scholarly journals Butane-induced acute global myocardial ischemia without coronary artery pathology

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Vladimir Grigorov ◽  
Mladen Grigorov ◽  
Evgeni Grigorov ◽  
Hristina Nocheva
Keyword(s):  
Case Report ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Acute Poisoning ◽  
Acute Myocardial Ischemia ◽  
Cardiac Pathology ◽  
The World ◽  
The Brain ◽  
Coronary Artery Pathology ◽  
Propane Butane

ABSTRACT The case report describes a case of acute myocardial ischemia precipitated by propane butane inhalation. The dependency of this substance around the world is still moderate but is increasing due to the easy availability of the substance and the facility with which the effects can be concealed. The toxicity of the substance is significant; affecting the heart, the brain and the liver. The most common outcome is sudden death. In this article, we describe a survivor after an episode of acute poisoning and his interesting cardiac pathology.

Heparin from Intestine and Lung Source Administered in Large Dose to Dogs with Acute Myocardial Ischemia

1978 ◽  
Vol 40 (02) ◽  
pp. 407-417
Author(s):  
Michael J Saliba ◽  
Richard J Pavalec
Keyword(s):  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Adenosine Triphosphate ◽  
Intestinal Mucosa ◽  
Large Dose ◽  
Acute Myocardial Ischemia ◽  
Ischemic Myocardium ◽  
Atp Levels ◽  
Initial Control ◽  
The Difference

SummaryIntestinal mucosa heparin (IMH) and beef lung heparin (BLH) were infused into dogs subjected to myocardial ischemia by intermittent coronary artery occlusions. The IMH was from a mixture of beef, sheep, and pig intestinal mucosa. Initial control occlusion and recovery was followed by a second occlusion with 60,000 units of IMH or BLH added. Electrocardiographic S-T segment elevations (ST) were measured acutely. There were no significant differences in ST in non-ischemic myocardium before occlusions or with occlusions. In ischemic myocardium, IMH significantly lowered control ST 84% in amount (t = 6.1 p <0.00005), and 76% in number (t = 11.6 p <0.00001). BLH lowered control ST a significant, lesser, 36% in amount (t = 3.6 p <0.008), and 35% in number (t = 3.2 p <0.01). The difference between IMH and BLH in ischemic myocardium was a significant 48% in amount (t = 4.0 p <0.0007), and 41% in number (t = 2.0 p <0.06). Myocardial adenosine triphosphate (ATP) levels were assayed after 90 min. ATP levels were 31% higher in both ischemic and non-ischemic myocardium in IMH-treated dogs than in BLH- treated. It was concluded that IMH and BLH are functionally different, and IMH was significantly more effective.

Transcriptome Profile of Hippocampus in Rats Model of Acute Myocardial Ischemia in Response to Electroacupuncture

2020 ◽  
Author(s):  
Xin Wu ◽  
Chenkai Wang ◽  
Kun Wang ◽  
Shuai Cui ◽  
Shengbing Wu ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Transcriptome Profiling ◽  
Arachidonic Acid Metabolism ◽  
Acute Myocardial Ischemia ◽  
Sequencing Analysis ◽  
Beneficial Effects ◽  
Positive Effects ◽  
Gabaergic Synapses ◽  
The Brain ◽  
Gene Expression Levels

Abstract Background: Electroacupuncture (EA) alleviates acute myocardial ischemia (AMI) by regulating some brain areas, including hippocampus. The locus coeruleus (LC) is the main source of norepinephrine (NE) in the brain, including the hippocampus, and regulates cardiovascular function. The aim of the present work was to assess whether LC mediates the positive effects of EA in AMI by altering gene expression levels in the hippocampus. We addressed this in the present study by hippocampus transcriptome profiling in a rat model of AMI following EA treatment. Results: Myocardial injury markers (ischemia-modified albumin, homocysteine and lipoprotein- associated phospholipase A2) in the serum were downregulated in EA (P<0.05) compared to the M group and upregulated in E+L group (P<0.05) compared to E group. RNA sequencing analysis of the hippocampus revealed that the downregulation of 27 genes in M vs S as well as upregulation of 40 genes in M vs S were reversed by EA. These differentially expressed genes, which were validated by quantitative real-time PCR, were enriched in 20 Kyoto Encyclopedia of Genes and Genomes pathways related to glycerolipid, glycerophospholipid, and arachidonic acid metabolism as well asnervous system function (glutamatergic, cholinergic, serotonergic, GABAergic synapses). Conclusions: LC mediates the beneficial effects of EA on AMI-induced injury may be related to the observed transcriptional regulations in the hippocampus. These results provide molecular-level evidence for the therapeutic efficacy of EA in the treatment of AMI.

