽

Hans-Georg Imhof ◽

Gazi M. Yasargil

Keyword(s):

Blood Flow ◽

Perfusion Pressure ◽

Corrosion Casts ◽

Cerebral Microcirculation ◽

Pial Arteries ◽

Random Occurrence ◽

Brain Arteries ◽

Homogeneous Network ◽

The Brain

Physiologists have devoted most attention in the cerebrovascular tree to the arterial side of the circulation which has been subdivided in three levels: 1) major brain arteries which keep microcirculation constant despite changes in perfusion pressure; 2) pial arteries supposed to be effectors regulating microcirculation; 3) intracerebral arteries supposed to be deprived of active cerebral blood flow regulating devices.The morphological search for microvascular effectors in the cerebrovascular bed has been elusive. The opaque substance of the brain confines in vivo investigation to the superficial pial arteries. Most morphologists had to limit their observation to the random occurrence of a favorable site in the practically two-dimensional thickness of diaphanized histological sections. It is then not surprising most investigators of the cerebral microcirculation refer to an homogeneous network of microvessels interposed between arterioles and venules.We have taken advantage of the excellent depth of focus afforded by the scanning electron microscope (SEM) to investigate corrosion casts obtained injecting a range of experimental animals with a modified Batson's acrylic mixture.

Download Full-text