scholarly journals TMOD-02BLOCKING CXCR4 INCREASES SURVIVAL IN A MOUSE MODEL OF NEURAL STEM CELLS-DERIVED GLIOBLASTOMA BY BLOCKING AN AUTOCRINE POSITIVE FEEDBACK LOOP REGULATING APOPTOSIS AND CELL CYCLE PROGRESSION VIA Rb1 AND cdk4/cdk6/CyclinD1

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v226.2-v226
Author(s):  
Alexandra Calinescu ◽  
Erica Carballo ◽  
Dustin Tran ◽  
Daniel Zamler ◽  
Robert Doherty ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Mouse Model ◽  
Neural Stem Cells ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Positive Feedback Loop

scholarly journals A Positive Feedback Loop between ATOH7 and a Notch Effector Regulates Cell-Cycle Progression and Neurogenesis in the Retina

Cell Reports ◽  
2013 ◽  
Vol 3 (3) ◽  
pp. 796-807 ◽  
Author(s):  
Florence Chiodini ◽  
Lidia Matter-Sadzinski ◽  
Tania Rodrigues ◽  
Dorota Skowronska-Krawczyk ◽  
Laurent Brodier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Positive Feedback Loop

The cdc25B phosphatase is essential for the G2/M phase transition in human cells

1998 ◽  
Vol 111 (16) ◽  
pp. 2445-2453 ◽  
Author(s):  
C. Lammer ◽  
S. Wagerer ◽  
R. Saffrich ◽  
D. Mertens ◽  
W. Ansorge ◽  
...  
Keyword(s):  
Phase Transition ◽  
Cell Cycle ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Cell Cycle Progression ◽  
S Phase ◽  
Human Cells ◽  
Cycle Progression ◽  
Positive Feedback Loop ◽  
M Phase

Cdc25 phosphatases play key roles in cell cycle progression by activating cyclin-dependent kinases. In human cells, cdc25 proteins are encoded by a multigene family, consisting of cdc25A, cdc25B and cdc25C. While cdc25A plays a crucial role at the G1/S phase transition, cdc25C is involved in the dephosphorylation and activation of the mitotic kinase, cdc2/cyclinB. In addition, cdc25C itself is regulated by cdc2/cyclinB which then creates a positive feedback loop that controls entry into mitosis. In this study we show that the activity of cdc25B appears during late S phase and peaks during G2 phase. Both in vitro and in vivo cdc25B is activated through phosphorylation during S-phase. Using a cell duplication, microinjection assay we show that ablation of cdc25B function by specific antibodies blocks cell cycle progression in Hs68 cells by inhibition of entry into mitosis. Cdc25B function neither plays a role in later stages of mitosis nor for the inititation of DNA replication. These results indicate that cdc25B is a mitotic regulator that might act as a ‘starter phosphatase’ to initiate the positive feedback loop at the entry into M phase.

scholarly journals Amyloid Precursor Protein Binding Protein-1 Modulates Cell Cycle Progression in Fetal Neural Stem Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e14203 ◽  
Author(s):  
Yuyoung Joo ◽  
Sungji Ha ◽  
Bo-Hyun Hong ◽  
Jeong a Kim ◽  
Keun-A Chang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Precursor Protein ◽  
Protein Binding ◽  
Cell Cycle Progression ◽  
Binding Protein ◽  
Precursor Protein ◽  
Cycle Progression

scholarly journals Nuclear Receptor TLX Regulates Cell Cycle Progression in Neural Stem Cells of the Developing Brain

2008 ◽  
Vol 22 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Wenwu Li ◽  
Guoqiang Sun ◽  
Su Yang ◽  
Qiuhao Qu ◽  
Kinichi Nakashima ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Nuclear Receptor ◽  
Neural Development ◽  
Cell Cycle Progression ◽  
Kinase Inhibitor ◽  
Developing Brain ◽  
Cell Cycle Exit ◽  
Cycle Progression

Abstract TLX is an orphan nuclear receptor that is expressed exclusively in vertebrate forebrains. Although TLX is known to be expressed in embryonic brains, the mechanism by which it influences neural development remains largely unknown. We show here that TLX is expressed specifically in periventricular neural stem cells in embryonic brains. Significant thinning of neocortex was observed in embryonic d 14.5 TLX-null brains with reduced nestin labeling and decreased cell proliferation in the germinal zone. Cell cycle analysis revealed both prolonged cell cycles and increased cell cycle exit in TLX-null embryonic brains. Increased expression of a cyclin-dependent kinase inhibitor p21 and decreased expression of cyclin D1 provide a molecular basis for the deficiency of cell cycle progression in embryonic brains of TLX-null mice. Furthermore, transient knockdown of TLX by in utero electroporation led to precocious cell cycle exit and differentiation of neural stem cells followed by outward migration. Together these results indicate that TLX plays an important role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain.

Amyloid precursor protein binding protein-1 modulates cell cycle progression of neural stem cells

2010 ◽  
Vol 68 ◽  
pp. e450
Author(s):  
Hee Jin Kim ◽  
Yuyoung Joo ◽  
Bo-Hyun Hong ◽  
Sungji Ha ◽  
Jeong-A Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Precursor Protein ◽  
Protein Binding ◽  
Cell Cycle Progression ◽  
Binding Protein ◽  
Precursor Protein ◽  
Cycle Progression

Effect of Optogenetic Stimulus on the Proliferation and Cell Cycle Progression of Neural Stem Cells

2014 ◽  
Vol 247 (6) ◽  
pp. 493-500 ◽  
Author(s):  
Shao Jun Wang ◽  
Chuan Huang Weng ◽  
Hai Wei Xu ◽  
Cong Jian Zhao ◽  
Zheng Qin Yin
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Cell Cycle Progression ◽  
Cycle Progression

scholarly journals Expression of Cell Cycle–Related Genes With Cytokine-Induced Cell Cycle Progression of Primitive Hematopoietic Stem Cells

2010 ◽  
Vol 19 (4) ◽  
pp. 453-460 ◽  
Author(s):  
Peter J. Quesenberry ◽  
Gerri J. Dooner ◽  
Michael Del Tatto ◽  
Gerald A. Colvin ◽  
Kevin Johnson ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Hematopoietic Stem
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