Two-Year Clinical, Cerebral Hemodynamic, and Cognitive Outcomes of Adult Patients Undergoing Medication Alone for Symptomatically Ischemic Moyamoya Disease Without Cerebral Misery Perfusion: A Prospective Cohort Study

Neurosurgery ◽  
2018 ◽  
Vol 84 (6) ◽  
pp. 1233-1241 ◽  
Author(s):  
Kenya Miyoshi ◽  
Kohei Chida ◽  
Masakazu Kobayashi ◽  
Yoshitaka Kubo ◽  
Kenji Yoshida ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Moyamoya Disease ◽  
Prospective Cohort ◽  
Cognitive Outcomes ◽  
Adult Patients ◽  
Cerebral Hemodynamic ◽  
Misery Perfusion

Asymptomatic Cerebral Microbleeds in Adult Patients with Moyamoya Disease: A Prospective Cohort Study with 2 Years of Follow-Up

2013 ◽  
Vol 35 (5) ◽  
pp. 469-475 ◽  
Author(s):  
Wen Sun ◽  
Cuiping Yuan ◽  
Wenhua Liu ◽  
Yongkun Li ◽  
Zhixin Huang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Moyamoya Disease ◽  
Prospective Cohort ◽  
Cerebral Microbleeds ◽  
Adult Patients

Abstehende Ohren: Otoplastik wirkt sich positiv auf psychosoziale Probleme aus

2019 ◽  
Vol 98 (09) ◽  
pp. 603-604
Author(s):  
Jörg Lindemann
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Adult Patients ◽  
Operative Korrektur ◽  
Psychosocial Effects ◽  
Psychosoziale Probleme

Sirin S et al. Psychosocial effects of otoplasty in adult patients: a prospective cohort study. Eur Arch Otorhinolaryngol 2019: 276: 1533–1539 Die operative Korrektur abstehender Ohren ist der häufigste ästhetische Eingriff im Alter unter 18 Jahren. Der psychosoziale Nutzen: Weniger Ängste, ein höheres Selbstwertgefühl und eine bessere Körperbildwahrnehmung. Ob Erwachsene gleichermaßen profitieren, ist bislang nur unzureichend untersucht. Eine Studie der türkischen Universität Kocaeli ist dieser Frage nachgegangen.

scholarly journals Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038552
Author(s):  
Rishi Mandavia ◽  
Gerjon Hannink ◽  
Muhammad Nayeem Ahmed ◽  
Yaami Premakumar ◽  
Timothy Shun Man Chu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Cohort Study ◽  
Sensorineural Hearing Loss ◽  
Prospective Cohort Study ◽  
Health Research ◽  
Prospective Cohort ◽  
Prognostic Model ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Adult Patients

IntroductionThe mainstay of treatment for idiopathic sudden sensorineural hearing loss (SSNHL) includes oral steroids, intratympanic steroid injections or a combination of both. The National Institute for Health and Care Excellence, in their recent hearing loss guidelines, highlighted the paucity of evidence assessing the comparative effectiveness of these treatments; and the National Institute for Health Research (NIHR) Health Technology Assessment Programme has since released a commissioned call for a trial to identify the most effective route of administration of steroids as a first-line treatment for idiopathic SSNHL. For such trials to be run effectively, reliable information is needed on patients with SSNHL: where they present, numbers, demographics, treatment pathways, as well as outcomes. This study will collect these data in a nationwide cohort study of patients presenting with SSNHL across 97 National Health Service (NHS) trusts. The study will be delivered through ear, nose and throat (ENT) trainee networks, the NIHR Clinical Research Network (CRN) Audiology Champions and the NIHR CRN. Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. The study objectives are to: (1) map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL, (2) develop a prognostic model to predict recovery for patients with idiopathic SSNHL and (3) establish the impact of idiopathic SSNHL on patients’ quality of life (QoL).Methods and analysisStudy design: national multicentre prospective cohort study across 97 NHS trusts.Inclusion criteria: adult patients presenting to NHS ENT and hearing services with SSNHL.Outcomes: change in auditory function; change in QoL score.Analysis: multivariable prognostic model, using prespecified candidate predictors. Mean change in QoL scores will be calculated from initial presentation to follow-up.Ethics and disseminationHealth Research Authority and NHS Research Ethics Committee approved the study. Publication will be on behalf of study sites and collaborators.Trial registration numberClinicalTrials.gov Registry (NCT04108598).

scholarly journals The Association Between Residual Neuromuscular Blockade (RNMB) and Critical Respiratory Events: A Prospective Cohort Study

2020 ◽  
Author(s):  
Faraj Alenezi ◽  
Khalid Alnababtah ◽  
Mohammed Alqahtani ◽  
Mohammed Al Harbi
Keyword(s):  
Cohort Study ◽  
General Anaesthesia ◽  
Neuromuscular Blockade ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Neuromuscular Monitoring ◽  
Adult Patients ◽  
Residual Neuromuscular Blockade ◽  
Respiratory Events ◽  
Pacu Stay

Abstract Background: Inadequate neuromuscular recovery might impair pulmonary function among adult patients who undergo general anaesthesia and might thus contribute to critical respiratory events in the post-anaesthesia care unit (PACU). The aim of this study to investigate whether critical respiratory events (CREs) that described in a modified Murphy’s criteria are significantly associated with residual neuromuscular blockade (RNMB).Method: A prospective cohort study from January to March 2017 from a tertiary hospital from Saudi Arabia for thirty adult patients over 18 years old scheduled for elective surgery under general anaesthesia with neuromuscular blocking drugs (NMBDs) were enrolled in the study. The Mann-Whitney U tests, Chi-Square tests and Independent-Samples T tests were used. The Train-of-four (TOF) ratios were measured upon arrival in the PACU by using Acceleromyography with TOF-Scan. Subjects’ demographics, perioperative data, and the occurrence of postoperative CREs in the PACU were recorded.Results: 26 (86.7%) patients out of thirty in the study has received Rocuronium as NMBDs while Neostigmine as a reversal drug with only 23 (76.7%). The incidence of RNMB (TOF ratio < 0.9) was in 16 patients (53.3%). The incidence of RNMB was significantly higher in female patients (p= 0.033), in patients who had not undergone quantitative neuromuscular monitoring before extubation (p= 0.046) and in patients with shorter duration of surgery (p= 0.001). Postoperative CREs occurred in twenty patients (66.7%), and there were significantly more of these CREs among patients with RNMB (P= 0.001). In addition, a statistically significant difference was observed in the occurrence of CREs according to body mass index (P= 0.047).Conclusion: This research showed that RNMB is a significant contributing factor to the development of critical respiratory events during PACU stay. Therefore, optimal antagonism of neuromuscular blockade and routine quantitative neuromuscular monitoring are recommended to reduce the incidence of RNMB.

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