Epileptic Slow Wave Activity

Fifty Years of Magnetoencephalography ◽

10.1093/oso/9780190935689.003.0014 ◽

2020 ◽

pp. 198-208

Author(s):

Stefan Rampp ◽

Martin Kaltenhäuser

Keyword(s):

Epilepsy Surgery ◽

Focal Epilepsy ◽

Activity Analysis ◽

Wave Activity ◽

Slow Wave Activity ◽

Interictal Spikes ◽

Intracranial Surgery ◽

Potential Value ◽

Focus Localization ◽

Slow Activity

In recent years, novel markers for the epileptic network beyond interictal spikes and ictal seizure correlates have been described. Slow activity in theta, delta, and lower frequency ranges have been detected using invasive electroencephalography (EEG) and noninvasive magnetoencephalography (MEG)/EEG. While such activity also occurs that is associated, for example, with large lesions and after intracranial surgery, certain subtypes may be used to localize the epileptic network. This chapter provides an overview of MEG slow frequency markers in patients with focal epilepsy. It covers the application of slow activity–based focus localization in patients undergoing workup for epilepsy surgery and discusses the relation to conventional spike-based analysis as well as the potential value of slow activity analysis in patients with previous surgery and persisting or recurring seizures.

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Slow-wave activity arising from the same area as epileptiform activity in the EEG of paediatric patients with focal epilepsy

Clinical Neurophysiology ◽

10.1016/j.clinph.2004.07.032 ◽

2005 ◽

Vol 116 (1) ◽

pp. 9-17 ◽

Cited By ~ 12

Author(s):

Bart Vanrumste ◽

Richard D. Jones ◽

Philip J. Bones ◽

Grant J. Carroll

Keyword(s):

Slow Wave ◽

Focal Epilepsy ◽

Epileptiform Activity ◽

Wave Activity ◽

Slow Wave Activity ◽

Paediatric Patients

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Relationship of sleep homeostasis to seizures and cognition in children with focal epilepsy

10.1101/2020.11.05.20226514 ◽

2020 ◽

Author(s):

Maria H Eriksson ◽

Torsten Baldeweg ◽

Ronit Pressler ◽

Stewart G Boyd ◽

Reto Huber ◽

...

Keyword(s):

Slow Wave ◽

Focal Epilepsy ◽

Nrem Sleep ◽

Wave Activity ◽

Slow Wave Activity ◽

Iq Testing ◽

Sleep Homeostasis ◽

Interictal Discharges ◽

Relationship Of ◽

The Relationship

AbstractObjectiveSleep disruption and cognitive impairment are important co-morbidities in childhood epilepsy, yet a mechanistic link has not been substantiated. Slow wave activity during sleep and its homeostatic decrease across the night is associated with synaptic renormalisation, and shows maturational changes over the course of childhood. Here, we aimed to investigate the effect of epilepsy on sleep homeostasis in the developing brain.MethodsWe examined the relationship of sleep homeostasis as reflected in slow wave activity to seizures, cognition and behaviour, comparing 22 children (aged 6 to 16 years) with focal epilepsy to 21 age-matched healthy controls. Participants underwent overnight sleep EEG and IQ testing and performed memory consolidation tasks. Their parents completed standard behavioural questionnaires.ResultsChildren with epilepsy had lower slow wave activity at the start of non-rapid eye movement (NREM) sleep, though similar overnight decline and slow wave activity in the final hour of NREM sleep. Both groups displayed an antero-posterior shift in peak slow wave activity overnight, though individual patients showed persistent local increases at scalp locations matching those of focal interictal discharges. Patients who had seizures during their admission had lower early-night slow wave activity, the group without seizures showing similar activity to controls. We found a positive correlation between full scale IQ and early-night slow wave activity in patients but not controls.InterpretationReduced early night slow wave activity in children with focal epilepsies is correlated with lower cognitive ability and more seizures and may reflect a reduction in learning-related synaptic potentiation.

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Slow Activity in Focal Epilepsy During Sleep and Wakefulness

Clinical EEG and Neuroscience ◽

10.1177/1550059416652055 ◽

2016 ◽

Vol 48 (3) ◽

pp. 200-208 ◽

Cited By ~ 11

Author(s):

Giovanni Pellegrino ◽

Mario Tombini ◽

Giuseppe Curcio ◽

Chiara Campana ◽

Giovanni Di Pino ◽

...

