Introduction

Author(s):  
Kevin Vallier

Based on recent research, there is probably a negative feedback loop between falling social and political trust and rising political polarization, which this book calls the distrust-divergence hypothesis. The goal of the book, as outlined in the introduction, is to show how liberal institutions can interrupt the feedback loop through policies that increase trust, and that do so in the right way. They do so by recognizing and protecting a range of basic rights that give rise to trust-generating institutions and practices, such as freedom of association, markets, social welfare programs, and democratic governance. Liberal institutions can thereby increase trust, and reduce the destructive aspects of political polarization as a result.

2020 ◽  
pp. 277-280
Author(s):  
Kevin Vallier

The epilogue reviews the argument of the book and explores how to restore trust and contain polarization. We can interrupt the negative feedback loop between distrust and partisan divergence through policies firmly within the liberal democratic toolkit. Freedom of association, markets, the welfare state, democratic governance, and elections have all been shown to promote trust for the right reasons. The epilogue also argues against right-wing and left-wing populism on the grounds that departures from liberalism are likely to make matters worse; the trust-generating properties of liberal institutions may be lost in a transition to a more populist regime, be it left-wing or right-wing.


Author(s):  
Kevin Vallier

Americans today don’t trust each other and their institutions as much as they used to. The collapse of social and political trust arguably has fueled our increasingly ferocious ideological conflicts and hardened partisanship. But is the decline in trust inevitable? Are we caught in a downward spiral that must end in war-like politics, institutional decay, and possibly even civil war? This book argues that American political and economic institutions are capable of creating and maintaining trust, even through polarized times. Combining philosophical arguments and empirical data, the author shows that liberal democracy, markets, and social welfare programs all play a vital role in producing social and political trust. Even more, these institutions can promote trust justly, by recognizing and respecting our basic human rights.


2021 ◽  
Vol 22 (16) ◽  
pp. 8472
Author(s):  
Senem Aykul ◽  
Jordan Maust ◽  
Vijayalakshmi Thamilselvan ◽  
Monique Floer ◽  
Erik Martinez-Hackert

Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is directed by developmental cues that include members of the TGF-β family. Our goal here was to elucidate, using the 3T3-L1 adipogenesis model, how TGF-β family growth factors and inhibitors regulate adipocyte development. We show that ligands of the Activin and TGF-β families, several ligand traps, and the SMAD1/5/8 signaling inhibitor LDN-193189 profoundly suppressed 3T3-L1 adipogenesis. Strikingly, anti-adipogenic traps and ligands engaged the same mechanism of action involving the simultaneous activation of SMAD2/3 and inhibition of SMAD1/5/8 signaling. This effect was rescued by the SMAD2/3 signaling inhibitor SB-431542. By contrast, although LDN-193189 also suppressed SMAD1/5/8 signaling and adipogenesis, its effect could not be rescued by SB-431542. Collectively, these findings reveal the fundamental role of SMAD1/5/8 for 3T3-L1 adipogenesis, and potentially identify a negative feedback loop that links SMAD2/3 activation with SMAD1/5/8 inhibition in adipogenic precursors.


2016 ◽  
Vol 24 (3) ◽  
pp. 421-432 ◽  
Author(s):  
Yanbo Wang ◽  
Hongwei Liang ◽  
Geyu Zhou ◽  
Xiuting Hu ◽  
Zhengya Liu ◽  
...  

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