Shear Wave Elastography in Assessment of Liver Fibrosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Alaa Kanaan Abdulateef ◽  
Sherif Abou Gamrah ◽  
Ayman Hassan Hassan ◽  
Samar Ramzy Ragheb
Keyword(s):  
Hepatitis C ◽  
Liver Fibrosis ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Radiology Department ◽  
P Value ◽  
Significant Fibrosis ◽  
Medicine Research ◽  
Medical Issues ◽  
Significant Liver Fibrosis

Abstract Background Liver fibrosis is major medical issues in patients with chronic hepatitis C (CHC). It may lead to cirrhosis, hepatocellular carcinoma (HCC) and liver-related death. Therefore, assessing the degree of fibrosis in patients with chronic liver diseases, especially before the advanced stage, is clinically important to allow early care and prevent fatal liver disease. Objective The plan was to do shear-wave Elastography after fibroscan (TE) in order to assess the stiffness of the liver, detect the changes occurred in hepatitis C patients and measure diagnostic accuracy of 2D- SWE by using TE as reference standard. Methods A cross-section study included 30 persons with positive hepatitis C. They were referred to Radiology department at National Hepatology and tropical medicine research institute. Results Our study included (30) patients who have hepatitis C positive, their ages ranged from (18) years old to (60) years old with mean SD of 52.97 ± 9.43. They were 17 females (56.7%) and 13 males (43.3%). Different liver fibrosis stages were observed by 2D-SWE as following: (FO) 4 patients (13.3%), (Fl) 4 patients (13.3%), (F2) 9 patients (30.0%), (F3) 10 patients (33.3%), (F4) 3 patients (10.0%). While TE (fibroscan) shows (FO) 6 (20.0%), (Fl) 3 patients (10.0%), (F2) 7 patients (23.3%), (F3) 8 patients (26.7%) (F4) 6 patients (20.0%). Our study showed that the relation between TE (fibroscan) and SWE finding had positive correlation of most patients with liver fibrosis with (p-value 0.006 and r-value 0.487). Because the impoltant of significant fibrosis for initiate antiviral protocol therapy, 30 patients classified into FO—FI (non-significant liver fibrosis) versus F2—F4 (significant liver fibrosis). Our study show significant discrimination was found between no/mild fibrosis (FO-FI) and significant fibrosis (F2-F4), shows the sensitivity of SWE in detection of significant fibrosis results is 95.2% and the specificity is 77.8%, PPV 90.91 %, NPV 87.5% and the accuracy 90.0% with cutoff value >5.7kPa. Conclusion SD-SWE is accurate in prediction significant fibrosis (2F2), Thus is expected to overcome the limitation of TE as a reliable method to assess fibrosis induce by hepatitis.

Accuracy of 2D shear wave elastography in the diagnosis of liver fibrosis in patients with chronic hepatitis C

2018 ◽  
Vol 46 (5) ◽  
pp. 319-327 ◽  
Author(s):  
Tamami Abe ◽  
Hidekatsu Kuroda ◽  
Yudai Fujiwara ◽  
Yuichi Yoshida ◽  
Akio Miyasaka ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Shear Wave ◽  
Chronic Hepatitis C ◽  
Shear Wave Elastography

scholarly journals Comparison of Two-Dimensional Shear Wave Elastography and Point Shear Wave Elastography for Assessing Liver Fibrosis

2019 ◽  
Author(s):  
Xiaozhuan Zhou ◽  
Jiawei Rao ◽  
Xukun Wu ◽  
Ronghai Deng ◽  
Yi Ma
Keyword(s):  
Liver Fibrosis ◽  
Shear Wave ◽  
Large Scale ◽  
Characteristic Curve ◽  
Shear Wave Elastography ◽  
Cochrane Library ◽  
Two Dimensional ◽  
Advanced Fibrosis ◽  
Likelihood Ratios ◽  
Significant Fibrosis

Abstract Background: Progressive liver fibrosis may result in cirrhosis, portal hypertension, and hepatocellular carcinoma (HCC). We performed a meta-analysis to compare liver fibrosis staging in chronic liver disease patients using two-dimensional shear wave elastography (2D-SWE) and point shear wave elastography (pSWE). Methods: PubMed, Web of Science, and Cochrane Library databases were searched until September 30th 2019 for studies evaluating the diagnostic performance of 2D-SWE and pSWE for assessing liver fibrosis. Pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios, and area under receiver operating characteristic curve (AUC) were estimated using the bivariate random effects model. Results: Eighteen studies with 3,082 patients were included in the analysis. The pooled sensitivities of 2D-SWE and pSWE were significantly different for the detection of significant fibrosis (0.83 vs. 0.70, P < 0.001) and advanced fibrosis (0.89 vs. 0.78, P < 0.05), but not for detection of cirrhosis (0.87 vs. 0.83, P > 0.05). The pooled specificities of 2D-SWE and pSWE were not significantly different for detection of significant fibrosis (0.83 vs. 0.83, P > 0.05), advanced fibrosis (0.80 vs. 0.85, P > 0.05), or cirrhosis (0.84 vs. 0.88, P > 0.05). Conclusions: Both 2D-SWE and pSWE have high sensitivity and specificity for detecting each stage of liver fibrosis. 2D-SWE has higher sensitivity than pSWE for detection of significant fibrosis and advanced fibrosis. Large-scale and multi-center studies are needed to directly compare 2D-SWE and pSWE.

