A Prospective Study to Evaluate the Dose of Vitamin D Required to Correct Low 25-Hydroxyvitamin D Levels, Calcium, and Alkaline Phosphatase in Patients at Risk of Developing Antiepileptic Drug-Induced Osteomalacia

Background: Deficiency of 25 hydroxyvitamin D has been linked with predisposition to autoimmune disorders. Also, vitamin D has been found to be a causal factor in many autoimmune diseases. Objective of the study was to investigate vitamin D status in children with autoimmune thyroiditis attending endocrinology OPD at a tertiary centre in southern India.Methods: It is a case control study done in which 75 children (70 female, 5 male) with age and sex matched healthy controls were chosen. Free thyroxine, TSH, anti TPOAb, anti TGAb, 25 hydroxyvitamin D, serum calcium, phosphorus, alkaline phosphatase levels were estimated in both cases and control subjects. Children with anti TPO or anti TG positivity were divided into four groups based on their level of antibody titers.Results: The mean age in cases was 9.8±0.34 years. 25(OH)D levels were significantly lower in cases (15.07±1.14 ng/ml) compared to controls (17.82±1.13 ng/ml) (p<0.0006). Mean serum calcium levels in cases (9.35±0.16 mg/dl) were significantly lower when compared to controls (9.73±0.14 mg/dl) (p<0.0005). Similarly mean serum alkaline phosphatase level in cases (184.97±11.10 IU/L) were significantly elevated when compared with controls (122.37±6.82 IU/L) (p<0.0001). However, there was no significant difference in serum phosphorus levels between cases (4.42±0.10 mg/dl) and controls (4.43±0.14 mg/dl) (p=0.83). There was no significant difference in vitamin D level among the groups in both anti TPO (p< 0.283) and anti TG (p<0.148).Conclusions: The significant decrease in vitamin D levels in cases signifies that 25(OH)D may be an independent causal factor related to the autoimmunity in thyroid diseases.

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A Random Urine Test Can Identify Patients at Risk of Mesalamine Non-Adherence: A Prospective Study

The American Journal of Gastroenterology ◽

10.1038/ajg.2012.419 ◽

2013 ◽

Vol 108 (2) ◽

pp. 249-255 ◽

Cited By ~ 16

Author(s):

Anne E Gifford ◽

Anders H Berg ◽

Conor Lahiff ◽

Adam S Cheifetz ◽

Gary Horowitz ◽

...

Keyword(s):

At Risk ◽

Prospective Study ◽

Urine Test ◽

Patients At Risk ◽

A Prospective Study

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A Prospective Study of Inflammation Markers in Patients at Risk of Indirect Acute Lung Injury

Shock ◽

10.1097/00024382-200204000-00002 ◽

2002 ◽

Vol 17 (4) ◽

pp. 252-257 ◽

Cited By ~ 57

Author(s):

Annika Takala ◽

Irma Jousela ◽

Olli Takkunen ◽

Hannu Kautiainen ◽

Sten-Erik Jansson ◽

...

Keyword(s):

At Risk ◽

Acute Lung Injury ◽

Lung Injury ◽

Prospective Study ◽

Inflammation Markers ◽

Patients At Risk ◽

A Prospective Study

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Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects

Journal of Lipids ◽

10.1155/2013/623420 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 20

Author(s):

Jaydip Ray Chaudhuri ◽

K. Rukmini Mridula ◽

Alluri Anamika ◽

Demudu Babu Boddu ◽

Pradeep Kumar Misra ◽

...

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase ◽

Vitamin D Deficiency ◽

Serum Glucose ◽

C Reactive Protein ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

Calcium Phosphorus ◽

25 Hydroxyvitamin D ◽

Chemiluminescent Microparticle Immunoassay

Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia.Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects.Methodology. We recruited 150 asymptomatic consecutive subjects from patients’ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP).Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P=0.0001), mean serum glucose (P=0.0002) mean CRP (P=0.04), and mean alkaline phosphatase (P=0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5).Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.

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Vitamin D in Therapeutics: Past, Present and Future

MVP Journal of Medical Sciences ◽

10.18311/mvpjms/2016/v3/i2/6390 ◽

2016 ◽

Vol 3 (2) ◽

pp. 128

Author(s):

Jeetendra Singh ◽

Sameer B. Dharrao ◽

Tushar Baheti

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Human Body ◽

Indian Population ◽

Vitamin D Insufficiency ◽

Direct Sunlight ◽

Hydroxyvitamin D ◽

Patients At Risk ◽

25 Hydroxyvitamin D ◽

In The Beginning

In the beginning of 20th century vitamin D was classified as a vitamin but later considered as a prohormone ("conditional" vitamin) which influences the expression of more than 200 genes in the human body. Worldwide vitamin D insufficiency affects about 50% of the population and in India about 80% of population has vitamin D level less than normal. In India sunshine is abundant but still Indians are deprived of this sunshine vitamin. Minimal exposure to direct sunlight, staying indoors, use of sunscreen lotions, pollution, clothing, dietary and cooking habits are most important factors for vitamin D deficiency in the Indian population. Serum 25 hydroxyvitamin D level is the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D2 or vitamin D3 is recommended for patients having deficiency, keeping hypervitaminosis in mind.

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