scholarly journals P009 Potential role of TOLLIP (Toll interacting protein) in IPF fibroblasts

QJM ◽  
2016 ◽  
Keyword(s):  
Potential Role ◽  
Interacting Protein

Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy

2008 ◽  
Vol 156 (1) ◽  
pp. 92-99.e2 ◽  
Author(s):  
Martin Landsberger ◽  
Alexander Staudt ◽  
Sangita Choudhury ◽  
Christiane Trimpert ◽  
Lars R. Herda ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Potential Role ◽  
Interacting Protein ◽  
Kv Channel

scholarly journals MiR-615 Agomir Encapsulated in Pluronic F-127 Alleviates Neuron Damage and Facilitates Function Recovery after Brachial Plexus Avulsion

2021 ◽  
Author(s):  
Kangzhen Chen ◽  
Lu Ding ◽  
Hua Shui ◽  
Yinru Liang ◽  
Xiaomin Zhang ◽  
...  
Keyword(s):  
Brachial Plexus ◽  
Upper Extremity ◽  
Potential Role ◽  
Functional Rehabilitation ◽  
Interacting Protein ◽  
Brachial Plexus Avulsion ◽  
Function Recovery ◽  
Study Results ◽  
Neuron Damage

Abstract Brachial plexus avulsion(BPA)is a devastating traumatic peripheral nerve injury complicated with paralysis of the upper extremity. We previously reported that leucine-rich repeat and immunoglobulin-like domain-containing NOGO receptor-interacting protein 1 (LINGO-1) has a potent role in inhibiting neuron survival and axonal regeneration after central nervous system (CNS) damage and miR-615 is a potential microRNA (miRNA) negatively regulated LINGO-1. However, the effect of miR-615 in BPA remains to be elucidated. Accumulating evidence indicates that pluronic F-127 (PF-127) hydrogel could serve as a promising vehicle for miRNA encapsulation. Thus, to further explore the potential role of hydrogel-miR-615 in BPA-reimplantation, the present study established the BPA rat model and injected miR-615 agomir encapsulated by PF-127 hydrogel into the reimplantation site using a microsyringe. In this study, results indicated that hydrogel-miR-615 agomir effectively alleviated motoneuron loss by LINGO-1 inhibition, promoted musculocutaneous nerve regeneration and myelination, reduced astrocytes activation, promoted angiogenesis and attenuated peripheral amyotrophy, leading to improved motor functional rehabilitation of the upper extremity. In conclusion, our findings demonstrate that miR-615-loaded PF-127 hydrogel may represent a novel therapeutic strategy for BPA treatment.

scholarly journals Localization of Thioredoxin-interacting Protein (TXNIP) mRNA in Epithelium of Human Gastrointestinal Tract

2003 ◽  
Vol 51 (7) ◽  
pp. 973-976 ◽  
Author(s):  
Yasuo Takahashi ◽  
Yukimoto Ishii ◽  
Akiko Murata ◽  
Toshihito Nagata ◽  
Satoshi Asai
Keyword(s):  
Mucosal Immunity ◽  
Potential Role ◽  
Negative Regulator ◽  
Gi Tract ◽  
Human Gastrointestinal Tract ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein ◽  
Differentiated Cells

Thioredoxin-interacting protein (TXNIP) is a negative regulator of thioredoxin. However, its role in the gastrointestinal (GI) epithelium is as yet unknown. Using in situ hybridization, we demonstrated that mRNA of TXNIP was differentially expressed in the epithelium of the human GI tract. TXNIP transcript was especially prominent in terminal differentiated cells. TXNIP was also highly expressed in lymphocytes in the lymphoid follicles. Our results suggest a new potential role of TXNIP in the differentiation of epithelial cells and in mucosal immunity of the GI tract.

scholarly journals Thyrotropin-Releasing Hormone-Stimulated Thyrotropin Expression Involves Islet-Brain-1/c-Jun N-Terminal Kinase Interacting Protein-1

Endocrinology ◽  
2004 ◽  
Vol 145 (12) ◽  
pp. 5623-5628 ◽  
Author(s):  
Hiroshi Abe ◽  
Koji Murao ◽  
Hitomi Imachi ◽  
Wen M. Cao ◽  
Xiao Yu ◽  
...  
Keyword(s):  
Potential Role ◽  
Endocrine Pancreas ◽  
Transient Transfection ◽  
Gh3 Cells ◽  
Gene Encoding ◽  
Interacting Protein ◽  
Protein Levels ◽  
Stimulation Of ◽  
Transfection Study

Abstract Islet-brain-1 (IB1)/c-Jun N-terminal kinase interacting protein 1 (JIP-1) is a scaffold protein that is expressed at high levels in neurons and the endocrine pancreas. IB1/JIP-1 interacts with the c-Jun N-terminal kinase and mediates the specific physiological stimuli (such as cytokines). However, the potential role of the protein in the pituitary has not been evaluated. Herein, we examined expression of the gene encoding IB1/JIP-1 and its translated product in the anterior pituitary gland and a pituitary cell line, GH3. We then examined the potential role of IB1/JIP-1 in controlling TSH-β gene expression. Exposure of GH3 cells to TRH stimulated the expression of IB1/JIP-1 protein levels, mRNA, and transcription of the promoter. The increase of IB1/JIP-1 content by transient transfection study of a vector encoding IB1/JIP-1 or by the stimulation of TRH stimulates TSH-β promoter activity. This effect is not found in the presence of a mutated nonfunctional (IB1S59N) IB1/JIP-1 protein. Together, these facts point to a central role of the IB1/JIP-1 protein in the control of TRH-mediated TSH-β stimulation.

Potential role of hematopoietic pre-B-cell leukemia transcription factor-interacting protein in oral carcinogenesis

2014 ◽  
Vol 44 (2) ◽  
pp. 115-125 ◽  
Author(s):  
Seiji Okada ◽  
Tarou Irié ◽  
Junichi Tanaka ◽  
Rika Yasuhara ◽  
Gou Yamamoto ◽  
...  
Keyword(s):  
Transcription Factor ◽  
B Cell ◽  
Potential Role ◽  
Cell Leukemia ◽  
Interacting Protein ◽  
Oral Carcinogenesis ◽  
B Cell Leukemia

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

Sign in / Sign up

Export Citation Format

Share Document