scholarly journals Inhibition of in-stent restenosis after graphene oxide double-layer drug coating with good biocompatibility

2019 ◽  
Vol 6 (5) ◽  
pp. 299-309 ◽  
Author(s):  
Shuang Ge ◽  
Yadong Xi ◽  
Ruolin Du ◽  
Yuzhen Ren ◽  
Zichen Xu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Double Layer ◽  
Toxicity Tests ◽  
Spray System ◽  
Stent Restenosis ◽  
Ultrasonic Spray ◽  
Before And After ◽  
Coated Surface ◽  
And Migration ◽  
In Stent Restenosis

Abstract In this study, we designed a double layer-coated vascular stent of 316L stainless steel using an ultrasonic spray system to achieve both antiproliferation and antithrombosis. The coating included an inner layer of graphene oxide (GO) loaded with docetaxel (DTX) and an outer layer of carboxymethyl chitosan (CMC) loaded with heparin (Hep). The coated surface was uniform without aggregation and shedding phenomena before and after stent expanded. The coating treatment was able to inhibit the adhesion and activation of platelets and the proliferation and migration of smooth muscle cells, indicating the excellent biocompatibility and antiproliferation ability. The toxicity tests showed that the GO/DTX and CMC/Hep coating did not cause deformity and organ abnormalities in zebrafish under stereomicroscope. The stents with GO double-layer coating were safe and could effectively prevent thrombosis and in-stent restenosis after the implantation into rabbit carotid arteries for 4–12 weeks.

P3577Predictors analysis of restenosis in calcified nodule with OCT-guided PCI

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Shibata ◽  
Y Kijima ◽  
R Nagoshi ◽  
A Kozuki ◽  
R Fujiwara ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Optical Coherence Tomography ◽  
Lumen Area ◽  
Younger Patients ◽  
Symmetry Index ◽  
Stent Restenosis ◽  
Before And After ◽  
Baseline Characteristics ◽  
In Stent Restenosis

Abstract Background Recent reports show that stenting for coronary calcified nodule (CN) resulted in frequent in-stent restenosis, however, its predictors are unclear. Method 117 consecutive calcified nodule lesions which underwent optical coherence tomography (OCT)-guided PCI were analyzed between January 2013 and March 2018. We investigated baseline characteristics and OCT parameter in CN site (Arc of CN, Lumen area and Symmetry index before and after PCI). Result CN site in-stent restenosis was seen 35 lesions (29.9%). Baseline characteristics was significantly different between restenosis group and non-restenosis group (Age; 68.9y.o vs. 73.3y.o, p=0.01, diabetes mellitus; 80.0% vs. 57.3%, Chronic Kidney Disease (CKD); 74.3% vs. 36.6%, Hemodialysis; 54.3% vs. 12.2%). Arc of CN before PCI in restenosis group was larger than that in non-restenosis group (122.7 vs. 110.0 degrees, p=0.01). Post stent symmetry index in restenosis group was smaller than that in non-restenosis group (0.64 vs. 0.75, p<0.01). Conclusion Younger patients, diabetes mellitus, CKD, hemodialysis, arc of CN before PCI, post stent symmetry index may be predictors of CN site restenosis.

Impact of Angioscopic Evaluation for Femoropopliteal In-Stent Restenosis Before and After Excimer Laser Atherectomy

2017 ◽  
Vol 51 (5) ◽  
pp. 335-337 ◽  
Author(s):  
Akiko Idemoto ◽  
Naotaka Okamoto ◽  
Akihiro Tanaka ◽  
Naoki Mori ◽  
Daisuke Nakamura ◽  
...  
Keyword(s):  
Excimer Laser ◽  
Direct Visualization ◽  
Total Occlusion ◽  
Stent Restenosis ◽  
Novel Treatment ◽  
Before And After ◽  
Excimer Laser Atherectomy ◽  
Laser Atherectomy ◽  
Lesion Morphology ◽  
In Stent Restenosis

In-stent restenosis (ISR) is a prevalent problem following stenting of femoropopliteal lesions. A potential novel treatment modality for ISR including excimer laser atherectomy (ELA) has become available. We performed ELA for in-stent chronic total occlusion (CTO) of femoropopliteal lesions and evaluated lesion morphology before and after ELA by angioscopy in 2 patients. The angioscopic findings clearly showed removal of in-stent thrombi after ELA. Thus, ELA may be effective for in-stent CTO of femoropopliteal lesions. This is the first report describing the direct visualization of ELA effect for vaporization of thrombi in femoropopliteal in-stent lesions by angioscopy.

scholarly journals Successful double-layer metal stents rotational ablation under 2-dimensional and 3-dimensional optical coherence tomography guidance: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tong Yaliang ◽  
Liu Guohui ◽  
Zhang Cheng ◽  
Du Beibei ◽  
Zhao Yanan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Percutaneous Coronary Intervention ◽  
Double Layer ◽  
Coronary Intervention ◽  
Metal Stents ◽  
Optical Coherence ◽  
3 Dimensional ◽  
Stent Restenosis ◽  
Percutaneous Coronary ◽  
In Stent Restenosis

Abstract Background Stent ablation with rotational atherectomy has been considered a bail-out strategy for the treatment of severe stent underexpansion. Only a few reports have yet shown rotational ablation for double-layer metal struts. Case presentation We present a case of 80-year-old female patient presented to our hospital because of worsening effort angina. Coronary angiography revealed severe in-stent restenosis in the proximal left anterior descending artery. Optical coherence tomography (OCT) examinations found that severe stenosis occurred at the overlap region with 2-layer underexpanded stents and circumferential calcification beneath them. Under the guidance of 2-dimensional (2D) and 3-dimensional (3D) OCT, we successfully performed percutaneous coronary intervention (PCI) of this lesion after adequate stent ablation, high-pressure balloon dilatation, and subsequent everolimus-eluting stent implantation. The patient recovered well uneventfully and discharged from hospital 7 days later. No restenosis occurred after 12 months. Conclusions We report a very rare case of in-stent restenosis due to double-layer underexpanded stents. The entire percutaneous coronary intervention procedure was performed step by step under the guidance of high-resolution OCT. Our findings highlight the specific value of 2D and 3D OCT guidance in double-layer stents rotational ablation.

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