Strange Case of Dr Jekyll and Mr Hyde and Other Tales

Author(s):  
Robert Louis Stevenson

Instantly the spirit of hell awoke in me and raged…I was suddenly struck through the heart by a cold thrill of terror.’ Stevenson’s short novel, published in 1886, became an instant classic. It was a Gothic horror that originated in a feverish nightmare, whose hallucinatory setting in the murky back streets of London gripped a nation mesmerized by crime and violence. The respectable doctor’s mysterious relationship with his disreputable associate is finally revealed in one of the most original and thrilling endings in English literature. In addition to Jekyll and Hyde, this edition also includes a number of short stories and essays written by Stevenson in the 1880s, minor masterpieces of fiction and comment: ’The Body Snatcher’, ’Markheim’, and ’Olalla’ feature grave-robbing, a sinister double, and degeneracy, while ’A Chapter on Dreams’ and ’A Gossip on Romance’ discuss artistic creation and the ’romance’ form. Appendixes provide extracts from contemporary writings on personality disorder, which set Stevenson’s tale in its full historical context.

2019 ◽  
Vol 19 (11) ◽  
pp. 870-879 ◽  
Author(s):  
Theodora A. Manolis ◽  
Antonis A. Manolis ◽  
Antonis S. Manolis

Background: Cannabis use has increased over the past several years as some countries have legalized its use for the treatment of certain medical conditions and/or for recreational use. Thus, concerns have risen about potential adverse health effects. Increasing number of reports have associated cannabis use with serious cardiovascular (CV) complications. Furthermore, there appears to be a likeness in the harmful health effects, especially on the CV and respiratory systems, of cannabis smoking to those of tobacco smoking. Objective: To review the CV effects of cannabis use and compare them with those of tobacco use. Methods: Articles were reviewed that were published in English literature reporting on cannabis and cannabinoid pharmacology and their effects on the CV system and their consequences. Emphasis was also placed on articles reporting on cannabis use in adolescents, exposure to secondhand smoke, its effect on exercise and finally its inter-relationship and similarities with tobacco use. Results: With growing cannabis use, an increasing number of reports have emerged associating marijuana use with serious and life-threatening CV complications, including acute coronary syndromes, potentially lethal cardiac arrhythmias and ischemic strokes. There are certain similarities of the deleterious CV and respiratory effects of cannabis smoking with those of tobacco smoking. Despite the difference in the active ingredients (tetrahydrocannabinol vs. nicotine), each substance produces a plethora of chemicals when smoked and these are largely identical; furthermore, due to different modes of smoking, cannabis chemicals are retained in the body for a longer time. Of course, concomitant tobacco and cannabis smoking is a perplexing factor in isolating damages specifically pertaining to cannabis use, while the health risk is additive. Although the mechanisms producing CV harm may be somewhat different between these two substances, the outcome appears similar, or even worse, as the effects may emerge at a younger age. Conclusion: There is an increasing concern that, apart from the mental health problem with cannabis smoking, societies may be facing another wave of a déjà vu/déjà vécu phenomenon similar to the tobacco smoking story.


2021 ◽  
Vol 7 ◽  
pp. 205951312098032
Author(s):  
Chenyu Huang ◽  
Rei Ogawa

Introduction: Keloids are pathological scars that are notorious for their chronic and relentless invasion into adjacent healthy skin, with commonly seen post-therapeutic recurrence after monotherapies. Methods: An English literature review on keloid pathophysiology was performed by searching the PubMed, Embase and Web of Science databases, to find out the up-to-date relevant articles. The level of evidence was evaluated based on the included studies with the highest level of evidence first. Results: Keloid morphology, signs, symptoms and the histopathological changes that occur in the local cells and extracellular matrix components are described. The theories on the pathophysiology of keloidogenesis that have been proposed to date are also covered; these include endocrinological, nutritional, vascular, and autoimmunological factors. In addition, we describe the local mechanical forces (and the mechanosignalling pathways by which these forces shape keloid cell activities) that promote keloid formation and determine the direction of invasion of keloids and the body sites that are prone to them. Conclusion: A better understanding of this pathological entity, particularly its mechanobiology, will aid the development of new diagnostic and therapeutic strategies for use in the clinic to prevent, reduce or even reverse the growth of this pathological scar. Lay Summary Keloids are skin scars that are famous for their chronic invasion into healthy skin, with commonly seen recurrence after surgeries. Cells such as lymphocytes, macrophages, mast cells and endothelial cells are involved in keloid growth. Particularly, endocrinological, nutritional, vascular, autoimmunological and mechanical factors actively take part in keloid progression.