Vagal reflexes and survival during acute myocardial ischemia in conscious dogs with healed myocardial infarction

1991 ◽  
Vol 261 (1) ◽  
pp. H63-H69 ◽  
Author(s):  
G. M. De Ferrari ◽  
E. Vanoli ◽  
M. Stramba-Badiale ◽  
S. S. Hull ◽  
R. D. Foreman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Rate ◽  
Coronary Artery ◽  
Ventricular Fibrillation ◽  
Myocardial Ischemia ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Acute Myocardial Ischemia ◽  
Acute Ischemia ◽  
Control Test

The role of vagal tone and reflexes in the genesis of life-threatening arrhythmias was investigated in a clinically relevant animal model for sudden cardiac death. Forty-five dogs with a healed anterior myocardial infarction in which transient myocardial ischemia during exercise did not induce malignant arrhythmias were utilized for the study. They underwent a further exercise and ischemia test in which atropine (75 micrograms/kg) was injected before coronary artery occlusion. Novel occurrence of ventricular arrhythmia, or worsening of the type of arrhythmia present in the control test, occurred in 23 of 45 dogs (51%) and ventricular fibrillation occurred in 11 of 45 (24%, P = 0.001). Analysis of heart rate response to acute ischemia in the control test indicates that these 11 animals had powerful vagal reflexes during coronary artery occlusion, compared with the 34 survivors (-32 +/- 35 vs. +2 +/- 27 beats/min, P = 0.003). This study indicates that approximately 75% of animals resistant to ventricular fibrillation are characterized by weak sympathetic reflexes in response to acute myocardial ischemia. In the remaining 25% powerful vagal reflexes counteract concomitant reflex sympathetic hyperactivity, decrease heart rate, and are essential for survival.

scholarly journals Successful interdisciplinary treatment as a rare cause of acute myocardial ischemia by intermittent tumor-associated obstruction of the left main coronary artery– A case report

2021 ◽  
Author(s):  
Katharina Huenges ◽  
Franz Hartmann ◽  
Bernd Panholzer ◽  
Thomas Puehler
Keyword(s):  
Case Report ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Myocardial Ischemia ◽  
Left Main Coronary Artery ◽  
Left Ventricular ◽  
Papillary Fibroelastoma ◽  
Interdisciplinary Treatment ◽  
Bridge To Surgery ◽  
Left Main

Abstract Background A papillary fibroelastoma of the aortic valve has been reported as a rare cause of myocardial ischemia. An advanced combined interventional and surgical approach leading to sufficient therapy for the patient is presented in this case report. Case summary A 56-year old female patient presented in an emergency room of a hospital with an acute coronary syndrome. Over 1.5 years, recurrent stable angina had been known in the patient and significant coronary artery disease has already been ruled out in a previous coronary angiogram. The patient was immediately transferred to the catheter laboratory due to cardiogenic shock where a drug-eluting stent was implanted to, firstly, recanalize the left main coronary artery and, secondly, to protect the left main ostium from obstruction by an echocardiographic-proven mass. During subsequent deterioration of hemodynamics caused by decreasing left ventricular function and acute severe mitral insufficiency, firstly an intra-aortic balloon pump and secondly a VA-ECMO was established through the femoral vessels. The patient was transferred to our cardiac surgery unit and was successfully operated utilizing a valve-sparing technique by extracting the tumor mass from the left coronary cusp and extracting the stent carefully from the left main coronary artery. Histology revealed a papillary fibroelastoma (Figure 4). Conclusion A papillary fibroelastoma of the aortic valve with intermittent obstruction of the coronary arteries requires surgical therapy. Interventional recanalization and extracorporeal support might be useful strategies to ensure the patient’s safety as a bridge to surgery.

Paradox of acute myocardial ischemia and successful PTCA: A case report of subtle coronary embolus

1986 ◽  
Vol 112 (6) ◽  
pp. 1317-1319 ◽  
Author(s):  
Stephen Presant ◽  
Michel Vandormael ◽  
Morton J. Kern
Keyword(s):  
Case Report ◽  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia

scholarly journals Mobilization of an anomalous retro aortic coronary artery to prevent myocardial ischemia after aortic valve replacement

2021 ◽  
Author(s):  
José Máximo ◽  
Paulo Pinho ◽  
Jorge Casanova
Keyword(s):  
At Risk ◽  
Case Report ◽  
Coronary Artery ◽  
Aortic Valve ◽  
Myocardial Ischemia ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Coronary Arteries ◽  
Right Coronary Artery ◽  
Valvular Surgery

During valvular surgery, abnormal coronary distribution, especially if unidentified by preoperative exams, may put coronary arteries at risk of damage. In this case report, we describe the approach to an anomalous right coronary artery during aortic valve replacement.

Acute Myocardial Ischemia Following Bee Sting in an Adolescent Male: A Case Report

2020 ◽  
Vol 21 ◽  
Author(s):  
Sandeep Tripathi ◽  
Agnieszka Kulikowska ◽  
Priti M. Patel ◽  
Nabil E. Hassan
Keyword(s):  
Case Report ◽  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
Adolescent Male ◽  
Bee Sting
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