Molecular Characterization of the Mouse mtprd Gene, a Homologue of Human TPRD: Unique Gene Expression Suggesting Its Critical Role in the Pathophysiology of Down Syndrome

1998 ◽  
Vol 123 (6) ◽  
pp. 1055-1063 ◽  
Author(s):  
F. Tsukahara ◽  
I. Urakawa ◽  
M. Hattori ◽  
M. Hirai ◽  
K.-i. Ohba ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Molecular Characterization ◽  
Critical Role ◽  
Unique Gene

Molecular characterization of lincRNAs in Down syndrome associated leukemia

2012 ◽  
Vol 224 (03) ◽  
Author(s):  
A Streltsov ◽  
S Emmrich ◽  
F Engeland ◽  
JH Klusmann
Keyword(s):  
Down Syndrome ◽  
Molecular Characterization

scholarly journals Gene Expression Profiling and Molecular Characterization of Antimony Resistance in Leishmania amazonensis

2011 ◽  
Vol 5 (5) ◽  
pp. e1167 ◽  
Author(s):  
Rubens L. do Monte-Neto ◽  
Adriano C. Coelho ◽  
Frédéric Raymond ◽  
Danielle Légaré ◽  
Jacques Corbeil ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Molecular Characterization ◽  
Expression Profiling ◽  
Leishmania Amazonensis ◽  
Antimony Resistance

Molecular Characterization of Mn-superoxide Dismutase and Gene Expression Studies in Dietary Restricted Brachionus plicatilis Rotifers

Hydrobiologia ◽  
2005 ◽  
Vol 546 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Gen Kaneko ◽  
Tatsuki Yoshinaga ◽  
Yoshiko Yanagawa ◽  
Shigeharu Kinoshita ◽  
Katsumi Tsukamoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Superoxide Dismutase ◽  
Molecular Characterization ◽  
Brachionus Plicatilis ◽  
Expression Studies ◽  
Gene Expression Studies

scholarly journals Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

2011 ◽  
Vol 22 (11-12) ◽  
pp. 685-691 ◽  
Author(s):  
Laura G. Reinholdt ◽  
Yueming Ding ◽  
Griffith T. Gilbert ◽  
Anne Czechanski ◽  
Jeffrey P. Solzak ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Molecular Characterization ◽  
Translocation Breakpoints

scholarly journals Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Blood ◽  
2015 ◽  
Vol 125 (22) ◽  
pp. 3388-3392 ◽  
Author(s):  
Olli Silvennoinen ◽  
Stevan R. Hubbard
Keyword(s):  
Molecular Characterization ◽  
Human Disease ◽  
Molecular Mechanisms ◽  
Myeloproliferative Neoplasms ◽  
Critical Role ◽  
Hematologic Malignancies ◽  
Janus Kinase ◽  
Constitutive Activation

Abstract The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revolutionized the diagnostics of MPNs and led to development of novel JAK2 therapeutics. However, the molecular mechanisms by which mutations in the pseudokinase domain lead to hyperactivation of JAK2 and clinical disease have been unclear. Here, we describe recent advances in the molecular characterization of the JAK2 pseudokinase domain and how pathogenic mutations lead to constitutive activation of JAK2.

scholarly journals Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression

2006 ◽  
Vol 119 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Angel Chao ◽  
Tzu-Hao Wang ◽  
Yun-Shien Lee ◽  
Swei Hsueh ◽  
An-Shine Chao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Molecular Characterization ◽  
Microarray Analysis ◽  
Uterine Cervix ◽  
Squamous Carcinoma
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