scholarly journals Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study

Neurosurgery ◽  
2018 ◽  
Vol 84 (3) ◽  
pp. 717-725 ◽  
Author(s):  
Dale Ding ◽  
Gautam U Mehta ◽  
Mohana Rao Patibandla ◽  
Cheng-Chia Lee ◽  
Roman Liscak ◽  
...  
Keyword(s):  
Cohort Study ◽  
Stereotactic Radiosurgery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
International Multicenter

Tumor Control Following Stereotactic Radiosurgery in Patients with Vestibular Schwannomas – A Retrospective Cohort Study

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Peter L. Santa Maria ◽  
Yangyang Shi ◽  
Ksenia A. Aaron ◽  
Richard K. Gurgel ◽  
C. Eduardo Corrales ◽  
...  
Keyword(s):  
Cohort Study ◽  
Stereotactic Radiosurgery ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Vestibular Schwannomas ◽  
Tumor Control

scholarly journals Hypothermia and Meconium Aspiration Syndrome: International Multicenter Retrospective Cohort Study

2016 ◽  
Vol 194 (3) ◽  
pp. 381-384 ◽  
Author(s):  
Daniele De Luca ◽  
David G. Tingay ◽  
Anton van Kaam ◽  
Werther Brunow de Carvalho ◽  
Eva Valverde ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration ◽  
International Multicenter

scholarly journals Longitudinal Radiographic Outcomes of Vestibular Schwannoma in Single and Fractionated Stereotactic Radiosurgery: A Retrospective Cohort Study

2019 ◽  
Vol 81 (03) ◽  
pp. 308-316
Author(s):  
Mohamed H. Khattab ◽  
Neil B. Newman ◽  
David M. Wharton ◽  
Alexander D. Sherry ◽  
Guozhen Luo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Treatment Failure ◽  
Stereotactic Radiosurgery ◽  
Vestibular Schwannoma ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Treatment Success ◽  
Three Dimensional ◽  
Target Volume ◽  
Surveillance Imaging

AbstractManagement of vestibular schwannoma (VS) includes stereotactic radiosurgery (SRS) in single or fractionated treatments. There is a paucity of literature on the three-dimensional (3D) volumetric kinetics and radiological changes following SRS and no consensus on appropriate post-SRS surveillance imaging timeline. This is a retrospective cohort study with institutional review board approval. A total of 55 patients met study criteria. We collected volumetric kinetic data in VS treated with SRS over time using a target volume contouring software. We also tracked radiographic phenomena such as pseudoprogression and necrosis. A secondary objective was to describe our overall treatment success rate and any failures. For all treatments groups, pseudoprogression most typically occurred within 12 months post-SRS, after which tumor volumes on average normalized and then decreased from pretreatment size at the last follow-up. Only two patients required salvage therapy post-SRS and were considered SRS treatment failures. Both patients were in the five-fraction cohort but with a lower biologically equivalent dose. Our study is first to collect 3D volumetric kinetics of VS following single and fractionated SRS in contrast to extrapolations from single and two-dimensional measurements. Our longitudinal data also show initial increases in volume in the first 12 months post-SRS followed by later declines, setting up interesting questions regarding the utility of early posttreatment surveillance imaging in the asymptomatic patient. Finally, we show low rates of treatment failure (3.6%) and show in our cohort that SRS dose de-escalation posed a risk of treatment failure.

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