Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease- modifying anti-rheumatic drugs

Rheumatology ◽  
1997 ◽  
Vol 36 (12) ◽  
pp. 1298-1303 ◽  
Author(s):  
R. Straub
Keyword(s):  
Clinical Outcome ◽  
Prognostic Marker ◽  
Interleukin 6 ◽  
Disease Modifying

scholarly journals Serum interleukin-6 as a prognostic marker in neonatal calf diarrhea

2016 ◽  
Vol 99 (8) ◽  
pp. 6563-6571 ◽  
Author(s):  
Stephani Fischer ◽  
Rolf Bauerfeind ◽  
Claus-Peter Czerny ◽  
Stephan Neumann
Keyword(s):  
Prognostic Marker ◽  
Interleukin 6 ◽  
Neonatal Calf ◽  
Calf Diarrhea ◽  
Neonatal Calf Diarrhea

CINSARC signature as a prognostic marker for clinical outcome in sarcomas and beyond

2018 ◽  
Vol 58 (2) ◽  
pp. 124-129 ◽  
Author(s):  
Frederic Chibon ◽  
Tom Lesluyes ◽  
Thibaud Valentin ◽  
Sophie Le Guellec
Keyword(s):  
Clinical Outcome ◽  
Prognostic Marker

scholarly journals TMIC-40. INTERLEUKIN-6 IN CEREBROSPINAL FLUID AS A PROGNOSTIC MARKER FOR GLIOBLASTOMA PATIENTS

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi265-vi265
Author(s):  
Takashi Sasayama ◽  
Kazuhiro Tanaka ◽  
Tatsuo Hori ◽  
Masamitsu Nishihara ◽  
Masahiro Maeyama ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Prognostic Marker ◽  
Interleukin 6

scholarly journals Serum Interleukin-10 But Not Interleukin-6 Is Related to Clinical Outcome in Patients With Resectable Hepatocellular Carcinoma

2000 ◽  
Vol 231 (4) ◽  
pp. 552-558 ◽  
Author(s):  
Gar-Yang Chau ◽  
Chew-Wun Wu ◽  
Wing-Yiu Lui ◽  
Tai-Jay Chang ◽  
Hua-Li Kao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Outcome ◽  
Interleukin 6 ◽  
Interleukin 10

Clinical significance of preoperative serum concentrations of interleukin-6 as a prognostic marker in patients with esophageal cancer

Esophagus ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 279-288 ◽  
Author(s):  
Yusuke Maeda ◽  
Hiroya Takeuchi ◽  
Satoru Matsuda ◽  
Akihiko Okamura ◽  
Kazumasa Fukuda ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Clinical Significance ◽  
Prognostic Marker ◽  
Interleukin 6 ◽  
Serum Concentrations ◽  
Preoperative Serum

scholarly journals Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe Sepsis

2008 ◽  
Vol 62 (4-5) ◽  
pp. 162-164 ◽  
Author(s):  
Oļegs Sabeļnikovs ◽  
Liene Ñikitina-Zaķe ◽  
Indulis Vanags
Keyword(s):  
Severe Sepsis ◽  
Plasma Level ◽  
Serum Level ◽  
Clinical Outcome ◽  
Interleukin 6 ◽  
Promoter Polymorphism ◽  
University Hospital ◽  
Genotype Distribution ◽  
Promoter Polymorphisms ◽  
Regulatory Polymorphism

Association of Interleukin 6 Promoter Polymorphism (-174G/C) with IL-6 Level and Outcome in Severe SepsisInterleukin (IL-6) is a key cytokine in the pathogenesis of severe sepsis. The importance of a regulatory polymorphism within the IL-6 promoter remains unclear in these patients. The aim of the study was to determine if IL-6 (-174 G/C) promoter polymorphism has an effect on IL-6 plasma level and outcome of severe sepsis. The study was conducted in general ICU of Stradiñš Clinical University Hospital. A total of 103 critically ill patients with confirmed severe sepsis were prospectively included. Association analysis of the IL-6 (-174C) allele with serum level and clinical outcome was performed. We found no differences in genotype distribution between survivors and nonsurvivors. The serum IL-6 level was significantly higher in nonsurvivors compared with survivors. We found an association of genotype with the IL-6 level in nonsurvivors, but not in survivors. Our findings show a functional significance of IL-6 promoter polymorphisms in nonsurviving severe sepsis patients.

scholarly journals Endotoxin and cytokines in patients with gastrointestinal tract perforation

1992 ◽  
Vol 1 (1) ◽  
pp. 45-48 ◽  
Author(s):  
S. Endo ◽  
K. Inada ◽  
Y. Inoue ◽  
T. Otsu ◽  
T. Kasai ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Clinical Outcome ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Endotoxin Level ◽  
Tumour Necrosis Factor Α ◽  
Inflammatory Lesions ◽  
Tract Perforation ◽  
Factor Α ◽  
Necrosis Factor

Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml-1. The clinical outcome correlated with the level of tumour necrosis factor α (TNFα), rather than with the endotoxin level. The high interleukin 6 (IL-6) level was shown in septic patients and no correlation was observed between the IL-6 level and the clinical outcome. Plasma TNFα levels tended to change independently from endotoxin levels, suggesting that TNFα may have been locally produced in inflammatory lesions.

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