Keyword(s):

Slow Wave ◽

Focal Epilepsy ◽

Wave Activity ◽

Slow Wave Activity ◽

Sleep Cycle ◽

Delta Band ◽

Power Spectral ◽

Delta Sleep ◽

Beta Frequency ◽

Sleep Cycles

Introduction. We aimed to test differences between healthy subjects and patients with respect to slow wave activity during wakefulness and sleep. Methods. Fifteen patients affected by nonlesional focal epilepsy originating within temporal areas and fourteen matched controls underwent a 24-hour EEG recording. We studied the EEG power spectral density during wakefulness and sleep in delta (1-4 Hz), theta (5-7 Hz), alpha (8-11 Hz), sigma (12-15 Hz), and beta (16-20 Hz) bands. Results. During sleep, patients with focal epilepsy showed higher power from delta to beta frequency bands compared with controls. The effect was widespread for alpha band and above, while localized over the affected hemisphere for delta (sleep cycle 1, P = .006; sleep cycle 2, P = .008; sleep cycle 3, P = .017). The analysis of interhemispheric differences showed that the only frequency band stronger over the affected regions was the delta band during the first 2 sleep cycles (sleep cycle 1, P = .014; sleep cycle 2, P = .002). During wakefulness, patients showed higher delta/theta activity over the affected regions compared with controls. Conclusions. Patients with focal epilepsy showed a pattern of power increases characterized by a selective slow wave activity enhancement over the epileptic regions during daytime and sleep. This phenomenon was stronger and asymmetric during the first sleep cycles.

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0285 CHARACTERIZATION OF SLEEP NEED DISSIPATION USING EEG BASED SLOW-WAVE ACTIVITY ANALYSIS IN TWO AGE GROUPS

SLEEP ◽

10.1093/sleepj/zsx050.284 ◽

2017 ◽

Vol 40 (suppl_1) ◽

pp. A105-A105

Author(s):

G Garcia-Molina ◽

K Baehr ◽

B Steele ◽

T Tsoneva ◽

S Pfundtner ◽

...

Keyword(s):

Slow Wave ◽

Age Groups ◽

Activity Analysis ◽

Wave Activity ◽

Slow Wave Activity ◽

Two Age Groups

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Sa1640 NONINVASIVE MEASUREMENT OF SMALL BOWEL SLOW WAVE ACTIVITY IN NEONATES - A PILOT STUDY

Gastroenterology ◽

10.1016/s0016-5085(20)31606-1 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-364

Author(s):

Suseela Somarajan ◽

Nicole D. Muszynski ◽

Aurelia s. Monk ◽

Joseph D. Olson ◽

Alexandra Russell ◽

...

Keyword(s):

Pilot Study ◽

Small Bowel ◽

Slow Wave ◽

Wave Activity ◽

Slow Wave Activity ◽

Noninvasive Measurement

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Slow Wave Activity Related to Working Memory Maintenance in the N-Back Task

Journal of Psychophysiology ◽

10.1027/0269-8803/a000164 ◽

2016 ◽

Vol 30 (4) ◽

pp. 141-154 ◽

Cited By ~ 7

Author(s):

Kira Bailey ◽

Gregory Mlynarczyk ◽

Robert West

Keyword(s):

Working Memory ◽

Slow Wave ◽

Time Course ◽

Relevant Information ◽

Wave Activity ◽

Slow Wave Activity ◽

Response Accuracy ◽

Functional Neuroanatomy ◽

Stimulus Interval ◽

Back Task

Abstract. Working memory supports our ability to maintain goal-relevant information that guides cognition in the face of distraction or competing tasks. The N-back task has been widely used in cognitive neuroscience to examine the functional neuroanatomy of working memory. Fewer studies have capitalized on the temporal resolution of event-related brain potentials (ERPs) to examine the time course of neural activity in the N-back task. The primary goal of the current study was to characterize slow wave activity observed in the response-to-stimulus interval in the N-back task that may be related to maintenance of information between trials in the task. In three experiments, we examined the effects of N-back load, interference, and response accuracy on the amplitude of the P3b following stimulus onset and slow wave activity elicited in the response-to-stimulus interval. Consistent with previous research, the amplitude of the P3b decreased as N-back load increased. Slow wave activity over the frontal and posterior regions of the scalp was sensitive to N-back load and was insensitive to interference or response accuracy. Together these findings lead to the suggestion that slow wave activity observed in the response-to-stimulus interval is related to the maintenance of information between trials in the 1-back task.

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