2010 ◽  
Vol 39 (1) ◽  
pp. 143-166 ◽  
Author(s):  
Daniel Brown

The title of George Egerton'sfirst collection of short stories,Keynotes(1893), announces a concern with the beginnings of sequences, the first principles from which larger patterns are orchestrated. The stories introduce premises from which new social and sexual relations may be engendered and individual existential choices made, a philosophical intent that harks back to the preoccupation in classical Greek thought with the nature of the Good Life and how to live it, which Friedrich Nietzsche renews for modern Western philosophy. Egerton's broad but nonetheless radical engagement with Nietzschean thought can be traced through the references she makes to the philosopher inKeynotes, which are widely credited with being the first in English literature. Indeed, such allusions are, as Iveta Jusová observes, “the most frequent literary reference[s] in Egerton's texts” (53). They were also recognised and mobilised against her by some of her earliest critics.


1998 ◽  
Vol 112 (3) ◽  
pp. 278-279 ◽  
Author(s):  
I. J. M. Johnson ◽  
M. H. Tadpatrikar ◽  
J. F. Sharp

AbstractChondroma, a benign tumour which is common at many sites in the body, has not been reported in the English literature in the bony external auditory canal. The first such case at this anatomical site is described and the pathogenesis is considered.


Author(s):  
Victoria Margree ◽  
Daniel Orrells ◽  
Minna Vuohelainen

The introduction to the volume sets Richard Marsh in his historical context and argues that our understanding of late-Victorian and Edwardian professional authorship remains incomplete without a consideration of Marsh’s oeuvre. The introduction discusses Marsh as an exemplary professional writer producing topical popular fiction for an expanding middlebrow market. The seeming ephemerality of his literary production meant that its value was not appreciated by twentieth-century critics who were constructing the English literary canon. Marsh’s writing, however, deserves to be reread, as its negotiation of mainstream and counter-hegemonic discourses challenges our assumptions about fin-de-siècle literary culture. His novels and short stories engaged with and contributed to contemporary debates about aesthetic and economic value and interrogated the politics of gender, sexuality, empire and criminality.


Author(s):  
Ana Carolina Cadar

This chapter aimed to explore, through the framework of Freudian and Lacanian psychoanalytical theories, Vaslav Nijinsky's particular usage of his artistic creations. The history of Nijinsky's revolutionary talent and his mental health decline was the focus of this chapter. Nijinsky's formation as a dancer and his unique talent, and the specificities of his original subversive pieces were addressed. What can Nijinsky's trajectory teach about the artistry of sublimation and the use of the body in dance? Findings were contrasted with data from Maricela Sulbaran Zerpa's research concerning dancers and their relationship with their bodies alongside some contemporary testimonies of dancers.


Author(s):  
David W. Kling

The concluding chapter provides summary observations of the book’s themes that highlight the complex, multifaceted dimension of conversion throughout twenty centuries of Christian history. These include the convert’s cognizance of divine presence; the crucial importance of historical context (political, religious, institutional, and socioeconomic factors); continuity and discontinuity (how much of the new displaces the old in conversion?); nominal, incomplete, and “true” conversions; personal testimonies and narratives (the autobiographical impulse attests to the converted life); the role of gender; identity and the self; agency (are converts actors or are they being acted upon?); the mechanisms behind and the motivations for conversion; the body as a site of conversion; the role of music; conversion as event and process; coercive practices; and forms of communication in the converting process.


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tian Yang ◽  
Xudan Yang ◽  
Luping Wang ◽  
Jun Mo

Abstract Background Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature. Case presentation We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved. Conclusions As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea.


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