scholarly journals Ocular syphilis: Case Series (2000–2015) from Two Tertiary Care Centers in Montreal

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S105-S105
Author(s):  
Julie Vadboncoeur ◽  
Yasmine Rabia ◽  
Marie-Josée Aubin ◽  
Annie-Claude Labbé ◽  
Laurence Jaworsky ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Tertiary Care ◽  
Case Series ◽  
Penicillin G ◽  
Ocular Involvement ◽  
Reference Laboratory ◽  
Ocular Syphilis ◽  
Nerve Involvement ◽  
Interstitial Keratitis ◽  
Optic Nerve Involvement

Abstract Background In the past 15 years, a recrudescence of syphilis was observed in Canada, along with a surge in ocular syphilis cases. Without treatment, ocular syphilis can have serious consequences potentially leading to blindness. Our goal was to describe the demographics, clinical presentations, proportion of co-infection with HIV, treatments and visual outcomes of ocular syphilis cases. Methods Patients with a confirmed positive syphilis serology between 2000 and 2015 were identified through the reference laboratory database. A retrospective chart review was performed for those who visited the ophthalmology clinic of Hôpital Maisonneuve-Rosemont or Hôpital Notre-Dame to identify ocular syphilis cases. Results Among the 119 patients (174 eyes) identified (2.5% of the population screened), 80% were male; of which 63% were MSM. Mean presenting logMAR visual acuity was 0.70 (20/100 Snellen) and unilateral ocular involvement occurred in 54%. Ocular manifestations included interstitial keratitis (24 eyes), anterior uveitis (37 eyes), intermediate uveitis (17 eyes), posterior uveitis (31 eyes), panuveitis (27 eyes), isolated optic nerve involvement (25 eyes), and others (12 eyes) including VI nerve palsy, scleritis, and episcleritis. Cerebrospinal fluid (CSF) examination was done in 65 (55%) patients. Of those, VDRL was positive in 14 (22%) patients; white blood cells and proteins were elevated in, respectively, 28 (43%) and 39 (60%) of patients. HIV status was unknown in 39 (33%) patients; among those whose serology were performed (or previous status was known), 38 (48%) were HIV infected. Intravenous aqueous penicillin G was administered in 69 (58%), intramuscular benzathine penicillin in 25 (21%) and other antibiotics, mainly due to allergy, in three (3%) patients. Treatment allowed a visual improvement of –0.22 logMAR (gain of five lines on Snellen chart) after a mean follow-up period of 19 months. Conclusion Syphilis can manifest with a widely diversified array of ocular presentations, especially uveitis and optic nerve involvement. Therefore it is primordial to keep this diagnosis in mind when facing high-risk patients with ocular symptoms. It is of utmost importance that clinicians improve rates of lumbar puncture, HIV screening and intraveinous penicillin treatment when managing ocular syphilis. Disclosures All authors: No reported disclosures.

scholarly journals A clinical study of optic nerve involvement in patients with tuberculosis attending a tertiary health care center in North East

2021 ◽  
Vol 9 (2) ◽  
pp. 498
Author(s):  
Mitali Borooah ◽  
Amar Jyoti Malakar
Keyword(s):  
Optic Nerve ◽  
Tertiary Care ◽  
Common Finding ◽  
Care Hospital ◽  
Tuberculosis Patients ◽  
Ocular Manifestations ◽  
Nerve Involvement ◽  
Pulmonary Manifestations ◽  
Ocular Tb ◽  
Optic Nerve Involvement

 Background: To screen for ocular finding of optic nerve involvement in patients with tuberculosis and documents these findings.Methods: The hospital based observational study was carried out in a tertiary care hospital in Assam  for  the duration of July 2018 to June 2019 in 384 diagnosed cases of tuberculosis patients who fulfil  the inclusion criteria during the study period.Results: 11 cases with optic nerve involvement was found out of 384 tuberculosis patients. Most common presenting complain was blurring of vision. Unilateral involvement was maximum. Most common finding was disc oedema.  Ocular TB cases was higher in extrapulmonary TB patients.Conclusions: Diagnosis of ocular Tb is mainly presumptive, based on history, clinical examination, adjunctive diagnostic tests and response to anti tuberculous therapy. Amongst 384 TB cases ocular manifestations were found in 11 cases and therefore, we can conclude that ocular manifestations hold significance in extra pulmonary manifestations of TB. So, TB patients need to have routine ocular examination for the early diagnosis and timely management.

Isolated optic nerve involvement in acute lymphoblastic leukaemia: a red flag for early relapse

2021 ◽  
Vol 14 (6) ◽  
pp. e243689
Author(s):  
Shorya Vardhan Azad ◽  
Mousumi Banerjee ◽  
Kumar Parmanand ◽  
Pradeep Venkatesh
Keyword(s):  
Optic Nerve ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Maintenance Phase ◽  
Central Nervous System Relapse ◽  
Ocular Involvement ◽  
Nerve Involvement ◽  
Red Flag ◽  
Optic Nerve Involvement ◽  
Fluid Cytology

Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer, with 70%–80% of cases curable with modern chemotherapy. However, 20% of the cases suffer from disease relapse with bone marrow being the most common site. Isolated ocular involvement as the first sign of relapse is extremely rare, occurring in less than 2.2% of cases. The presentation of optic nerve involvement in leukaemia represents a visual emergency and a sign of isolated central nervous system relapse even in the absence of abnormal cerebrospinal fluid cytology. This case highlights the importance of routine ophthalmic screening in ALL even during maintenance phase and prompt initiation of treatment in cases with isolated optic nerve involvement.