scholarly journals Correlation of the Stiffness of Hepatocellular Carcinoma and Surrounding Liver Parenchyma by Point Shear Wave Elastography

2018 ◽  
Vol 35 (1) ◽  
pp. 10-15
Author(s):  
Bundit Chaopathomkul ◽  
Ornalin Boonsirisak ◽  
Krit Pongpirul
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Fibrosis ◽  
Shear Wave ◽  
Statistical Significance ◽  
Shear Wave Elastography ◽  
Liver Parenchyma ◽  
Significant Fibrosis ◽  
Significant Difference ◽  
Comparison Groups ◽  
Cirrhotic Group

The purpose of this study was to assess the correlation between hepatocellular carcinoma (HCC) and surrounding liver parenchyma stiffness using point shear wave elastography (pSWE). HCC was diagnosed using the criteria of the American Association for the Study of Liver Diseases. Liver fibrosis was classified into three groups (nonsignificant fibrosis, significant fibrosis, and cirrhosis). pSWE was performed on the HCC and the adjacent hepatic parenchyma and was expressed as kilopascal (kPa). A total of 59 HCC patients with 64 tumors were included in the study. The mean stiffnesses of HCC and liver background were 9.25 ± 3.76 and 10.84 ± 4.81 kPa, respectively. There was no statistical significance in HCC stiffness in any stage of liver fibrosis. Low HCC/liver background stiffness ratio was noted in the cirrhotic group and statistically significant in two comparison groups (cirrhosis vs significant fibrosis and cirrhosis vs nonsignificant fibrosis), with P < .001. In this cohort, HCC stiffness alone demonstrated no statistically significant difference in various stages of liver fibrosis.

scholarly journals One-Year Outcomes after Ledipasvir/Sofosbuvir Treatment of Chronic Hepatitis C in Teenagers with and without Significant Liver Fibrosis—A Case Series Report

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1518
Author(s):  
Maria Pokorska-Śpiewak ◽  
Anna Dobrzeniecka ◽  
Magdalena Marczyńska
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Liver Stiffness ◽  
Case Series ◽  
Significant Fibrosis ◽  
End Of Treatment ◽  
One Year ◽  
Significant Liver Fibrosis

One-year outcomes after therapy with ledipasvir/sofosbuvir (LDV/SOF) in children with chronic hepatitis C (CHC) presenting with and without significant liver fibrosis were analyzed. We included patients aged 12–17 years treated with LDV/SOF, presenting with significant fibrosis (F ≥ 2 on the METAVIR scale) in transient elastography (TE) at the baseline and we compared the outcomes with that of patients without fibrosis. Patients were followed every 4 weeks during the treatment, at the end of the therapy, at week 12 posttreatment, and one year after the end of treatment. Liver fibrosis was established using noninvasive methods: TE, aspartate transaminase-to-platelet ratio index (APRI), and Fibrosis-4 index (FIB-4). There were four patients with significant fibrosis at baseline: one with a fibrosis score of F2 on the METAVIR scale, and three with cirrhosis (F4) at baseline. One year after the end of treatment, the hepatitis C viral load was undetectable in three of them. One patient was lost to follow-up after week 4. In two out of the four patients, a significant improvement and regression of liver fibrosis was observed (from stage F4 and F2 to F0-F1 on the METAVIR scale). In one patient, the liver stiffness measurement median increased 12 weeks after the end of the treatment and then decreased, but still correlated with stage F4. An improvement in the APRI was observed in all patients. In four patients without fibrosis, the treatment was effective and no progression of fibrosis was observed. A one-year observation of teenagers with CHC and significant fibrosis treated with LDV/SOF revealed that regression of liver fibrosis is possible, but not certain. Further observations in larger groups of patients are necessary to find predictors of liver fibrosis regression.

scholarly journals Shear wave elastography (SWE) of the spleen in patients with hepatitis B and C but without significant liver fibrosis

2016 ◽  
Vol 89 (1066) ◽  
pp. 20160423 ◽  
Author(s):  
Aleksander Pawluś ◽  
Marcin Inglot ◽  
Mariusz Chabowski ◽  
Kinga Szymańska ◽  
Małgorzata Inglot ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatitis B ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Significant Liver Fibrosis
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