Isolated optic nerve involvement in chronic myeloid leukemia

1992 ◽  
Vol 16 (4) ◽  
pp. 411-413 ◽  
Author(s):  
Ciro Costagliola ◽  
Mario Rinaldi ◽  
Luigi Cotticelli ◽  
Sandro Sbordone ◽  
Giacomo Nastri
Keyword(s):  
Optic Nerve ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Nerve Involvement ◽  
Optic Nerve Involvement

scholarly journals Swept Source Optical Coherence Tomography Documenting Optic Nerve Involvement in an Aggressive T-Cell Lymphoma

2020 ◽  
pp. 1-4
Author(s):  
Layla Maris Areas ◽  
Fabio Lavinsky ◽  
Daniel Lavinsky ◽  
Rodrigo Leivas Lindenmeyer ◽  
Helena Messinger Pakter ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
T Cell ◽  
Optic Nerve ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Optical Coherence ◽  
Swept Source ◽  
Nerve Involvement ◽  
Optic Nerve Involvement

Optic Nerve Involvement in Farber Lipogranulomatosis

2019 ◽  
Vol 39 (3) ◽  
pp. 391-393
Author(s):  
Abdullah S. Alamri ◽  
Daniah A. Alshowaeir ◽  
Ali A. AlFaiz ◽  
Fatimah H. Al Mousawi ◽  
Adel A. Mahmoud ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Involvement ◽  
Optic Nerve Involvement

scholarly journals A Case of Miller Fischer Syndrome With Optic Nerve Involvement

2010 ◽  
Vol 51 (12) ◽  
pp. 1676 ◽  
Author(s):  
In Ki Park ◽  
Sang Woong Moon ◽  
Ji Sang Han ◽  
Jae Ho Shin
Keyword(s):  
Optic Nerve ◽  
Nerve Involvement ◽  
Optic Nerve Involvement

Optic nerve involvement in posterior paranasal sinus diseases

1989 ◽  
Vol 9 (3) ◽  
pp. 147-155 ◽  
Author(s):  
Masashi Shimo-Oku ◽  
Shigeo Miyazaki ◽  
Kahoru Shiraki ◽  
Taeko Sugimoto ◽  
Haruyuki Sotani
Keyword(s):  
Optic Nerve ◽  
Paranasal Sinus ◽  
Paranasal Sinus Diseases ◽  
Nerve Involvement ◽  
Optic Nerve Involvement

scholarly journals Ocular Involvement in Sarcoidosis

2017 ◽  
Vol 38 (04) ◽  
pp. 514-522 ◽  
Author(s):  
Aniki Rothova ◽  
Fahriye Groen
Keyword(s):  
Optic Nerve ◽  
Systemic Therapy ◽  
Visual Outcome ◽  
Term Treatment ◽  
Ocular Involvement ◽  
Visual Prognosis ◽  
Long Term Treatment ◽  
Chronic Course ◽  
Optic Nerve Involvement

AbstractOcular involvement in sarcoidosis occurs in ∼40% and the eye is the presenting organ in roughly 20%. The course of ocular disease does not necessarily parallel that of systemic disease. Uveitis is the most common presentation and shows mainly a chronic course; anterior uveitis is associated with better visual prognosis than posterior localization. Painful bilateral anterior granulomatous uveitis most commonly occurs in black patients at younger age, while painless posterior bilateral involvement with peripheral multifocal choroiditis is commonly seen in elderly white females. Patients with posterior uveitis develop often ocular complications and central nervous system involvement. Vitritis, segmental periphlebitis, choroidal granulomas, and peripheral multifocal chorioretinitis are often seen clinical features. Optic nerve involvement is uncommon, but if present, results often in poor visual outcome. Lacrimal gland and conjunctival involvement are also common and present clinically as dry eyes or remain asymptomatic with good visual prognosis. Sarcoidosis-associated uveitis is mostly managed by local treatment with steroid drops or periocular and intraocular steroid injections or with novel intraocular corticosteroid implants. Patients with sight-threatening disease or optic nerve involvement need systemic therapy. Systemic therapy is based on a step-up regimen where corticosteroids are used in the initial phase of the disease and if long-term treatment is required, steroid-sparing immunomodulatory drugs are implemented such as methotrexate or biological agents. Despite the mainly chronic course, need for long-term treatment, and frequent ocular surgeries in the majority of patients, the visual outcome of sarcoidosis-associated uveitis is fairly good if therapy has started on time.

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